PD64-06 COMPARISON OF PERFORMANCE OF PI-RADSV2 AND A QUANTITIATIVE PI-RADSV1 BASED PROTOCOL IN 3T MULTIPARAMETRIC MRI FOR DETECTION, GRADING AND STAGING OF PROSTATE CANCER USING WHOLE MOUNT HISTOPATHOLOGY AS REFERENCE STANDARD IN 569 PATIENTS. Article Swipe
Sohrab Afshari Mirak
,
Amirhossein Mohammadian Bajgiran
,
Melina Hosseiny
,
Sepideh Shakeri
,
Afshin Azadikhah
,
Anthony Sisk
,
Robert E. Reiter
,
Steven Raman
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1097/01.ju.0000557445.46140.1c
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1097/01.ju.0000557445.46140.1c
You have accessJournal of UrologyProstate Cancer: Detection & Screening VIII (PD64)1 Apr 2019PD64-06 COMPARISON OF PERFORMANCE OF PI-RADSV2 AND A QUANTITIATIVE PI-RADSV1 BASED PROTOCOL IN 3T MULTIPARAMETRIC MRI FOR DETECTION, GRADING AND STAGING OF PROSTATE CANCER USING WHOLE MOUNT HISTOPATHOLOGY AS REFERENCE STANDARD IN 569 PATIENTS. Sohrab Afshari Mirak*, Amirhossein Mohammadian Bajgiran, Melina Hosseiny, Sepideh Shakeri, Afshin Azadikhah, Anthony Sisk, Robert Reiter, and Steven Raman Sohrab Afshari Mirak*Sohrab Afshari Mirak* More articles by this author , Amirhossein Mohammadian BajgiranAmirhossein Mohammadian Bajgiran More articles by this author , Melina HosseinyMelina Hosseiny More articles by this author , Sepideh ShakeriSepideh Shakeri More articles by this author , Afshin AzadikhahAfshin Azadikhah More articles by this author , Anthony SiskAnthony Sisk More articles by this author , Robert ReiterRobert Reiter More articles by this author , and Steven RamanSteven Raman More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557445.46140.1cAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: To investigate the performance of PI-RADSv2 & a quantitative PI-RADSv1 based scoring system in 3T multiparametric-MRI (3TmpMRI) for prostate cancer (PCa) detection, grading & staging with whole-mount histopathology (WMHP) correlation. METHODS: This HIPAA-compliant, IRB-approved retrospective study, included 569 men with PCa, who underwent 3TmpMRI prior to prostatectomy, 12/2009-10/2017. The performance of a quantitative PI-RADSv1 based protocol (method 1) was compared to PIRADSv2 (method 2), evaluating sensitivity, PPV, grading & staging. In method 1, lesions were assigned an assessment grade based on the formula (T2WI+ 2*ADC + DCE − 0.25*transition zone (TZ))/4, where T2WI, ADC, & DCE were 1–5 assessment, & TZ was the binary assessment of TZ (1 if the lesion was in TZ and 0 if not). Method 2 was the standard protocol for PIRADSv2. For both methods, score 3 was considered as low suspicion & scores 4 & 5 were considered as high suspicion for PCa. All 3TmpMRI & histopathology lesions were included and evaluated using STATAv12. RESULTS: 1353 PCa lesions in 569 patients were included in the study. Methods 1 and 2 had similar sensitivity (44.3% vs 45%) and PPV (81.2% and 81.5%), respectively. The AUROC for PCa grading (Gleason score 6 vs >6) for methods 1 was slightly but non-significantly higher than method 2 (0.67 vs 0.64)(roccomp command, p = 0.25). However, both methods showed similar AUROC for PCa staging (
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- article
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- en
- Landing Page
- https://doi.org/10.1097/01.ju.0000557445.46140.1c
- https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000557445.46140.1c
- OA Status
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- Cited By
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- Related Works
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https://openalex.org/W2940503799Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/01.ju.0000557445.46140.1cDigital Object Identifier
- Title
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PD64-06 COMPARISON OF PERFORMANCE OF PI-RADSV2 AND A QUANTITIATIVE PI-RADSV1 BASED PROTOCOL IN 3T MULTIPARAMETRIC MRI FOR DETECTION, GRADING AND STAGING OF PROSTATE CANCER USING WHOLE MOUNT HISTOPATHOLOGY AS REFERENCE STANDARD IN 569 PATIENTS.Work title
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-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2019Year of publication
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2019-04-01Full publication date if available
- Authors
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Sohrab Afshari Mirak, Amirhossein Mohammadian Bajgiran, Melina Hosseiny, Sepideh Shakeri, Afshin Azadikhah, Anthony Sisk, Robert E. Reiter, Steven RamanList of authors in order
- Landing page
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https://doi.org/10.1097/01.ju.0000557445.46140.1cPublisher landing page
- PDF URL
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https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000557445.46140.1cDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000557445.46140.1cDirect OA link when available
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Medicine, Histopathology, Grading (engineering), Prostate cancer, Prostatectomy, Prostate, Nuclear medicine, Gynecology, Cancer, Pathology, Internal medicine, Civil engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 1, 2021: 1, 2020: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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