PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications Article Swipe
Rodolfo Debone Piazza
,
Wesley Renato Viali
,
Caio Carvalho dos Santos
,
Eloiza da Silva Nunes
,
Rodrigo Fernando Costa Marques
,
P.C. Morais
,
S.W. da Silva
,
J. A. H. Coaquira
,
Miguel Jafelicci
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1088/2053-1591/ab6700
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1088/2053-1591/ab6700
Superparamagnetic iron oxide nanoparticles (SPION) are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has emerged as a promisor therapeutic approach for cancer treatment and is based in controlled heating tumor tissue through the accumulation of SPIONs within cancer cells. This work describes a new route for the preparation of folate-conjugated PEGylated SPIONs, which involves the attachment of such molecules at the surface through polycondensation reactions, without the need for coupling agents or prior modification on the species involved. The size of iron oxide cores obtained by transmission electron microscopy was about 12 nm. The conjugation of folate onto SPIONs was confirmed by FTIR spectroscopy. The folate conjugated nanoparticles were colloidal stable in PBS, presenting a hydrodynamic diameter of 109 ± 1 nm and PDI 0.148. The obtained folate-targeted PEGylated SPIONs showed superparamagnetic behavior with a saturation magnetization of 73.1 emu·g −1 at 300 K. Their specific absorption rate (SAR) ranged from 32.8 to 15.0 W g −1 in an alternating magnetic field of 10–16 kA m −1 and frequency of 420–203 kHz. The heat generated was sufficient to raise the sample temperature to the therapeutic range used in MFH establishing this system as promising candidates for use in MFH treatment.
Related Topics
Concepts
Superparamagnetism
Surface modification
Materials science
Biocompatibility
Magnetic hyperthermia
Conjugated system
Nanotechnology
Fourier transform infrared spectroscopy
Transmission electron microscopy
Nanoparticle
Absorbance
Iron oxide nanoparticles
Magnetic nanoparticles
Chemical engineering
Magnetic field
Magnetization
Nuclear chemistry
Chemistry
Polymer
Chromatography
Composite material
Metallurgy
Engineering
Quantum mechanics
Physics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1088/2053-1591/ab6700
- https://iopscience.iop.org/article/10.1088/2053-1591/ab6700/pdf
- OA Status
- gold
- Cited By
- 36
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2997672033
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2997672033Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1088/2053-1591/ab6700Digital Object Identifier
- Title
-
PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applicationsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Rodolfo Debone Piazza, Wesley Renato Viali, Caio Carvalho dos Santos, Eloiza da Silva Nunes, Rodrigo Fernando Costa Marques, P.C. Morais, S.W. da Silva, J. A. H. Coaquira, Miguel JafelicciList of authors in order
- Landing page
-
https://doi.org/10.1088/2053-1591/ab6700Publisher landing page
- PDF URL
-
https://iopscience.iop.org/article/10.1088/2053-1591/ab6700/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://iopscience.iop.org/article/10.1088/2053-1591/ab6700/pdfDirect OA link when available
- Concepts
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Superparamagnetism, Surface modification, Materials science, Biocompatibility, Magnetic hyperthermia, Conjugated system, Nanotechnology, Fourier transform infrared spectroscopy, Transmission electron microscopy, Nanoparticle, Absorbance, Iron oxide nanoparticles, Magnetic nanoparticles, Chemical engineering, Magnetic field, Magnetization, Nuclear chemistry, Chemistry, Polymer, Chromatography, Composite material, Metallurgy, Engineering, Quantum mechanics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
36Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 7, 2023: 7, 2022: 4, 2021: 10Per-year citation counts (last 5 years)
- References (count)
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50Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5059318009 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I879563668 |
| citation_normalized_percentile.value | 0.86903397 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |