Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity Article Swipe
Jaquelyn T. Zoine
,
Kalyan Immadisetty
,
Jorge Ibañez-Vega
,
Sarah E. Moore
,
Chris Nevitt
,
Unmesha Thanekar
,
Liqing Tian
,
Abbas Karouni
,
Peter Chockley
,
Bright Arthur
,
Heather Sheppard
,
Jeffery M. Klco
,
Deanna Langfitt
,
Giedre Krenciute
,
Stephen Gottschalk
,
M. Madan Babu
,
Mireya Paulina Velasquez
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.xcrm.2024.101422
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.xcrm.2024.101422
The emergence of immune escape is a significant roadblock to developing effective chimeric antigen receptor (CAR) T cell therapies against hematological malignancies, including acute myeloid leukemia (AML). Here, we demonstrate feasibility of targeting two antigens simultaneously by combining a GRP78-specific peptide antigen recognition domain with a CD123-specific scFv to generate a peptide-scFv bispecific antigen recognition domain (78.123). To achieve this, we test linkers with varying length and flexibility and perform immunophenotypic and functional characterization. We demonstrate that bispecific CAR T cells successfully recognize and kill tumor cells that express GRP78, CD123, or both antigens and have improved antitumor activity compared to their monospecific counterparts when both antigens are expressed. Protein structure prediction suggests that linker length and compactness influence the functionality of the generated bispecific CARs. Thus, we present a bispecific CAR design strategy to prevent immune escape in AML that can be extended to other peptide-scFv combinations.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.xcrm.2024.101422
- http://www.cell.com/article/S2666379124000454/pdf
- OA Status
- gold
- Cited By
- 16
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391745166
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391745166Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.xcrm.2024.101422Digital Object Identifier
- Title
-
Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-01Full publication date if available
- Authors
-
Jaquelyn T. Zoine, Kalyan Immadisetty, Jorge Ibañez-Vega, Sarah E. Moore, Chris Nevitt, Unmesha Thanekar, Liqing Tian, Abbas Karouni, Peter Chockley, Bright Arthur, Heather Sheppard, Jeffery M. Klco, Deanna Langfitt, Giedre Krenciute, Stephen Gottschalk, M. Madan Babu, Mireya Paulina VelasquezList of authors in order
- Landing page
-
https://doi.org/10.1016/j.xcrm.2024.101422Publisher landing page
- PDF URL
-
https://www.cell.com/article/S2666379124000454/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.cell.com/article/S2666379124000454/pdfDirect OA link when available
- Concepts
-
Antigen, Chimeric antigen receptor, Peptide, Linker, Immune system, Myeloid leukemia, T cell, Immunology, Cancer research, Biology, Computational biology, Chemistry, Computer science, Biochemistry, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 5Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391745166 |
|---|---|
| doi | https://doi.org/10.1016/j.xcrm.2024.101422 |
| ids.doi | https://doi.org/10.1016/j.xcrm.2024.101422 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38350450 |
| ids.openalex | https://openalex.org/W4391745166 |
| fwci | 8.60394784 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D013601 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | T-Lymphocytes |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D053650 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000091342 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D000076962 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Receptors, Chimeric Antigen |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D015470 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D013601 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | T-Lymphocytes |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D053650 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000091342 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D000076962 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Receptors, Chimeric Antigen |
| mesh[11].qualifier_ui | Q000473 |
| mesh[11].descriptor_ui | D015470 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | pathology |
| mesh[11].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D013601 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | T-Lymphocytes |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D053650 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D000091342 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D000076962 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Receptors, Chimeric Antigen |
| mesh[17].qualifier_ui | Q000473 |
| mesh[17].descriptor_ui | D015470 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | pathology |
| mesh[17].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D006801 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Humans |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D013601 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | T-Lymphocytes |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D053650 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000091342 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D000076962 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Receptors, Chimeric Antigen |
| mesh[23].qualifier_ui | Q000473 |
| mesh[23].descriptor_ui | D015470 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | pathology |
| mesh[23].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D013601 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | T-Lymphocytes |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D053650 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D000091342 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D000076962 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Receptors, Chimeric Antigen |
| mesh[29].qualifier_ui | Q000473 |
| mesh[29].descriptor_ui | D015470 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | pathology |
| mesh[29].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D006801 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Humans |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D013601 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | T-Lymphocytes |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D053650 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D000091342 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D000076962 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Receptors, Chimeric Antigen |
| mesh[35].qualifier_ui | Q000473 |
| mesh[35].descriptor_ui | D015470 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | pathology |
| mesh[35].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D013601 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | T-Lymphocytes |
| mesh[38].qualifier_ui | Q000378 |
| mesh[38].descriptor_ui | D053650 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | metabolism |
| mesh[38].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D000091342 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D000076962 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Receptors, Chimeric Antigen |
| mesh[41].qualifier_ui | Q000473 |
| mesh[41].descriptor_ui | D015470 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | pathology |
| mesh[41].descriptor_name | Leukemia, Myeloid, Acute |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D006801 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Humans |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D013601 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | T-Lymphocytes |
| mesh[44].qualifier_ui | Q000378 |
| mesh[44].descriptor_ui | D053650 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | metabolism |
| mesh[44].descriptor_name | Interleukin-3 Receptor alpha Subunit |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D000091342 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Endoplasmic Reticulum Chaperone BiP |
| mesh[46].qualifier_ui | Q000378 |
| mesh[46].descriptor_ui | D000076962 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | metabolism |
| mesh[46].descriptor_name | Receptors, Chimeric Antigen |
| mesh[47].qualifier_ui | Q000473 |
| mesh[47].descriptor_ui | D015470 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | pathology |
| mesh[47].descriptor_name | Leukemia, Myeloid, Acute |
| type | article |
| title | Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity |
| biblio.issue | 2 |
| biblio.volume | 5 |
| biblio.last_page | 101422 |
| biblio.first_page | 101422 |
| grants[0].funder | https://openalex.org/F4320306242 |
| grants[0].award_id | |
| grants[0].funder_display_name | Assisi Foundation of Memphis |
| grants[1].funder | https://openalex.org/F4320313598 |
| grants[1].award_id | |
| grants[1].funder_display_name | American Lebanese Syrian Associated Charities |
| grants[2].funder | https://openalex.org/F4320332161 |
| grants[2].award_id | |
| grants[2].funder_display_name | National Institutes of Health |
| topics[0].id | https://openalex.org/T11491 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | CAR-T cell therapy research |
| topics[1].id | https://openalex.org/T11272 |
| topics[1].field.id | https://openalex.org/fields/22 |
| topics[1].field.display_name | Engineering |
| topics[1].score | 0.9939000010490417 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2204 |
| topics[1].subfield.display_name | Biomedical Engineering |
| topics[1].display_name | Nanowire Synthesis and Applications |
| topics[2].id | https://openalex.org/T10558 |
| topics[2].field.id | https://openalex.org/fields/22 |
| topics[2].field.display_name | Engineering |
| topics[2].score | 0.9842000007629395 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2208 |
| topics[2].subfield.display_name | Electrical and Electronic Engineering |
| topics[2].display_name | Advancements in Semiconductor Devices and Circuit Design |
| funders[0].id | https://openalex.org/F4320306242 |
| funders[0].ror | https://ror.org/03b8ttp75 |
| funders[0].display_name | Assisi Foundation of Memphis |
| funders[1].id | https://openalex.org/F4320313598 |
| funders[1].ror | |
| funders[1].display_name | American Lebanese Syrian Associated Charities |
| funders[2].id | https://openalex.org/F4320332161 |
| funders[2].ror | https://ror.org/01cwqze88 |
| funders[2].display_name | National Institutes of Health |
| is_xpac | False |
| apc_list.value | 5460 |
| apc_list.currency | USD |
| apc_list.value_usd | 5460 |
| apc_paid.value | 5460 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5460 |
| concepts[0].id | https://openalex.org/C147483822 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7589142322540283 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q103537 |
| concepts[0].display_name | Antigen |
| concepts[1].id | https://openalex.org/C3875195 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7444432377815247 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5099363 |
| concepts[1].display_name | Chimeric antigen receptor |
| concepts[2].id | https://openalex.org/C2779281246 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6562814712524414 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q172847 |
| concepts[2].display_name | Peptide |
| concepts[3].id | https://openalex.org/C2780557392 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5234089493751526 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q523796 |
| concepts[3].display_name | Linker |
| concepts[4].id | https://openalex.org/C8891405 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4892547130584717 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[4].display_name | Immune system |
| concepts[5].id | https://openalex.org/C2778729363 |
| concepts[5].level | 2 |
| concepts[5].score | 0.473898321390152 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11688946 |
| concepts[5].display_name | Myeloid leukemia |
| concepts[6].id | https://openalex.org/C2776090121 |
| concepts[6].level | 3 |
| concepts[6].score | 0.3885194659233093 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q193529 |
| concepts[6].display_name | T cell |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.38074591755867004 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C502942594 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3771743178367615 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[8].display_name | Cancer research |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.3746921718120575 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C70721500 |
| concepts[10].level | 1 |
| concepts[10].score | 0.36032769083976746 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[10].display_name | Computational biology |
| concepts[11].id | https://openalex.org/C185592680 |
| concepts[11].level | 0 |
| concepts[11].score | 0.32509273290634155 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[11].display_name | Chemistry |
| concepts[12].id | https://openalex.org/C41008148 |
| concepts[12].level | 0 |
| concepts[12].score | 0.19537827372550964 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[12].display_name | Computer science |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.10841798782348633 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| concepts[14].id | https://openalex.org/C111919701 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q9135 |
| concepts[14].display_name | Operating system |
| keywords[0].id | https://openalex.org/keywords/antigen |
| keywords[0].score | 0.7589142322540283 |
| keywords[0].display_name | Antigen |
| keywords[1].id | https://openalex.org/keywords/chimeric-antigen-receptor |
| keywords[1].score | 0.7444432377815247 |
| keywords[1].display_name | Chimeric antigen receptor |
| keywords[2].id | https://openalex.org/keywords/peptide |
| keywords[2].score | 0.6562814712524414 |
| keywords[2].display_name | Peptide |
| keywords[3].id | https://openalex.org/keywords/linker |
| keywords[3].score | 0.5234089493751526 |
| keywords[3].display_name | Linker |
| keywords[4].id | https://openalex.org/keywords/immune-system |
| keywords[4].score | 0.4892547130584717 |
| keywords[4].display_name | Immune system |
| keywords[5].id | https://openalex.org/keywords/myeloid-leukemia |
| keywords[5].score | 0.473898321390152 |
| keywords[5].display_name | Myeloid leukemia |
| keywords[6].id | https://openalex.org/keywords/t-cell |
| keywords[6].score | 0.3885194659233093 |
| keywords[6].display_name | T cell |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.38074591755867004 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/cancer-research |
| keywords[8].score | 0.3771743178367615 |
| keywords[8].display_name | Cancer research |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.3746921718120575 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/computational-biology |
| keywords[10].score | 0.36032769083976746 |
| keywords[10].display_name | Computational biology |
| keywords[11].id | https://openalex.org/keywords/chemistry |
| keywords[11].score | 0.32509273290634155 |
| keywords[11].display_name | Chemistry |
| keywords[12].id | https://openalex.org/keywords/computer-science |
| keywords[12].score | 0.19537827372550964 |
| keywords[12].display_name | Computer science |
| keywords[13].id | https://openalex.org/keywords/biochemistry |
| keywords[13].score | 0.10841798782348633 |
| keywords[13].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1016/j.xcrm.2024.101422 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210207453 |
| locations[0].source.issn | 2666-3791 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2666-3791 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cell Reports Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | |
| locations[0].pdf_url | http://www.cell.com/article/S2666379124000454/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cell Reports Medicine |
| locations[0].landing_page_url | https://doi.org/10.1016/j.xcrm.2024.101422 |
| locations[1].id | pmid:38350450 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cell reports. Medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38350450 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10897625 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by-nc-nd |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10897625/pdf/main.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cell Rep Med |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10897625 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5084233681 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7914-4610 |
| authorships[0].author.display_name | Jaquelyn T. Zoine |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[0].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[0].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jaquelyn T. Zoine |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[1].author.id | https://openalex.org/A5081146335 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-8261-6770 |
| authorships[1].author.display_name | Kalyan Immadisetty |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Structural Biology and Center of Excellence for Data Driven Discovery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I1313298211 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[1].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[1].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Kalyan Immadisetty |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA, Department of Structural Biology and Center of Excellence for Data Driven Discovery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[2].author.id | https://openalex.org/A5053861772 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4317-8573 |
| authorships[2].author.display_name | Jorge Ibañez-Vega |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[2].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Jorge Ibanez-Vega |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[3].author.id | https://openalex.org/A5008185042 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3925-8538 |
| authorships[3].author.display_name | Sarah E. Moore |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[3].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[3].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sarah E. Moore |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[4].author.id | https://openalex.org/A5060460178 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Chris Nevitt |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[4].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[4].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Chris Nevitt |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[5].author.id | https://openalex.org/A5084183136 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6118-825X |
| authorships[5].author.display_name | Unmesha Thanekar |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[5].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[5].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Unmesha Thanekar |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[6].author.id | https://openalex.org/A5086842371 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9921-0603 |
| authorships[6].author.display_name | Liqing Tian |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[6].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[6].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Liqing Tian |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[7].author.id | https://openalex.org/A5093911235 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Abbas Karouni |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[7].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[7].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Abbas Karouni |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[8].author.id | https://openalex.org/A5005929047 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-5181-2696 |
| authorships[8].author.display_name | Peter Chockley |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[8].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[8].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Peter J. Chockley |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[9].author.id | https://openalex.org/A5014651632 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-9040-461X |
| authorships[9].author.display_name | Bright Arthur |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[9].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[9].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Bright Arthur |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[10].author.id | https://openalex.org/A5021482854 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9623-2812 |
| authorships[10].author.display_name | Heather Sheppard |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[10].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[10].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Heather Sheppard |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[11].author.id | https://openalex.org/A5031896350 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-2961-6960 |
| authorships[11].author.display_name | Jeffery M. Klco |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[11].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[11].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Jeffery M. Klco |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[12].author.id | https://openalex.org/A5040095629 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-0941-5360 |
| authorships[12].author.display_name | Deanna Langfitt |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[12].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[12].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Deanna M. Langfitt |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[13].author.id | https://openalex.org/A5080946473 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-4335-0644 |
| authorships[13].author.display_name | Giedre Krenciute |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[13].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[13].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Giedre Krenciute |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[14].author.id | https://openalex.org/A5056105964 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-3991-7468 |
| authorships[14].author.display_name | Stephen Gottschalk |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[14].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[14].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Stephen Gottschalk |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[15].author.id | https://openalex.org/A5101784807 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-0556-6196 |
| authorships[15].author.display_name | M. Madan Babu |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Structural Biology and Center of Excellence for Data Driven Discovery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[15].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[15].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | M. Madan Babu |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Structural Biology and Center of Excellence for Data Driven Discovery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[16].author.id | https://openalex.org/A5024715014 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-1533-7234 |
| authorships[16].author.display_name | Mireya Paulina Velasquez |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[16].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[16].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[16].institutions[0].type | healthcare |
| authorships[16].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[16].author_position | last |
| authorships[16].raw_author_name | M. Paulina Velasquez |
| authorships[16].is_corresponding | True |
| authorships[16].raw_affiliation_strings | Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.cell.com/article/S2666379124000454/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11491 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | CAR-T cell therapy research |
| related_works | https://openalex.org/W2048490996, https://openalex.org/W2027377285, https://openalex.org/W4247375799, https://openalex.org/W2372005294, https://openalex.org/W2073620476, https://openalex.org/W2080971378, https://openalex.org/W3144105522, https://openalex.org/W2000091087, https://openalex.org/W1974255410, https://openalex.org/W2564332227 |
| cited_by_count | 16 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 11 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 5 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1016/j.xcrm.2024.101422 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210207453 |
| best_oa_location.source.issn | 2666-3791 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2666-3791 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cell Reports Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | |
| best_oa_location.pdf_url | http://www.cell.com/article/S2666379124000454/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cell Reports Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.xcrm.2024.101422 |
| primary_location.id | doi:10.1016/j.xcrm.2024.101422 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210207453 |
| primary_location.source.issn | 2666-3791 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2666-3791 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cell Reports Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | |
| primary_location.pdf_url | http://www.cell.com/article/S2666379124000454/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cell Reports Medicine |
| primary_location.landing_page_url | https://doi.org/10.1016/j.xcrm.2024.101422 |
| publication_date | 2024-02-01 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2899694188, https://openalex.org/W2897977935, https://openalex.org/W2892984448, https://openalex.org/W2093144236, https://openalex.org/W2811405063, https://openalex.org/W2998012982, https://openalex.org/W2730666287, https://openalex.org/W2908717823, https://openalex.org/W3038313191, https://openalex.org/W1993175465, https://openalex.org/W2124513722, https://openalex.org/W1537323319, https://openalex.org/W2013971016, https://openalex.org/W3151599062, https://openalex.org/W3039761202, https://openalex.org/W4225004652, https://openalex.org/W4224995733, https://openalex.org/W2913271650, https://openalex.org/W4210378967, https://openalex.org/W2289703314, https://openalex.org/W2605139437, https://openalex.org/W3007934784, https://openalex.org/W6606675058, https://openalex.org/W2761903029, https://openalex.org/W4310108239, https://openalex.org/W6810683314, https://openalex.org/W3014823961, https://openalex.org/W2322790172, https://openalex.org/W3022509419, https://openalex.org/W6768848800, https://openalex.org/W163085839, https://openalex.org/W3128868608, https://openalex.org/W3150736119, https://openalex.org/W3183475563, https://openalex.org/W3083676749, https://openalex.org/W2755677601, https://openalex.org/W2899700403, https://openalex.org/W3183792933, https://openalex.org/W3207961322, https://openalex.org/W3197491604, https://openalex.org/W2514418134, https://openalex.org/W4387378062, https://openalex.org/W2889691274, https://openalex.org/W2984295746, https://openalex.org/W4310102710, https://openalex.org/W2898640974, https://openalex.org/W3097512138, https://openalex.org/W2070387456, https://openalex.org/W2900789602, https://openalex.org/W2797054253, https://openalex.org/W2775756238, https://openalex.org/W2470876555, https://openalex.org/W1976187277, https://openalex.org/W4288445448, https://openalex.org/W2978325726, https://openalex.org/W4310104761, https://openalex.org/W4310112833, https://openalex.org/W1989566870, https://openalex.org/W3043123256, https://openalex.org/W3177828909, https://openalex.org/W4289527519, https://openalex.org/W2029667189, https://openalex.org/W2082053057, https://openalex.org/W2125028197, https://openalex.org/W2580377636, https://openalex.org/W3037938791, https://openalex.org/W2167279371, https://openalex.org/W4224324126, https://openalex.org/W31471983 |
| referenced_works_count | 69 |
| abstract_inverted_index.T | 16, 79 |
| abstract_inverted_index.a | 6, 38, 45, 50, 129 |
| abstract_inverted_index.To | 57 |
| abstract_inverted_index.We | 74 |
| abstract_inverted_index.be | 142 |
| abstract_inverted_index.by | 36 |
| abstract_inverted_index.in | 138 |
| abstract_inverted_index.is | 5 |
| abstract_inverted_index.of | 2, 31, 121 |
| abstract_inverted_index.or | 91 |
| abstract_inverted_index.to | 9, 48, 100, 134, 144 |
| abstract_inverted_index.we | 28, 60, 127 |
| abstract_inverted_index.AML | 139 |
| abstract_inverted_index.CAR | 78, 131 |
| abstract_inverted_index.The | 0 |
| abstract_inverted_index.and | 66, 68, 71, 83, 94, 116 |
| abstract_inverted_index.are | 107 |
| abstract_inverted_index.can | 141 |
| abstract_inverted_index.the | 119, 122 |
| abstract_inverted_index.two | 33 |
| abstract_inverted_index.both | 92, 105 |
| abstract_inverted_index.cell | 17 |
| abstract_inverted_index.have | 95 |
| abstract_inverted_index.kill | 84 |
| abstract_inverted_index.scFv | 47 |
| abstract_inverted_index.test | 61 |
| abstract_inverted_index.that | 76, 87, 113, 140 |
| abstract_inverted_index.when | 104 |
| abstract_inverted_index.with | 44, 63 |
| abstract_inverted_index.(CAR) | 15 |
| abstract_inverted_index.CARs. | 125 |
| abstract_inverted_index.Here, | 27 |
| abstract_inverted_index.Thus, | 126 |
| abstract_inverted_index.acute | 23 |
| abstract_inverted_index.cells | 80, 86 |
| abstract_inverted_index.other | 145 |
| abstract_inverted_index.their | 101 |
| abstract_inverted_index.this, | 59 |
| abstract_inverted_index.tumor | 85 |
| abstract_inverted_index.(AML). | 26 |
| abstract_inverted_index.CD123, | 90 |
| abstract_inverted_index.GRP78, | 89 |
| abstract_inverted_index.design | 132 |
| abstract_inverted_index.domain | 43, 55 |
| abstract_inverted_index.escape | 4, 137 |
| abstract_inverted_index.immune | 3, 136 |
| abstract_inverted_index.length | 65, 115 |
| abstract_inverted_index.linker | 114 |
| abstract_inverted_index.Protein | 109 |
| abstract_inverted_index.achieve | 58 |
| abstract_inverted_index.against | 19 |
| abstract_inverted_index.antigen | 13, 41, 53 |
| abstract_inverted_index.express | 88 |
| abstract_inverted_index.linkers | 62 |
| abstract_inverted_index.myeloid | 24 |
| abstract_inverted_index.peptide | 40 |
| abstract_inverted_index.perform | 69 |
| abstract_inverted_index.present | 128 |
| abstract_inverted_index.prevent | 135 |
| abstract_inverted_index.varying | 64 |
| abstract_inverted_index.activity | 98 |
| abstract_inverted_index.antigens | 34, 93, 106 |
| abstract_inverted_index.chimeric | 12 |
| abstract_inverted_index.compared | 99 |
| abstract_inverted_index.extended | 143 |
| abstract_inverted_index.generate | 49 |
| abstract_inverted_index.improved | 96 |
| abstract_inverted_index.leukemia | 25 |
| abstract_inverted_index.receptor | 14 |
| abstract_inverted_index.strategy | 133 |
| abstract_inverted_index.suggests | 112 |
| abstract_inverted_index.(78.123). | 56 |
| abstract_inverted_index.antitumor | 97 |
| abstract_inverted_index.combining | 37 |
| abstract_inverted_index.effective | 11 |
| abstract_inverted_index.emergence | 1 |
| abstract_inverted_index.generated | 123 |
| abstract_inverted_index.including | 22 |
| abstract_inverted_index.influence | 118 |
| abstract_inverted_index.recognize | 82 |
| abstract_inverted_index.roadblock | 8 |
| abstract_inverted_index.structure | 110 |
| abstract_inverted_index.targeting | 32 |
| abstract_inverted_index.therapies | 18 |
| abstract_inverted_index.bispecific | 52, 77, 124, 130 |
| abstract_inverted_index.developing | 10 |
| abstract_inverted_index.expressed. | 108 |
| abstract_inverted_index.functional | 72 |
| abstract_inverted_index.prediction | 111 |
| abstract_inverted_index.compactness | 117 |
| abstract_inverted_index.demonstrate | 29, 75 |
| abstract_inverted_index.feasibility | 30 |
| abstract_inverted_index.flexibility | 67 |
| abstract_inverted_index.recognition | 42, 54 |
| abstract_inverted_index.significant | 7 |
| abstract_inverted_index.counterparts | 103 |
| abstract_inverted_index.monospecific | 102 |
| abstract_inverted_index.peptide-scFv | 51, 146 |
| abstract_inverted_index.successfully | 81 |
| abstract_inverted_index.combinations. | 147 |
| abstract_inverted_index.functionality | 120 |
| abstract_inverted_index.hematological | 20 |
| abstract_inverted_index.malignancies, | 21 |
| abstract_inverted_index.CD123-specific | 46 |
| abstract_inverted_index.GRP78-specific | 39 |
| abstract_inverted_index.simultaneously | 35 |
| abstract_inverted_index.immunophenotypic | 70 |
| abstract_inverted_index.characterization. | 73 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5024715014 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 17 |
| corresponding_institution_ids | https://openalex.org/I1313298211 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.97258442 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |