Perceived Chronic Traumatic Encephalopathy and Suicidality in Former Professional Football Players Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.1001/jamaneurol.2024.3083
Importance Participation in American-style football (ASF) has been linked to chronic traumatic encephalopathy neuropathological change (CTE-NC), a specific neuropathologic finding that can only be established at autopsy. Despite being a postmortem diagnosis, living former ASF players may perceive themselves to have CTE-NC. At present, the proportion and clinical correlates of living former professional ASF athletes with perceived CTE who report suicidality are unknown. Objective To determine the proportion, clinical correlates, and suicidality of living former professional ASF players with perceived CTE. Design, Setting, and Participants A cross-sectional study within the Football Players Health Study at Harvard University was conducted from 2017 to 2020. Using electronic and paper surveys, this population-based study included former ASF players who contracted with a professional league from 1960 to 2020 and volunteered to fill out a baseline survey. Data for this study were analyzed from June 2023 through March 2024. Exposures Data included demographics, football-related exposures (eg, position, career duration), and current health problems (anxiety, attention-deficit/hyperactivity disorder, depression, diabetes, emotional and behavioral dyscontrol symptoms, headache, hyperlipidemia, hypertension, low testosterone level, pain, sleep apnea, and subjective cognitive function). Main Outcomes and Measures The proportion of participants reporting perceived CTE. Univariable and multivariable models were used to determine clinical and suicidality correlates of perceived CTE. Results Among 4180 former professional ASF players who volunteered to fill out a baseline survey, 1980 (47.4%) provided follow-up data (mean [SD] age, 57.7 [13.9] years). A total of 681 participants (34.4%) reported perceived CTE. Subjective cognitive difficulties, low testosterone level, headache, concussion signs and symptoms accrued during playing years, depressive/emotional and behavioral dyscontrol symptoms, pain, and younger age were significantly associated with perceived CTE. Suicidality was reported by 171 of 681 participants with perceived CTE (25.4%) and 64 of 1299 without perceived CTE (5.0%). After adjusting for established suicidality predictors (eg, depression), men with perceived CTE remained twice as likely to report suicidality (odds ratio, 2.06; 95% CI, 1.36-3.12; P < .001). Conclusions and Relevance This study found that approximately one-third of living former professional ASF players reported perceived CTE. Men with perceived CTE had an increased prevalence of suicidality and were more likely to have health problems associated with cognitive impairment compared with men without perceived CTE. Perceived CTE represents a novel risk factor for suicidality and, if present, should motivate the diagnostic assessment and treatment of medical and behavioral conditions that may be misattributed to CTE-NC.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1001/jamaneurol.2024.3083
- OA Status
- green
- Cited By
- 18
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402732686
Raw OpenAlex JSON
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https://openalex.org/W4402732686Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1001/jamaneurol.2024.3083Digital Object Identifier
- Title
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Perceived Chronic Traumatic Encephalopathy and Suicidality in Former Professional Football PlayersWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-23Full publication date if available
- Authors
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Rachel Grashow, Douglas P. Terry, Grant L. Iverson, Heather DiGregorio, Inana Dairi, Cheyenne Brown, Paula S. Atkeson, Alicia J. Whittington, Le'Roy E. Reese, Jonathan H. Kim, Niki A. Konstantinides, Herman A. Taylor, Frank E. Speizer, Daniel H. Daneshvar, Ross Zafonte, Marc G. Weisskopf, Aaron L. BaggishList of authors in order
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https://doi.org/10.1001/jamaneurol.2024.3083Publisher landing page
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://serval.unil.ch/notice/serval:BIB_71FE96737AA9Direct OA link when available
- Concepts
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Chronic traumatic encephalopathy, Football, Football players, Injury prevention, Poison control, Suicide prevention, Psychology, Human factors and ergonomics, Medical emergency, Occupational safety and health, Medicine, Psychiatry, Physical medicine and rehabilitation, Physical therapy, Concussion, History, Pathology, ArchaeologyTop concepts (fields/topics) attached by OpenAlex
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18Total citation count in OpenAlex
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2025: 15, 2024: 3Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_location.license | |
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| abstract_inverted_index.171 | 277 |
| abstract_inverted_index.681 | 237, 279 |
| abstract_inverted_index.95% | 315 |
| abstract_inverted_index.ASF | 34, 53, 76, 113, 213, 334 |
| abstract_inverted_index.CI, | 316 |
| abstract_inverted_index.CTE | 57, 283, 291, 304, 342, 368 |
| abstract_inverted_index.Men | 339 |
| abstract_inverted_index.The | 186 |
| abstract_inverted_index.age | 266 |
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| abstract_inverted_index.men | 301, 363 |
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| abstract_inverted_index.the | 44, 66, 89, 381 |
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| abstract_inverted_index.who | 58, 115, 215 |
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| abstract_inverted_index.2023 | 141 |
| abstract_inverted_index.4180 | 210 |
| abstract_inverted_index.57.7 | 231 |
| abstract_inverted_index.CTE. | 80, 192, 207, 242, 272, 338, 366 |
| abstract_inverted_index.Data | 133, 146 |
| abstract_inverted_index.June | 140 |
| abstract_inverted_index.Main | 182 |
| abstract_inverted_index.This | 324 |
| abstract_inverted_index.[SD] | 229 |
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| abstract_inverted_index.been | 7 |
| abstract_inverted_index.data | 227 |
| abstract_inverted_index.fill | 128, 218 |
| abstract_inverted_index.from | 99, 121, 139 |
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| abstract_inverted_index.more | 351 |
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| abstract_inverted_index.risk | 372 |
| abstract_inverted_index.that | 20, 327, 391 |
| abstract_inverted_index.this | 108, 135 |
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| abstract_inverted_index.were | 137, 197, 267, 350 |
| abstract_inverted_index.with | 55, 78, 117, 270, 281, 302, 340, 358, 362 |
| abstract_inverted_index.(ASF) | 5 |
| abstract_inverted_index.(mean | 228 |
| abstract_inverted_index.(odds | 312 |
| abstract_inverted_index.2.06; | 314 |
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| abstract_inverted_index.2024. | 144 |
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| abstract_inverted_index.novel | 371 |
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| abstract_inverted_index.sleep | 176 |
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| abstract_inverted_index..001). | 320 |
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| abstract_inverted_index.apnea, | 177 |
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| abstract_inverted_index.factor | 373 |
| abstract_inverted_index.former | 33, 51, 74, 112, 211, 332 |
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| abstract_inverted_index.league | 120 |
| abstract_inverted_index.level, | 174, 248 |
| abstract_inverted_index.likely | 308, 352 |
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| abstract_inverted_index.models | 196 |
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| abstract_inverted_index.(34.4%) | 239 |
| abstract_inverted_index.(47.4%) | 224 |
| abstract_inverted_index.(5.0%). | 292 |
| abstract_inverted_index.CTE-NC. | 41, 396 |
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| abstract_inverted_index.Harvard | 95 |
| abstract_inverted_index.Players | 91 |
| abstract_inverted_index.Results | 208 |
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| abstract_inverted_index.years). | 233 |
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| abstract_inverted_index.Football | 90 |
| abstract_inverted_index.Measures | 185 |
| abstract_inverted_index.Outcomes | 183 |
| abstract_inverted_index.Setting, | 82 |
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| abstract_inverted_index.athletes | 54 |
| abstract_inverted_index.autopsy. | 26 |
| abstract_inverted_index.baseline | 131, 221 |
| abstract_inverted_index.clinical | 47, 68, 201 |
| abstract_inverted_index.compared | 361 |
| abstract_inverted_index.football | 4 |
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| abstract_inverted_index.motivate | 380 |
| abstract_inverted_index.perceive | 37 |
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| abstract_inverted_index.surveys, | 107 |
| abstract_inverted_index.symptoms | 253 |
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| abstract_inverted_index.adjusting | 294 |
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| abstract_inverted_index.determine | 65, 200 |
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| abstract_inverted_index.emotional | 164 |
| abstract_inverted_index.exposures | 150 |
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| abstract_inverted_index.one-third | 329 |
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