Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming Article Swipe
Wanxian Luo
,
Chuanhui Xu
,
Linxi Li
,
Yunxiang Ji
,
Yezhong Wang
,
Yingjia Li
,
Yongyi Ye
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/nrr.nrr-d-23-01299
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/nrr.nrr-d-23-01299
JOURNAL/nrgr/04.03/01300535-202504000-00032/figure1/v/2025-03-16T133924Z/r/image-tiff Microglia, the primary immune cells within the brain, have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system, including Parkinson’s disease. Nanoscale perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity, but also exhibit remarkable anti-inflammatory properties. However, the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly understood. In this study, we developed perfluoropentane-based oxygen-loaded nanodroplets (PFP-OLNDs) and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo , and suppressed microglial activation in a mouse model of Parkinson’s disease. Microglial suppression led to a reduction in the inflammatory response, oxidative stress, and cell migration capacity in vitro . Consequently, the neurotoxic effects were mitigated, which alleviated neuronal degeneration. Additionally, ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic reprogramming. We further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α pathway. Collectively, our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/nrr.nrr-d-23-01299
- OA Status
- gold
- References
- 90
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400423223
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- OpenAlex ID
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https://openalex.org/W4400423223Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/nrr.nrr-d-23-01299Digital Object Identifier
- Title
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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogrammingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-03Full publication date if available
- Authors
-
Wanxian Luo, Chuanhui Xu, Linxi Li, Yunxiang Ji, Yezhong Wang, Yingjia Li, Yongyi YeList of authors in order
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https://doi.org/10.4103/nrr.nrr-d-23-01299Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.4103/nrr.nrr-d-23-01299Direct OA link when available
- Concepts
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Microglia, Reprogramming, PI3K/AKT/mTOR pathway, Cell biology, Inflammation, In vivo, Neuroprotection, Chemistry, Reactive oxygen species, Biology, Neuroscience, Biochemistry, Immunology, Signal transduction, Cell, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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