Performance of the decarboxylation index to predict CO2 removal and minute ventilation reduction under extracorporeal respiratory support
Article Swipe
Thomas Laumon
,
Elie Courvalin
,
Geoffrey Dagod
,
Pauline Deras
,
Mehdi Girard
,
Orianne Martinez
,
Camille Maury
,
Hugues Weber
,
Xavier Capdevila
,
Jonathan Charbit
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/aor.14471
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/aor.14471
Background The aim of this study was to assess the interdependence of extracorporeal blood flow (Qec) and gas flow (GF) in predicting CO 2 removal and reduction of minute mechanical ventilation under extracorporeal respiratory support. Methods All patients who benefited from V‐V ECMO and high‐flow ECCO 2 R in our intensive care unit over a period of 18 months were included. CO 2 removal was calculated from inlet/outlet blood port gases during the first 7 days of oxygenator use. The relationship between the Qec × GF product (named decarboxylation index and expressed in L 2 /min 2 ) and CO 2 removal or expired minute mechanical ventilation reduction ( EC MV ratio) was studied using linear regression models. Results Eighteen patients were analyzed, corresponding to 24 oxygenators and 261 datasets. CO 2 removal was 393 ml/min (IQR, 310–526) for 1.8 m 2 oxygenators and 179 ml/min (IQR, 165–235) for 1.3 m 2 oxygenators. The decarboxylation index was associated linearly with CO 2 removal ( R 2 = 0.62 and R 2 = 0.77 for the two oxygenators, respectively) and EC MV ratio ( R 2 = 0.72 and R 2 = 0.62, respectively). The 20L 2 /min 2 value (considering Qec = 2 L/min and GF = 10 L/min) was associated with an EC MV ratio between 61% and 29% for 1.8 m 2 oxygenators, and between 62% and 38% for 1.3 m 2 oxygenators. Conclusion The decarboxylation index is a simple parameter to predict CO 2 removal and EC MV ratio under extracorporeal respiratory support.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/aor.14471
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aor.14471
- OA Status
- hybrid
- Cited By
- 3
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4310225046
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4310225046Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/aor.14471Digital Object Identifier
- Title
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Performance of the decarboxylation index to predict
CO2 removal and minute ventilation reduction under extracorporeal respiratory supportWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-26Full publication date if available
- Authors
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Thomas Laumon, Elie Courvalin, Geoffrey Dagod, Pauline Deras, Mehdi Girard, Orianne Martinez, Camille Maury, Hugues Weber, Xavier Capdevila, Jonathan CharbitList of authors in order
- Landing page
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https://doi.org/10.1111/aor.14471Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aor.14471Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aor.14471Direct OA link when available
- Concepts
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Extracorporeal, Anesthesia, Extracorporeal circulation, Ventilation (architecture), Medicine, Chemistry, Surgery, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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