Performing Repeated Quantitative Small-Animal PET with an Arterial Input Function Is Routinely Feasible in Rats Article Swipe

PDF

Chi‐Cheng Huang , Chun‐Hu Wu , Ya-Yao Huang , Kai‐Yuan Tzen , Szu‐Fu Chen , Miao-Ling Tsai , Hsiao-Ming Wu ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.2967/jnumed.116.182402

Performing quantitative small-animal PET with an arterial input function has been considered technically challenging. Here, we introduce a catheterization procedure that keeps a rat physiologically stable for 1.5 mo. We demonstrated the feasibility of quantitative small-animal ¹⁸F-FDG PET in rats by performing it repeatedly to monitor the time course of variations in the cerebral metabolic rate of glucose (CMR_glc). Methods: Aseptic surgery was performed on 2 rats. Each rat underwent catheterization of the right femoral artery and left femoral vein. The catheters were sealed with microinjection ports and then implanted subcutaneously. Over the next 3 wk, each rat underwent ¹⁸F-FDG quantitative small-animal PET 6 times. The CMR_glc of each brain region was calculated using a 3-compartment model and an operational equation that included a k*₄Results: On 6 mornings, we completed 12 ¹⁸F-FDG quantitative small-animal PET studies on 2 rats. The rats grew steadily before and after the 6 quantitative small-animal PET studies. The CMR_glc of the conscious brain (e.g., right parietal region, 99.6 ± 10.2 μmol/100 g/min; n = 6) was comparable to that for ¹⁴C-deoxyglucose autoradiographic methods. Conclusion: Maintaining good blood patency in catheterized rats is not difficult. Longitudinal quantitative small-animal PET imaging with an arterial input function can be performed routinely.

Related Topics

Medicine

Femoral Artery

Nuclear Medicine

Quantitative Research

Positron Emission Tomography

Anesthesia

Internal Medicine

Concepts

Medicine Femoral artery Nuclear medicine Animal model Quantitative assessment Arterial blood Positron emission tomography Surgery Anesthesia Internal medicine Risk analysis (engineering)

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.2967/jnumed.116.182402
PDF: http://jnm.snmjournals.org/content/58/4/611.full.pdf
OA Status: bronze
Cited By: 7
References: 27
Related Works: 10
OpenAlex ID: https://openalex.org/W2539504554

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W2539504554

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.2967/jnumed.116.182402

Digital Object Identifier
Title: Performing Repeated Quantitative Small-Animal PET with an Arterial Input Function Is Routinely Feasible in Rats

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2016

Year of publication
Publication date: 2016-10-27

Full publication date if available
Authors: Chi‐Cheng Huang, Chun‐Hu Wu, Ya-Yao Huang, Kai‐Yuan Tzen, Szu‐Fu Chen, Miao-Ling Tsai, Hsiao-Ming Wu

List of authors in order
Landing page: https://doi.org/10.2967/jnumed.116.182402

Publisher landing page
PDF URL: https://jnm.snmjournals.org/content/58/4/611.full.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: bronze

Open access status per OpenAlex
OA URL: https://jnm.snmjournals.org/content/58/4/611.full.pdf

Direct OA link when available
Concepts: Medicine, Femoral artery, Nuclear medicine, Animal model, Quantitative assessment, Arterial blood, Positron emission tomography, Surgery, Anesthesia, Internal medicine, Risk analysis (engineering)

Top concepts (fields/topics) attached by OpenAlex
Cited by: 7

Total citation count in OpenAlex
Citations by year (recent): 2024: 1, 2021: 1, 2020: 2, 2019: 1, 2018: 2

Per-year citation counts (last 5 years)
References (count): 27

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W2539504554
doi	https://doi.org/10.2967/jnumed.116.182402
ids.doi	https://doi.org/10.2967/jnumed.116.182402
ids.mag	2539504554
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/27789717
ids.openalex	https://openalex.org/W2539504554
fwci	0.83558518
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000818
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Animals
mesh[1].qualifier_ui	Q000000981
mesh[1].descriptor_ui	D001158
mesh[1].is_major_topic	False
mesh[1].qualifier_name	diagnostic imaging
mesh[1].descriptor_name	Arteries
mesh[2].qualifier_ui	Q000502
mesh[2].descriptor_ui	D001158
mesh[2].is_major_topic	False
mesh[2].qualifier_name	physiology
mesh[2].descriptor_name	Arteries
mesh[3].qualifier_ui
mesh[3].descriptor_ui	D001692
mesh[3].is_major_topic	False
mesh[3].qualifier_name
mesh[3].descriptor_name	Biological Transport
mesh[4].qualifier_ui	Q000000981
mesh[4].descriptor_ui	D001921
mesh[4].is_major_topic	False
mesh[4].qualifier_name	diagnostic imaging
mesh[4].descriptor_name	Brain
mesh[5].qualifier_ui	Q000378
mesh[5].descriptor_ui	D001921
mesh[5].is_major_topic	False
mesh[5].qualifier_name	metabolism
mesh[5].descriptor_name	Brain
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D057785
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Catheters
mesh[7].qualifier_ui
mesh[7].descriptor_ui	D005240
mesh[7].is_major_topic	False
mesh[7].qualifier_name
mesh[7].descriptor_name	Feasibility Studies
mesh[8].qualifier_ui	Q000378
mesh[8].descriptor_ui	D019788
mesh[8].is_major_topic	True
mesh[8].qualifier_name	metabolism
mesh[8].descriptor_name	Fluorodeoxyglucose F18
mesh[9].qualifier_ui	Q000295
mesh[9].descriptor_ui	D049268
mesh[9].is_major_topic	False
mesh[9].qualifier_name	instrumentation
mesh[9].descriptor_name	Positron-Emission Tomography
mesh[10].qualifier_ui	Q000379
mesh[10].descriptor_ui	D049268
mesh[10].is_major_topic	False
mesh[10].qualifier_name	methods
mesh[10].descriptor_name	Positron-Emission Tomography
mesh[11].qualifier_ui
mesh[11].descriptor_ui	D051381
mesh[11].is_major_topic	False
mesh[11].qualifier_name
mesh[11].descriptor_name	Rats
mesh[12].qualifier_ui
mesh[12].descriptor_ui	D017207
mesh[12].is_major_topic	False
mesh[12].qualifier_name
mesh[12].descriptor_name	Rats, Sprague-Dawley
mesh[13].qualifier_ui
mesh[13].descriptor_ui	D015203
mesh[13].is_major_topic	False
mesh[13].qualifier_name
mesh[13].descriptor_name	Reproducibility of Results
mesh[14].qualifier_ui
mesh[14].descriptor_ui	D000818
mesh[14].is_major_topic	False
mesh[14].qualifier_name
mesh[14].descriptor_name	Animals
mesh[15].qualifier_ui	Q000000981
mesh[15].descriptor_ui	D001158
mesh[15].is_major_topic	False
mesh[15].qualifier_name	diagnostic imaging
mesh[15].descriptor_name	Arteries
mesh[16].qualifier_ui	Q000502
mesh[16].descriptor_ui	D001158
mesh[16].is_major_topic	False
mesh[16].qualifier_name	physiology
mesh[16].descriptor_name	Arteries
mesh[17].qualifier_ui
mesh[17].descriptor_ui	D001692
mesh[17].is_major_topic	False
mesh[17].qualifier_name
mesh[17].descriptor_name	Biological Transport
mesh[18].qualifier_ui	Q000000981
mesh[18].descriptor_ui	D001921
mesh[18].is_major_topic	False
mesh[18].qualifier_name	diagnostic imaging
mesh[18].descriptor_name	Brain
mesh[19].qualifier_ui	Q000378
mesh[19].descriptor_ui	D001921
mesh[19].is_major_topic	False
mesh[19].qualifier_name	metabolism
mesh[19].descriptor_name	Brain
mesh[20].qualifier_ui
mesh[20].descriptor_ui	D057785
mesh[20].is_major_topic	False
mesh[20].qualifier_name
mesh[20].descriptor_name	Catheters
mesh[21].qualifier_ui
mesh[21].descriptor_ui	D005240
mesh[21].is_major_topic	False
mesh[21].qualifier_name
mesh[21].descriptor_name	Feasibility Studies
mesh[22].qualifier_ui	Q000378
mesh[22].descriptor_ui	D019788
mesh[22].is_major_topic	True
mesh[22].qualifier_name	metabolism
mesh[22].descriptor_name	Fluorodeoxyglucose F18
mesh[23].qualifier_ui	Q000295
mesh[23].descriptor_ui	D049268
mesh[23].is_major_topic	False
mesh[23].qualifier_name	instrumentation
mesh[23].descriptor_name	Positron-Emission Tomography
mesh[24].qualifier_ui	Q000379
mesh[24].descriptor_ui	D049268
mesh[24].is_major_topic	False
mesh[24].qualifier_name	methods
mesh[24].descriptor_name	Positron-Emission Tomography
mesh[25].qualifier_ui
mesh[25].descriptor_ui	D051381
mesh[25].is_major_topic	False
mesh[25].qualifier_name
mesh[25].descriptor_name	Rats
mesh[26].qualifier_ui
mesh[26].descriptor_ui	D017207
mesh[26].is_major_topic	False
mesh[26].qualifier_name
mesh[26].descriptor_name	Rats, Sprague-Dawley
mesh[27].qualifier_ui
mesh[27].descriptor_ui	D015203
mesh[27].is_major_topic	False
mesh[27].qualifier_name
mesh[27].descriptor_name	Reproducibility of Results
type	article
title	Performing Repeated Quantitative Small-Animal PET with an Arterial Input Function Is Routinely Feasible in Rats
biblio.issue	4
biblio.volume	58
biblio.last_page	616
biblio.first_page	611
topics[0].id	https://openalex.org/T10522
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2741
topics[0].subfield.display_name	Radiology, Nuclear Medicine and Imaging
topics[0].display_name	Medical Imaging Techniques and Applications
topics[1].id	https://openalex.org/T10378
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9976999759674072
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2741
topics[1].subfield.display_name	Radiology, Nuclear Medicine and Imaging
topics[1].display_name	Advanced MRI Techniques and Applications
topics[2].id	https://openalex.org/T10129
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9969000220298767
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2716
topics[2].subfield.display_name	Genetics
topics[2].display_name	Glioma Diagnosis and Treatment
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C71924100
concepts[0].level	0
concepts[0].score	0.6835764646530151
concepts[0].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[0].display_name	Medicine
concepts[1].id	https://openalex.org/C2779723990
concepts[1].level	2
concepts[1].score	0.6151435971260071
concepts[1].wikidata	https://www.wikidata.org/wiki/Q707174
concepts[1].display_name	Femoral artery
concepts[2].id	https://openalex.org/C2989005
concepts[2].level	1
concepts[2].score	0.5731143355369568
concepts[2].wikidata	https://www.wikidata.org/wiki/Q214963
concepts[2].display_name	Nuclear medicine
concepts[3].id	https://openalex.org/C2778117688
concepts[3].level	2
concepts[3].score	0.5377021431922913
concepts[3].wikidata	https://www.wikidata.org/wiki/Q264024
concepts[3].display_name	Animal model
concepts[4].id	https://openalex.org/C2984588014
concepts[4].level	2
concepts[4].score	0.4353378713130951
concepts[4].wikidata	https://www.wikidata.org/wiki/Q730675
concepts[4].display_name	Quantitative assessment
concepts[5].id	https://openalex.org/C2779537118
concepts[5].level	2
concepts[5].score	0.41540759801864624
concepts[5].wikidata	https://www.wikidata.org/wiki/Q618362
concepts[5].display_name	Arterial blood
concepts[6].id	https://openalex.org/C2775842073
concepts[6].level	2
concepts[6].score	0.4125669002532959
concepts[6].wikidata	https://www.wikidata.org/wiki/Q208376
concepts[6].display_name	Positron emission tomography
concepts[7].id	https://openalex.org/C141071460
concepts[7].level	1
concepts[7].score	0.2991567850112915
concepts[7].wikidata	https://www.wikidata.org/wiki/Q40821
concepts[7].display_name	Surgery
concepts[8].id	https://openalex.org/C42219234
concepts[8].level	1
concepts[8].score	0.2526426911354065
concepts[8].wikidata	https://www.wikidata.org/wiki/Q131130
concepts[8].display_name	Anesthesia
concepts[9].id	https://openalex.org/C126322002
concepts[9].level	1
concepts[9].score	0.23628917336463928
concepts[9].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[9].display_name	Internal medicine
concepts[10].id	https://openalex.org/C112930515
concepts[10].level	1
concepts[10].score	0.0
concepts[10].wikidata	https://www.wikidata.org/wiki/Q4389547
concepts[10].display_name	Risk analysis (engineering)
keywords[0].id	https://openalex.org/keywords/medicine
keywords[0].score	0.6835764646530151
keywords[0].display_name	Medicine
keywords[1].id	https://openalex.org/keywords/femoral-artery
keywords[1].score	0.6151435971260071
keywords[1].display_name	Femoral artery
keywords[2].id	https://openalex.org/keywords/nuclear-medicine
keywords[2].score	0.5731143355369568
keywords[2].display_name	Nuclear medicine
keywords[3].id	https://openalex.org/keywords/animal-model
keywords[3].score	0.5377021431922913
keywords[3].display_name	Animal model
keywords[4].id	https://openalex.org/keywords/quantitative-assessment
keywords[4].score	0.4353378713130951
keywords[4].display_name	Quantitative assessment
keywords[5].id	https://openalex.org/keywords/arterial-blood
keywords[5].score	0.41540759801864624
keywords[5].display_name	Arterial blood
keywords[6].id	https://openalex.org/keywords/positron-emission-tomography
keywords[6].score	0.4125669002532959
keywords[6].display_name	Positron emission tomography
keywords[7].id	https://openalex.org/keywords/surgery
keywords[7].score	0.2991567850112915
keywords[7].display_name	Surgery
keywords[8].id	https://openalex.org/keywords/anesthesia
keywords[8].score	0.2526426911354065
keywords[8].display_name	Anesthesia
keywords[9].id	https://openalex.org/keywords/internal-medicine
keywords[9].score	0.23628917336463928
keywords[9].display_name	Internal medicine
language	en
locations[0].id	doi:10.2967/jnumed.116.182402
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210180780
locations[0].source.issn	2159-662X
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	2159-662X
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Journal of Nuclear Medicine
locations[0].source.host_organization	https://openalex.org/P4310315767
locations[0].source.host_organization_name	Society of Nuclear Medicine and Molecular Imaging
locations[0].source.host_organization_lineage	https://openalex.org/P4310315767
locations[0].source.host_organization_lineage_names	Society of Nuclear Medicine and Molecular Imaging
locations[0].license
locations[0].pdf_url	http://jnm.snmjournals.org/content/58/4/611.full.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Journal of Nuclear Medicine
locations[0].landing_page_url	https://doi.org/10.2967/jnumed.116.182402
locations[1].id	pmid:27789717
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Journal of nuclear medicine : official publication, Society of Nuclear Medicine
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/27789717
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5101500735
authorships[0].author.orcid	https://orcid.org/0000-0003-4378-4776
authorships[0].author.display_name	Chi‐Cheng Huang
authorships[0].countries	TW
authorships[0].affiliations[0].institution_ids	https://openalex.org/I4210129488
authorships[0].affiliations[0].raw_affiliation_string	Department of Surgery, Cathay General Hospital, Taipei, Taiwan
authorships[0].affiliations[1].institution_ids	https://openalex.org/I114150738
authorships[0].affiliations[1].raw_affiliation_string	School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
authorships[0].institutions[0].id	https://openalex.org/I4210129488
authorships[0].institutions[0].ror	https://ror.org/03c8c9n80
authorships[0].institutions[0].type	healthcare
authorships[0].institutions[0].lineage	https://openalex.org/I4210129488
authorships[0].institutions[0].country_code	TW
authorships[0].institutions[0].display_name	Cathay General Hospital
authorships[0].institutions[1].id	https://openalex.org/I114150738
authorships[0].institutions[1].ror	https://ror.org/04je98850
authorships[0].institutions[1].type	education
authorships[0].institutions[1].lineage	https://openalex.org/I114150738
authorships[0].institutions[1].country_code	TW
authorships[0].institutions[1].display_name	Fu Jen Catholic University
authorships[0].author_position	first
authorships[0].raw_author_name	Chi-Cheng Huang
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Surgery, Cathay General Hospital, Taipei, Taiwan, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
authorships[1].author.id	https://openalex.org/A5040976536
authorships[1].author.orcid	https://orcid.org/0000-0001-6851-7936
authorships[1].author.display_name	Chun‐Hu Wu
authorships[1].countries	TW
authorships[1].affiliations[0].institution_ids	https://openalex.org/I68171755
authorships[1].affiliations[0].raw_affiliation_string	Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
authorships[1].institutions[0].id	https://openalex.org/I68171755
authorships[1].institutions[0].ror	https://ror.org/02bn97g32
authorships[1].institutions[0].type	healthcare
authorships[1].institutions[0].lineage	https://openalex.org/I68171755
authorships[1].institutions[0].country_code	TW
authorships[1].institutions[0].display_name	National Defense Medical Center
authorships[1].author_position	middle
authorships[1].raw_author_name	Chun-Hu Wu
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
authorships[2].author.id	https://openalex.org/A5076496625
authorships[2].author.orcid	https://orcid.org/0000-0002-3460-7922
authorships[2].author.display_name	Ya-Yao Huang
authorships[2].countries	TW
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210131804
authorships[2].affiliations[0].raw_affiliation_string	Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan
authorships[2].institutions[0].id	https://openalex.org/I4210131804
authorships[2].institutions[0].ror	https://ror.org/03nteze27
authorships[2].institutions[0].type	healthcare
authorships[2].institutions[0].lineage	https://openalex.org/I4210131804
authorships[2].institutions[0].country_code	TW
authorships[2].institutions[0].display_name	National Taiwan University Hospital
authorships[2].author_position	middle
authorships[2].raw_author_name	Ya-Yao Huang
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan
authorships[3].author.id	https://openalex.org/A5044141560
authorships[3].author.orcid	https://orcid.org/0000-0002-5657-8579
authorships[3].author.display_name	Kai‐Yuan Tzen
authorships[3].countries	TW
authorships[3].affiliations[0].institution_ids	https://openalex.org/I4210131804
authorships[3].affiliations[0].raw_affiliation_string	Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan
authorships[3].institutions[0].id	https://openalex.org/I4210131804
authorships[3].institutions[0].ror	https://ror.org/03nteze27
authorships[3].institutions[0].type	healthcare
authorships[3].institutions[0].lineage	https://openalex.org/I4210131804
authorships[3].institutions[0].country_code	TW
authorships[3].institutions[0].display_name	National Taiwan University Hospital
authorships[3].author_position	middle
authorships[3].raw_author_name	Kai-Yuan Tzen
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan
authorships[4].author.id	https://openalex.org/A5003661682
authorships[4].author.orcid	https://orcid.org/0000-0002-8398-883X
authorships[4].author.display_name	Szu‐Fu Chen
authorships[4].countries	TW
authorships[4].affiliations[0].institution_ids	https://openalex.org/I4210101378
authorships[4].affiliations[0].raw_affiliation_string	Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan
authorships[4].affiliations[1].institution_ids	https://openalex.org/I68171755
authorships[4].affiliations[1].raw_affiliation_string	Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
authorships[4].institutions[0].id	https://openalex.org/I4210101378
authorships[4].institutions[0].ror	https://ror.org/014f77s28
authorships[4].institutions[0].type	healthcare
authorships[4].institutions[0].lineage	https://openalex.org/I4210101378
authorships[4].institutions[0].country_code	TW
authorships[4].institutions[0].display_name	Cheng Hsin General Hospital
authorships[4].institutions[1].id	https://openalex.org/I68171755
authorships[4].institutions[1].ror	https://ror.org/02bn97g32
authorships[4].institutions[1].type	healthcare
authorships[4].institutions[1].lineage	https://openalex.org/I68171755
authorships[4].institutions[1].country_code	TW
authorships[4].institutions[1].display_name	National Defense Medical Center
authorships[4].author_position	middle
authorships[4].raw_author_name	Szu-Fu Chen
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
authorships[5].author.id	https://openalex.org/A5038898531
authorships[5].author.orcid
authorships[5].author.display_name	Miao-Ling Tsai
authorships[5].countries	TW
authorships[5].affiliations[0].institution_ids	https://openalex.org/I114150738
authorships[5].affiliations[0].raw_affiliation_string	School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
authorships[5].institutions[0].id	https://openalex.org/I114150738
authorships[5].institutions[0].ror	https://ror.org/04je98850
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I114150738
authorships[5].institutions[0].country_code	TW
authorships[5].institutions[0].display_name	Fu Jen Catholic University
authorships[5].author_position	middle
authorships[5].raw_author_name	Miao-Ling Tsai
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
authorships[6].author.id	https://openalex.org/A5102163868
authorships[6].author.orcid
authorships[6].author.display_name	Hsiao-Ming Wu
authorships[6].countries	TW
authorships[6].affiliations[0].institution_ids	https://openalex.org/I114150738
authorships[6].affiliations[0].raw_affiliation_string	School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
authorships[6].institutions[0].id	https://openalex.org/I114150738
authorships[6].institutions[0].ror	https://ror.org/04je98850
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I114150738
authorships[6].institutions[0].country_code	TW
authorships[6].institutions[0].display_name	Fu Jen Catholic University
authorships[6].author_position	last
authorships[6].raw_author_name	Hsiao-Ming Wu
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	http://jnm.snmjournals.org/content/58/4/611.full.pdf
open_access.oa_status	bronze
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Performing Repeated Quantitative Small-Animal PET with an Arterial Input Function Is Routinely Feasible in Rats
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10522
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2741
primary_topic.subfield.display_name	Radiology, Nuclear Medicine and Imaging
primary_topic.display_name	Medical Imaging Techniques and Applications
related_works	https://openalex.org/W2074037842, https://openalex.org/W2075388011, https://openalex.org/W1965747368, https://openalex.org/W4301858053, https://openalex.org/W3023645862, https://openalex.org/W2081959309, https://openalex.org/W4246793367, https://openalex.org/W2023362998, https://openalex.org/W579219195, https://openalex.org/W2007125162
cited_by_count	7
counts_by_year[0].year	2024
counts_by_year[0].cited_by_count	1
counts_by_year[1].year	2021
counts_by_year[1].cited_by_count	1
counts_by_year[2].year	2020
counts_by_year[2].cited_by_count	2
counts_by_year[3].year	2019
counts_by_year[3].cited_by_count	1
counts_by_year[4].year	2018
counts_by_year[4].cited_by_count	2
locations_count	2
best_oa_location.id	doi:10.2967/jnumed.116.182402
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210180780
best_oa_location.source.issn	2159-662X
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	2159-662X
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Journal of Nuclear Medicine
best_oa_location.source.host_organization	https://openalex.org/P4310315767
best_oa_location.source.host_organization_name	Society of Nuclear Medicine and Molecular Imaging
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310315767
best_oa_location.source.host_organization_lineage_names	Society of Nuclear Medicine and Molecular Imaging
best_oa_location.license
best_oa_location.pdf_url	http://jnm.snmjournals.org/content/58/4/611.full.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Journal of Nuclear Medicine
best_oa_location.landing_page_url	https://doi.org/10.2967/jnumed.116.182402
primary_location.id	doi:10.2967/jnumed.116.182402
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210180780
primary_location.source.issn	2159-662X
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	2159-662X
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Journal of Nuclear Medicine
primary_location.source.host_organization	https://openalex.org/P4310315767
primary_location.source.host_organization_name	Society of Nuclear Medicine and Molecular Imaging
primary_location.source.host_organization_lineage	https://openalex.org/P4310315767
primary_location.source.host_organization_lineage_names	Society of Nuclear Medicine and Molecular Imaging
primary_location.license
primary_location.pdf_url	http://jnm.snmjournals.org/content/58/4/611.full.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Journal of Nuclear Medicine
primary_location.landing_page_url	https://doi.org/10.2967/jnumed.116.182402
publication_date	2016-10-27
publication_year	2016
referenced_works	https://openalex.org/W2005606566, https://openalex.org/W2094847554, https://openalex.org/W1999309928, https://openalex.org/W2114428276, https://openalex.org/W2047777363, https://openalex.org/W1982672672, https://openalex.org/W6657043173, https://openalex.org/W2090306035, https://openalex.org/W6640892438, https://openalex.org/W6681182844, https://openalex.org/W2054765812, https://openalex.org/W1994298948, https://openalex.org/W1966191914, https://openalex.org/W2288300369, https://openalex.org/W2148325823, https://openalex.org/W2127449611, https://openalex.org/W2064725661, https://openalex.org/W2104311964, https://openalex.org/W1998102975, https://openalex.org/W2346402454, https://openalex.org/W7000124399, https://openalex.org/W2094766762, https://openalex.org/W1951442280, https://openalex.org/W2142814256, https://openalex.org/W2143363204, https://openalex.org/W2027049681, https://openalex.org/W2465753597
referenced_works_count	27
abstract_inverted_index.2	65, 137
abstract_inverted_index.3	94
abstract_inverted_index.6	103, 126, 147
abstract_inverted_index.=	168
abstract_inverted_index.a	17, 22, 114, 123
abstract_inverted_index.12	130
abstract_inverted_index.6)	169
abstract_inverted_index.On	125
abstract_inverted_index.We	29
abstract_inverted_index.an	5, 118, 195
abstract_inverted_index.be	200
abstract_inverted_index.by	40
abstract_inverted_index.in	38, 51, 183
abstract_inverted_index.is	186
abstract_inverted_index.it	42
abstract_inverted_index.of	33, 49, 56, 71, 107, 154
abstract_inverted_index.on	64, 136
abstract_inverted_index.to	44, 172
abstract_inverted_index.we	15, 128
abstract_inverted_index.±	163
abstract_inverted_index.1.5	27
abstract_inverted_index.PET	3, 37, 102, 134, 150, 192
abstract_inverted_index.The	80, 105, 139, 152
abstract_inverted_index.and	76, 87, 117, 144
abstract_inverted_index.can	199
abstract_inverted_index.for	26, 174
abstract_inverted_index.has	9
abstract_inverted_index.mo.	28
abstract_inverted_index.not	187
abstract_inverted_index.rat	23, 68, 97
abstract_inverted_index.the	31, 46, 52, 72, 92, 146, 155
abstract_inverted_index.was	62, 111, 170
abstract_inverted_index.wk,	95
abstract_inverted_index.10.2	164
abstract_inverted_index.99.6	162
abstract_inverted_index.Each	67
abstract_inverted_index.Over	91
abstract_inverted_index.been	10
abstract_inverted_index.each	96, 108
abstract_inverted_index.good	180
abstract_inverted_index.grew	141
abstract_inverted_index.left	77
abstract_inverted_index.next	93
abstract_inverted_index.rate	55
abstract_inverted_index.rats	39, 140, 185
abstract_inverted_index.that	20, 121, 173
abstract_inverted_index.then	88
abstract_inverted_index.time	47
abstract_inverted_index.were	82
abstract_inverted_index.with	4, 84, 194
abstract_inverted_index.Here,	14
abstract_inverted_index.after	145
abstract_inverted_index.blood	181
abstract_inverted_index.brain	109, 157
abstract_inverted_index.input	7, 197
abstract_inverted_index.keeps	21
abstract_inverted_index.model	116
abstract_inverted_index.ports	86
abstract_inverted_index.rats.	66, 138
abstract_inverted_index.right	73, 159
abstract_inverted_index.using	113
abstract_inverted_index.vein.	79
abstract_inverted_index.(e.g.,	158
abstract_inverted_index.artery	75
abstract_inverted_index.before	143
abstract_inverted_index.course	48
abstract_inverted_index.g/min;	166
abstract_inverted_index.region	110
abstract_inverted_index.sealed	83
abstract_inverted_index.stable	25
abstract_inverted_index.times.	104
abstract_inverted_index.Aseptic	60
abstract_inverted_index.femoral	74, 78
abstract_inverted_index.glucose	57
abstract_inverted_index.imaging	193
abstract_inverted_index.monitor	45
abstract_inverted_index.patency	182
abstract_inverted_index.region,	161
abstract_inverted_index.studies	135
abstract_inverted_index.surgery	61
abstract_inverted_index.<i>n</i>	167
abstract_inverted_index.arterial	6, 196
abstract_inverted_index.cerebral	53
abstract_inverted_index.equation	120
abstract_inverted_index.function	8, 198
abstract_inverted_index.included	122
abstract_inverted_index.methods.	177
abstract_inverted_index.parietal	160
abstract_inverted_index.steadily	142
abstract_inverted_index.studies.	151
abstract_inverted_index.catheters	81
abstract_inverted_index.completed	129
abstract_inverted_index.conscious	156
abstract_inverted_index.implanted	89
abstract_inverted_index.introduce	16
abstract_inverted_index.metabolic	54
abstract_inverted_index.mornings,	127
abstract_inverted_index.performed	63, 201
abstract_inverted_index.procedure	19
abstract_inverted_index.underwent	69, 98
abstract_inverted_index.μmol/100	165
abstract_inverted_index.Performing	0
abstract_inverted_index.calculated	112
abstract_inverted_index.comparable	171
abstract_inverted_index.considered	11
abstract_inverted_index.difficult.	188
abstract_inverted_index.performing	41
abstract_inverted_index.repeatedly	43
abstract_inverted_index.routinely.	202
abstract_inverted_index.variations	50
abstract_inverted_index.Maintaining	179
abstract_inverted_index.feasibility	32
abstract_inverted_index.operational	119
abstract_inverted_index.technically	12
abstract_inverted_index.Longitudinal	189
abstract_inverted_index.catheterized	184
abstract_inverted_index.challenging.	13
abstract_inverted_index.demonstrated	30
abstract_inverted_index.quantitative	1, 34, 100, 132, 148, 190
abstract_inverted_index.small-animal	2, 35, 101, 133, 149, 191
abstract_inverted_index.3-compartment	115
abstract_inverted_index.microinjection	85
abstract_inverted_index.<b>Methods:</b>	59
abstract_inverted_index.catheterization	18, 70
abstract_inverted_index.physiologically	24
abstract_inverted_index.subcutaneously.	90
abstract_inverted_index.autoradiographic	176
abstract_inverted_index.CMR<sub>glc</sub>	106, 153
abstract_inverted_index.<b>Conclusion:</b>	178
abstract_inverted_index.<sup>18</sup>F-FDG	36, 99, 131
abstract_inverted_index.(CMR<sub>glc</sub>).	58
abstract_inverted_index.<sup>14</sup>C-deoxyglucose	175
abstract_inverted_index.<i>k*</i><sub><i>4</i></sub><b>Results:</b>	124
cited_by_percentile_year.max	96
cited_by_percentile_year.min	89
countries_distinct_count	1
institutions_distinct_count	7
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.5
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.77707745
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False