Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioning Article Swipe
Adam X. Gorka
,
Ryan T. Philips
,
Salvatore Torrisi
,
Adrienne Manbeck
,
Madeline Goodwin
,
Monique Ernst
,
Christian Grillon
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/scan/nsad025
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/scan/nsad025
Computational models of associative learning posit that negative prediction errors (PEs) arising from the omission of aversive outcomes weaken aversive Pavlovian associations during differential conditioning and extinction. It is possible that negative PEs may underlie exaggerated conditioned responses to the conditioned stimulus not paired with an aversitve outcome (CS-) during differential conditioning and to the conditioned stimulus originally paired with a aversive outcome (CS+) during extinction in patients with clinical anxiety disorders. Although previous research has demonstrated that manipulations of the periaqueductal gray matter (PAG) interfere with extinction learning in animals, the role of the PAG in processing negative PEs within the human brain is presently unclear. We set out to investigate how PAG responses and connectivity are impacted by negative PEs using ultra-high-field (7 T) functional magnetic resonance imaging and hierarchical Bayesian analysis. During differential conditioning, negative PEs were associated with larger responses within the lateral and dorsolateral PAG and increased connectivity between the dorsolateral PAG and medial areas of Brodmann area 9. Collectively, these results shed light on the association between activity within the PAG and medial prefrontal cortex and the omission of aversive outcomes during Pavlovian learning.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/scan/nsad025
- https://academic.oup.com/scan/article-pdf/18/1/nsad025/50425144/nsad025.pdf
- OA Status
- gold
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4376121184
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4376121184Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/scan/nsad025Digital Object Identifier
- Title
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Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioningWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
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2023-01-01Full publication date if available
- Authors
-
Adam X. Gorka, Ryan T. Philips, Salvatore Torrisi, Adrienne Manbeck, Madeline Goodwin, Monique Ernst, Christian GrillonList of authors in order
- Landing page
-
https://doi.org/10.1093/scan/nsad025Publisher landing page
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https://academic.oup.com/scan/article-pdf/18/1/nsad025/50425144/nsad025.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/scan/article-pdf/18/1/nsad025/50425144/nsad025.pdfDirect OA link when available
- Concepts
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Psychology, Prefrontal cortex, Periaqueductal gray, Gray (unit), Neuroscience, Conditioning, Midbrain, Central nervous system, Cognition, Medicine, Mathematics, Radiology, StatisticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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79Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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