Dendritic cells give mast cells a nudge Anaphylaxis is a life-threatening allergic reaction triggered after antigen-specific immunoglobulin E (IgE) antibodies bind to target allergens. These antibodies then cross-link IgE-specific Fc receptors on the surface of mast cells. The mast cells rapidly release inflammatory mediators, including histamine, resulting in smooth muscle contraction, vasodilation, and blood vessel leakage. Because mast cells are usually found in the perivascular abluminal surface of blood vesse…