Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes Article Swipe
Giacomo Della Camera
,
Mariusz P. Madej
,
Anna Maria Ferretti
,
Rita La Spina
,
Yang Li
,
Annunziata Corteggio
,
Tommaso Heinzl
,
Benjamin J. Swartzwelter
,
Gergö Sipos
,
Sabrina Gioria
,
Alessandro Ponti
,
Diana Boraschi
,
Paola Italiani
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.692165
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.692165
Engineered nanoparticles used for medical purposes must meet stringent safety criteria, which include immunosafety, i.e. , the inability to activate possibly detrimental immune/inflammatory effects. Even medical nanomaterials devoid of direct immunotoxic or inflammatory effects may have an impact on human health if able to modify innate memory, which is the ability to “prime” future immune responses towards a different, possibly more detrimental reactivity. Although innate memory is usually protective, anomalous innate memory responses may be at the basis of immune pathologies. In this study, we have examined the ability of two nanomaterials commonly used for diagnostic imaging purposes, gold and iron oxide nanoparticles, to induce or modulate innate memory, using an in vitro model based on human primary monocytes. Monocytes were exposed in culture to nanoparticles alone or together with the bacterial agent LPS (priming phase/primary response), then rested for six days (extinction phase), and eventually challenged with LPS (memory/secondary response). The memory response to the LPS challenge was measured as changes in the production of inflammatory (TNFα, IL-6) and anti-inflammatory cytokines (IL-10, IL-1Ra), as compared to unprimed monocytes. The results show that both types of nanoparticles can have an effect in the induction of memory, with changes observed in the cytokine production. By comparing nanomaterials of different shapes (spherical vs . rod-shaped gold particles) and different size (17 vs . 22 nm diameter spherical iron oxide particles), it was evident that innate memory could be differentially induced and modulated depending on size, shape and chemical composition. However, the main finding was that the innate memory effect of the particles was strongly donor-dependent, with monocytes from each donor showing a distinct memory profile upon priming with the same particles, thereby making impossible to draw general conclusions on the particle effects. Thus, in order to predict the effect of imaging nanoparticles on the innate memory of patients, a personalised profiling would be required, able to take in consideration the peculiarities of the individual innate immune reactivity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2021.692165
- OA Status
- gold
- Cited By
- 11
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3190806207
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3190806207Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2021.692165Digital Object Identifier
- Title
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Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human MonocytesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-08-06Full publication date if available
- Authors
-
Giacomo Della Camera, Mariusz P. Madej, Anna Maria Ferretti, Rita La Spina, Yang Li, Annunziata Corteggio, Tommaso Heinzl, Benjamin J. Swartzwelter, Gergö Sipos, Sabrina Gioria, Alessandro Ponti, Diana Boraschi, Paola ItalianiList of authors in order
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https://doi.org/10.3389/fimmu.2021.692165Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fimmu.2021.692165Direct OA link when available
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Innate immune system, Immune system, Inflammation, Immunology, BiologyTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2024: 1, 2023: 3, 2022: 3, 2021: 4Per-year citation counts (last 5 years)
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73Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2021-08-06 |
| publication_year | 2021 |
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