Personalized pulmonary vein antrum isolation guided by left atrial wall thickness for persistent atrial fibrillation Article Swipe
Giulio Falasconi
,
Diego Penela
,
David Soto‐Iglesias
,
Pietro Francia
,
Cheryl Terés
,
Andrea Saglietto
,
Beatriz Jáuregui
,
Daniel Viveros
,
A Bellido
,
José Alderete
,
Julia Meca-Santamaria
,
Paula Franco
,
Carlo Gaspardone
,
Rodolfo San Antonio
,
Marina Huguet
,
Óscar Cámara
,
José T. Ortiz‐Perez
,
Julio Martí‐Almor
,
Antonio Berruezo
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/europace/euad118
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/europace/euad118
Aims Pulmonary vein (PV) antrum isolation proved to be effective for treating persistent atrial fibrillation (PeAF). We sought to investigate the results of a personalized approach aimed at adapting the ablation index (AI) to the local left atrial wall thickness (LAWT) in a cohort of consecutive patients with PeAF. Methods and results Consecutive patients referred for PeAF first ablation were prospectively enrolled. The LAWT three-dimensional maps were obtained from pre-procedure multidetector computed tomography and integrated into the navigation system. Ablation index was titrated according to the local LAWT, and the ablation line was personalized to avoid the thickest regions while encircling the PV antrum. A total of 121 patients (69.4% male, age 64.5 ± 9.5 years) were included. Procedure time was 57 min (IQR 50–67), fluoroscopy time was 43 s (IQR 20–71), and radiofrequency (RF) time was 16.5 min (IQR 14.3–18.4). The median AI tailored to the local LAWT was 387 (IQR 360–410) for the anterior wall and 335 (IQR 300–375) for the posterior wall. First-pass PV antrum isolation was obtained in 103 (85%) of the right PVs and 103 (85%) of the left PVs. Median LAWT values were higher for PVs without first-pass isolation as compared to the whole cohort (P = 0.02 for left PVs and P = 0.03 for right PVs). Recurrence-free survival was 79% at 12 month follow-up. Conclusion In this prospective study, LAWT-guided PV antrum isolation for PeAF was effective and efficient, requiring low procedure, fluoroscopy, and RF time. A randomized trial comparing the LAWT-guided ablation with the standard of practice is in progress (ClinicalTrials.gov, NCT05396534).
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/europace/euad118
- https://academic.oup.com/europace/article-pdf/25/5/euad118/50487577/euad118.pdf
- OA Status
- hybrid
- Cited By
- 26
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367601986
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4367601986Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/europace/euad118Digital Object Identifier
- Title
-
Personalized pulmonary vein antrum isolation guided by left atrial wall thickness for persistent atrial fibrillationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-01Full publication date if available
- Authors
-
Giulio Falasconi, Diego Penela, David Soto‐Iglesias, Pietro Francia, Cheryl Terés, Andrea Saglietto, Beatriz Jáuregui, Daniel Viveros, A Bellido, José Alderete, Julia Meca-Santamaria, Paula Franco, Carlo Gaspardone, Rodolfo San Antonio, Marina Huguet, Óscar Cámara, José T. Ortiz‐Perez, Julio Martí‐Almor, Antonio BerruezoList of authors in order
- Landing page
-
https://doi.org/10.1093/europace/euad118Publisher landing page
- PDF URL
-
https://academic.oup.com/europace/article-pdf/25/5/euad118/50487577/euad118.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/europace/article-pdf/25/5/euad118/50487577/euad118.pdfDirect OA link when available
- Concepts
-
Medicine, Atrial fibrillation, Pulmonary vein, Antrum, Cardiology, Internal medicine, Isolation (microbiology), Bioinformatics, Biology, StomachTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
26Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 8, 2023: 9Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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