Perspective Chapter: Oxidative Stress in MAFLD Article Swipe
Related Concepts
No concepts available.
Oana Timofte
,
Alexandru Sidencu
,
Lilia Lica
,
Elena Gologan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5772/intechopen.1012216
· OA: W4414070645
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5772/intechopen.1012216
· OA: W4414070645
Oxidative stress is a key driver in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). Characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, oxidative stress leads to cellular damage and progression of liver pathology. It is commonly observed in metabolic syndromes including obesity, type 2 diabetes mellitus (T2DM), and dyslipidemia. This review provides an in-depth discussion on the mechanisms linking oxidative stress and MAFLD progression, focusing on mitochondrial dysfunction, immune activation, genetic predispositions, and potential therapeutic interventions. Understanding these pathways is essential for the development of targeted therapies.
Related Topics
Finding more related topics…