Pharmaceutical activity of a synthetic heterocyclic (C<sub>15</sub>H<sub>12</sub>N<sub>5</sub>OCl) compound on <i>Entamoeba histolytica</i> and <i>Giardia lamblia</i> Article Swipe
Hiro Mohammed Obaid
,
S. Sale
,
Larson Boundenga
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.15789/2220-7619-pao-2024
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.15789/2220-7619-pao-2024
Background. Intestinal parasites are among the most important infectious agents with an impact on human health. Indeed, in the lack of an available treatment option, these parasites could constitute a real health problem in the population. In the present study, we investigated for the first time the effect of a novel synthetic heterocyclic ((C15H12N5OCL)2-(benzo(d)(1,2,3)triazol-1-yl)-N-benzylideneacetohydrazine) compound on two intestinal parasites (Entamoeba histolytica and Giardia lamblia). Methods. The parasite isolates tested were collected from outpatients at the General Pediatric Hospital in Kirkuk, Iraq, between September 2019 and January 2020. Thus, we studied the in vivo and in vitro pharmaceutical activity of the ingredient on both parasites. The toxicological effects of the substance on some blood parameters and liver and kidney function tests were also studied. Results. After five days of treatment, the drugs in vivo action on G. lamblia resulted in an inhibition rate of 88.2% at a dose of 1 mg/kg. On the other hand, we observed that the influence of this synthetic substance on cultured E. histolytica was very close to the metronidazole effect. The maximum result was at a concentration of 1 g/ml and was obtained after 72 hours of incubation with an inhibition rate of 89.4%. The substance did not affect the blood parameters or the studied liver and kidney functions. Conclusion. It can be concluded that this substance is highly effective against both E. histolytica and G. lamblia, and that it has no toxic effects on the studied parameters. Therefore, it could be a promising pharmacophore for intestinal protozoan parasites including E. histolytica and G. lamblia and an alternative or competitor to the current medications available.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.15789/2220-7619-pao-2024
- https://iimmun.ru/iimm/article/download/2024/1689
- OA Status
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- Cited By
- 3
- References
- 32
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4323359996Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.15789/2220-7619-pao-2024Digital Object Identifier
- Title
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Pharmaceutical activity of a synthetic heterocyclic (C<sub>15</sub>H<sub>12</sub>N<sub>5</sub>OCl) compound on <i>Entamoeba histolytica</i> and <i>Giardia lamblia</i>Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-07Full publication date if available
- Authors
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Hiro Mohammed Obaid, S. Sale, Larson BoundengaList of authors in order
- Landing page
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https://doi.org/10.15789/2220-7619-pao-2024Publisher landing page
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https://iimmun.ru/iimm/article/download/2024/1689Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://iimmun.ru/iimm/article/download/2024/1689Direct OA link when available
- Concepts
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Giardia lamblia, Entamoeba histolytica, In vivo, Metronidazole, Population, In vitro, Pharmacology, Incubation, Chemistry, Biology, Microbiology, Medicine, Antibiotics, Biochemistry, Biotechnology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2024: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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