Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology Article Swipe
Noha Mousaad Elemam
,
Radwa Y. Mekky
,
Gowhar Rashid
,
Maria Braoudaki
,
R.A. Youness
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1017/erm.2023.26
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1017/erm.2023.26
The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. Taking a closer look at the tumour-immune microenvironment, a complex network and crosstalk between infiltrating immune cells and cancer cells mediated by cytokines, chemokines, exosomal mediators and shed ligands are present. Cytokines such as interleukins can influence all components of the tumour microenvironment (TME), consequently promoting or suppressing tumour invasion based on their secreting source. Interleukin-10 (IL-10) is an interlocked cytokine that has been associated with several types of malignancies and proved to have paradoxical effects. IL-10 has multiple functions on cellular and non-cellular components within the TME. In this review, the authors shed the light on the regulatory role of IL-10 in the TME of several malignant contexts. Moreover, detailed epigenomic and pharmacogenomic approaches for the regulation of IL-10 were presented and discussed.
Related Topics
Concepts
Epigenomics
Tumor microenvironment
Immune system
Chemokine
Cytokine
Crosstalk
Metastasis
Cancer research
Immunology
Biology
Medicine
Cancer
DNA methylation
Gene expression
Genetics
Optics
Gene
Physics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1017/erm.2023.26
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C59F7BD49C05828406D61500D476670A/S1462399423000261a.pdf/div-class-title-pharmacogenomic-and-epigenomic-approaches-to-untangle-the-enigma-of-il-10-blockade-in-oncology-div.pdf
- OA Status
- diamond
- Cited By
- 12
- References
- 245
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390667591
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390667591Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1017/erm.2023.26Digital Object Identifier
- Title
-
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncologyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
-
Noha Mousaad Elemam, Radwa Y. Mekky, Gowhar Rashid, Maria Braoudaki, R.A. YounessList of authors in order
- Landing page
-
https://doi.org/10.1017/erm.2023.26Publisher landing page
- PDF URL
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C59F7BD49C05828406D61500D476670A/S1462399423000261a.pdf/div-class-title-pharmacogenomic-and-epigenomic-approaches-to-untangle-the-enigma-of-il-10-blockade-in-oncology-div.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C59F7BD49C05828406D61500D476670A/S1462399423000261a.pdf/div-class-title-pharmacogenomic-and-epigenomic-approaches-to-untangle-the-enigma-of-il-10-blockade-in-oncology-div.pdfDirect OA link when available
- Concepts
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Epigenomics, Tumor microenvironment, Immune system, Chemokine, Cytokine, Crosstalk, Metastasis, Cancer research, Immunology, Biology, Medicine, Cancer, DNA methylation, Gene expression, Genetics, Optics, Gene, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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245Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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