Pharmacognostical Analysis and Protective Effect of Standardized Extract and Rizonic Acid from Erythrina velutina against 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells. Article Swipe
Aline H. Silva
,
Francisco Noé da Fonseca
,
Antônia Torres Ávila Pimenta
,
MaryAnne S Lima
,
Edilberto R. Silveira
,
Glauce Socorro de Barros Viana
,
Silvânia Maria Mendes Vasconcelos
,
Luzia Kalyne Almeida Moreira Leal
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.4103/0973-1296.192200
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.4103/0973-1296.192200
The powder of Erythrina velutina was classified as moderately coarse and several quality-control parameters were determined.Ethanolic extract from E. velutina (EEEV) produced by percolation gave the highest phenol content when related to others extractive methods and its HPLC-PDA analysis of EEEV allowed to identify four flavonoids and rizonic acid (RA), some reported for the first time for the species.The EEEV and RA reduced significantly the neurotoxicity induced by 6-OHDA in SH-SY5Y cells determined by the MTT assay and the nitrite concentration.The EEEV also showed a free radical scavenging activity. Abbreviations used: ±: More or less, %: Percentage, °C: Degree Celsius, 2Cl2: Dichloromethane, CHCl3: Chloroform cmCentimeter, DMEM/F12: Dulbecco's Modified Eagle's Medium: Nutrient Mixture F-12. DMSO: Dimethyl sulfoxide, DPPH: 1,1-Diphenyl-2-picrylhydrazyl, EAG: Gallic acid equivalents, EEEV: Ethanolic extract of Erythrina velutina, EtOAc: Ethyl acetate, g: Gram, h: Hour, H2O: Water, HPLC: High-performance liquid chromatography, H REIMS: Hydrogen rapid evaporative ionization mass spectrometry, Kg: Kilogram M: Molar, m: Metro, MeOH: Methanol, mg: Milligram, min: Minute, mL: Milliliter, mm: Millimeter, MTT: Bromide 3 [4,5-dimethylthiazol-2-yl] -2,5-diphenyltetrazolium, N: Normal, NBT: Nitroblue tetrazolium, nm: Nanometer, PDA: Photodiode array detector, TPC: Total polyphenol content, RA: Rizonic acid, RP: Reverse phase, SOD: Superoxide dismutase, v/v: Volume per volume, Vs: Versus W: Watts.
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- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/27867274
- OA Status
- green
- Cited By
- 14
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2549284259
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2549284259Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/0973-1296.192200Digital Object Identifier
- Title
-
Pharmacognostical Analysis and Protective Effect of Standardized Extract and Rizonic Acid from Erythrina velutina against 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells.Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-01-01Full publication date if available
- Authors
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Aline H. Silva, Francisco Noé da Fonseca, Antônia Torres Ávila Pimenta, MaryAnne S Lima, Edilberto R. Silveira, Glauce Socorro de Barros Viana, Silvânia Maria Mendes Vasconcelos, Luzia Kalyne Almeida Moreira LealList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/27867274Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.4103/0973-1296.192200Direct OA link when available
- Concepts
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Neuroprotection, Hydroxydopamine, Neurotoxicity, Pharmacology, Chemistry, Traditional medicine, Biology, Toxicity, Medicine, Dopamine, Dopaminergic, Neuroscience, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 5, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
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15Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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