Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced Ultrasound Article Swipe
Chuan Chen
,
Reshani Perera
,
Michael C. Kolios
,
Hessel Wijkstra
,
Agata A. Exner
,
Massimo Mischi
,
Simona Turco
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.32920/27913419.v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.32920/27913419.v1
With a typical 100-500 nm diameter, nanobubbles are a promising new-generation ultrasound contrast agent that paves ways for several applications, such as efficient drug delivery, molecular imaging, and assessment of vascular permeability. Due to their unique physical properties, nanobubbles exhibit distinct in vivo pharmacokinetics. We have shown that the first pass of the nanobubble bolus is usually accompanied by the appearance of a second bolus (wave) within a time range of about 15 minutes. Such phenomenon, to the best of our knowledge, has never been observed with conventional microbubbles and smaller molecular contrast agents used in MRI and CT. In a previous study, we showed the potential of this phenomenon in supporting cancer diagnosis. This study focuses on developing a new compartmental pharmacokinetic model that can be used to interpret the second-wave phenomenon. With this model, we can analyze more in-depth the roles of several physiological factors affecting the characteristics of the second-wave phenomenon.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.32920/27913419.v1
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
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- OpenAlex ID
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https://openalex.org/W4404731979Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.32920/27913419.v1Digital Object Identifier
- Title
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Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced UltrasoundWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-27Full publication date if available
- Authors
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Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner, Massimo Mischi, Simona TurcoList of authors in order
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https://doi.org/10.32920/27913419.v1Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://figshare.com/articles/journal_contribution/Pharmacokinetic_Modeling_of_the_Second-Wave_Phenomenon_in_Nanobubble-Based_Contrast-Enhanced_Ultrasound/27913419Direct OA link when available
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Contrast (vision), Ultrasound, Phenomenon, Contrast-enhanced ultrasound, Materials science, Biomedical engineering, Medicine, Radiology, Optics, Physics, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |