Pharmacological interventions to diminish cognitive side effects of electroconvulsive therapy: A systematic review and meta‐analysis Article Swipe
Joey Verdijk
,
Mike A. van Kessel
,
Matthijs Oud
,
Charles H. Kellner
,
Jeannette Hofmeijer
,
Esmée Verwijk
,
Jeroen A. van Waarde
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/acps.13397
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/acps.13397
Objective The authors conducted a systematic review and meta‐analysis of pharmacological interventions to diminish cognitive side effects of ECT. Methods Electronic databases of Pubmed, PsycInfo, Embase and Scopus were searched from inception through 1 April, 2021, using terms for ECT (e.g. electroconvulsive therapy ), cognitive outcome (e.g. cogni* ) and pharmacological intervention (e.g. calcium channel blocker and general terms, like protein ). Original studies with humans receiving ECT were included, which applied pharmacological interventions in comparison with placebo or no additive intervention to diminish cognitive side effects. Data quality was assessed using Risk of Bias and GRADE. Random‐effects models were used. PROSPERO registration number was CRD42021212773. Results Qualitative synthesis (systematic review) showed 52 studies reporting sixteen pharmacological intervention‐types. Quantitative synthesis (meta‐analysis) included 26 studies (1387 patients) describing twelve pharmacological intervention‐types. Low‐quality evidence of efficacy was established for memantine (large effect size) and liothyronine (medium effect size). Very low‐quality evidence shows effect of acetylcholine inhibitors, piracetam and melatonin in some cognitive domains. Evidence of no efficacy was revealed for ketamine (very low‐quality), herbal preparations with anti‐inflammatory properties (very low to low‐quality) and opioid receptor agonists (low‐quality). Conclusion Memantine and liothyronine are promising for further research and future application. Quality of evidence was low because of differences in ECT techniques, study populations and cognitive measurements. These findings provide a guide for rational choices of potential pharmacological intervention research targets to decrease the burden of cognitive side effects of ECT. Future research should be more uniform in design and attempt to clarify pathophysiological mechanisms of cognitive side effects of ECT.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/acps.13397
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.13397
- OA Status
- hybrid
- Cited By
- 23
- References
- 94
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4207063168
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4207063168Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/acps.13397Digital Object Identifier
- Title
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Pharmacological interventions to diminish cognitive side effects of electroconvulsive therapy: A systematic review and meta‐analysisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-24Full publication date if available
- Authors
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Joey Verdijk, Mike A. van Kessel, Matthijs Oud, Charles H. Kellner, Jeannette Hofmeijer, Esmée Verwijk, Jeroen A. van WaardeList of authors in order
- Landing page
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https://doi.org/10.1111/acps.13397Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.13397Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.13397Direct OA link when available
- Concepts
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Memantine, Meta-analysis, Psychological intervention, Electroconvulsive therapy, Medicine, Cognition, Psychology, Systematic review, Clinical psychology, Psychiatry, MEDLINE, Internal medicine, Dementia, Political science, Law, DiseaseTop concepts (fields/topics) attached by OpenAlex
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23Total citation count in OpenAlex
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2025: 3, 2024: 7, 2023: 10, 2022: 3Per-year citation counts (last 5 years)
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94Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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