Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists Article Swipe
M Dirks
,
Owen M. McDougal
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ph17010123
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ph17010123
Veratrum californicum contains steroidal alkaloids that function as inhibitors of hedgehog (Hh) signaling, a pathway involved in the growth and differentiation of cells and normal tissue development. This same Hh pathway is abnormally active for cell proliferation in more than 20 types of cancer. In this current study, alkaloids have been extracted from the root and rhizome of V. californicum, followed by their separation into five fractions using high performance liquid chromatography. Mass spectrometry was used to identify the presence of twenty-five alkaloids, nine more than are commonly cited in literature reports, and the Bruker Compass Data Analysis software was used to predict the molecular formula for every detected alkaloid. The Gli activity of the raw extract and each fraction were compared to 0.1 µM cyclopamine, and fractions 1, 2, and 4 showed increased bioactivity through suppression of the Hh signaling pathway. Fractions 2 and 4 had enhanced bioactivity, but fraction 1 was most effective in inhibiting Hh signaling. The composition of fraction 1 consisted of veratrosine, cycloposine, and potential isomers of each.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph17010123
- https://www.mdpi.com/1424-8247/17/1/123/pdf?version=1705492082
- OA Status
- gold
- Cited By
- 2
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390944697
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390944697Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ph17010123Digital Object Identifier
- Title
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Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway AntagonistsWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
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2024-01-17Full publication date if available
- Authors
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M Dirks, Owen M. McDougalList of authors in order
- Landing page
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https://doi.org/10.3390/ph17010123Publisher landing page
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https://www.mdpi.com/1424-8247/17/1/123/pdf?version=1705492082Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1424-8247/17/1/123/pdf?version=1705492082Direct OA link when available
- Concepts
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Cyclopamine, Hedgehog, Rhizome, Hedgehog signaling pathway, Alkaloid, Chemistry, Signal transduction, Pharmacology, Botany, Biology, Stereochemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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50Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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