Phase-sensitive interferometry of decorrelated speckle patterns Article Swipe
Hendrik Spahr
,
Clara Pfäffle
,
Sazan Burhan
,
Lisa Kutzner
,
Felix Hilge
,
Gereon Hüttmann
,
Dierck Hillmann
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-019-47979-8
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-019-47979-8
Phase-sensitive coherent imaging exploits changes in the phases of backscattered light to observe tiny alterations of scattering structures or variations of the refractive index. But moving scatterers or a fluctuating refractive index decorrelate the phases and speckle patterns in the images. It is generally believed that once the speckle pattern has changed, the phases are scrambled and any meaningful phase difference to the original pattern is removed. As a consequence, diffusion and tissue motion that cannot be resolved, prevent phase-sensitive imaging of biological specimens. Here, we show that a phase comparison between decorrelated speckle patterns is still possible by utilizing a series of images acquired during decorrelation. The resulting evaluation scheme is mathematically equivalent to methods for astronomic imaging through the turbulent sky by speckle interferometry. We thus adopt the idea of speckle interferometry to phase-sensitive imaging in biological tissues and demonstrate its efficacy for simulated data and imaging of photoreceptor activity with phase-sensitive optical coherence tomography. We believe the described methods can be applied to many imaging modalities that use phase values for interferometry.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-019-47979-8
- https://www.nature.com/articles/s41598-019-47979-8.pdf
- OA Status
- gold
- Cited By
- 22
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2968455364
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2968455364Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-019-47979-8Digital Object Identifier
- Title
-
Phase-sensitive interferometry of decorrelated speckle patternsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-08-13Full publication date if available
- Authors
-
Hendrik Spahr, Clara Pfäffle, Sazan Burhan, Lisa Kutzner, Felix Hilge, Gereon Hüttmann, Dierck HillmannList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-019-47979-8Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-019-47979-8.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41598-019-47979-8.pdfDirect OA link when available
- Concepts
-
Speckle pattern, Interferometry, Speckle imaging, Decorrelation, Optics, Optical coherence tomography, Phase (matter), Speckle noise, Coherence (philosophical gambling strategy), Refractive index, Physics, Computer science, Computer vision, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 4, 2023: 2, 2022: 3, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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