PHD3 affects gastric cancer progression by negatively regulating HIF1A Article Swipe
Yingjie Xia
,
Xiaoting Jiang
,
Shibin Jiang
,
Xujun He
,
Jungang Luo
,
Zhengchuang Liu
,
Liang Wang
,
Hou‐Quan Tao
,
Jian-Zhong Chen
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2017.7455
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2017.7455
Prolyl hydroxylase 3 (PHD3) is widely accepted as a tumor suppressor; however, the expression of PHD3 in various cancer types remains controversial. The present study aimed to investigate the association between PHD3 expression and the clinicopathological features of gastric cancer using reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. The effects of PHD3 in gastric cancer cell lines were assessed using western blot analysis and transwell migration assays. The present results revealed that PHD3 expression was increased in adjacent non‑cancerous tissue compared with in gastric cancer tissue, and PHD3 overexpression was correlated with the presence of well‑differentiated cancer cells, early cancer stage classification and the absence of lymph node metastasis. In vitro experiments demonstrated that PHD3 may act as a negative regulator of hypoxia‑inducible factor‑1α and vascular endothelial growth factor, both of which participate in tumor angiogenesis. In conclusion, the present results suggested that PHD3 may act as a tumor suppressor in gastric cancer. Therefore, the targeted regulation of PHD3 may have potential as a novel therapeutic approach for the treatment of patients with gastric cancer.
Related Topics
Concepts
Cancer
Oncogene
HIF1A
Biology
Cancer research
Immunohistochemistry
Cancer cell
Angiogenesis
Molecular medicine
Metastasis
Cell cycle
Pathology
Medicine
Immunology
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/mmr.2017.7455
- http://www.spandidos-publications.com/10.3892/mmr.2017.7455/download
- OA Status
- bronze
- Cited By
- 26
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2754104139
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2754104139Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/mmr.2017.7455Digital Object Identifier
- Title
-
PHD3 affects gastric cancer progression by negatively regulating HIF1AWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-05-01Full publication date if available
- Authors
-
Yingjie Xia, Xiaoting Jiang, Shibin Jiang, Xujun He, Jungang Luo, Zhengchuang Liu, Liang Wang, Hou‐Quan Tao, Jian-Zhong ChenList of authors in order
- Landing page
-
https://doi.org/10.3892/mmr.2017.7455Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/mmr.2017.7455/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.spandidos-publications.com/10.3892/mmr.2017.7455/downloadDirect OA link when available
- Concepts
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Cancer, Oncogene, HIF1A, Biology, Cancer research, Immunohistochemistry, Cancer cell, Angiogenesis, Molecular medicine, Metastasis, Cell cycle, Pathology, Medicine, Immunology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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26Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 3, 2023: 4, 2022: 4, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.vitro | 110 |
| abstract_inverted_index.which | 131 |
| abstract_inverted_index.(PHD3) | 3 |
| abstract_inverted_index.Prolyl | 0 |
| abstract_inverted_index.cancer | 18, 39, 54, 84, 96, 99 |
| abstract_inverted_index.cells, | 97 |
| abstract_inverted_index.growth | 127 |
| abstract_inverted_index.tissue | 79 |
| abstract_inverted_index.widely | 5 |
| abstract_inverted_index.absence | 104 |
| abstract_inverted_index.assays. | 66 |
| abstract_inverted_index.between | 30 |
| abstract_inverted_index.cancer. | 152, 174 |
| abstract_inverted_index.effects | 49 |
| abstract_inverted_index.factor, | 128 |
| abstract_inverted_index.gastric | 38, 53, 83, 151, 173 |
| abstract_inverted_index.present | 23, 68, 139 |
| abstract_inverted_index.remains | 20 |
| abstract_inverted_index.results | 69, 140 |
| abstract_inverted_index.reverse | 41 |
| abstract_inverted_index.tissue, | 85 |
| abstract_inverted_index.various | 17 |
| abstract_inverted_index.western | 60 |
| abstract_inverted_index.accepted | 6 |
| abstract_inverted_index.adjacent | 77 |
| abstract_inverted_index.analysis | 62 |
| abstract_inverted_index.approach | 166 |
| abstract_inverted_index.assessed | 58 |
| abstract_inverted_index.compared | 80 |
| abstract_inverted_index.features | 36 |
| abstract_inverted_index.however, | 11 |
| abstract_inverted_index.negative | 119 |
| abstract_inverted_index.patients | 171 |
| abstract_inverted_index.presence | 93 |
| abstract_inverted_index.reaction | 45 |
| abstract_inverted_index.revealed | 70 |
| abstract_inverted_index.targeted | 155 |
| abstract_inverted_index.vascular | 125 |
| abstract_inverted_index.increased | 75 |
| abstract_inverted_index.migration | 65 |
| abstract_inverted_index.potential | 161 |
| abstract_inverted_index.regulator | 120 |
| abstract_inverted_index.suggested | 141 |
| abstract_inverted_index.transwell | 64 |
| abstract_inverted_index.treatment | 169 |
| abstract_inverted_index.Therefore, | 153 |
| abstract_inverted_index.correlated | 90 |
| abstract_inverted_index.expression | 13, 32, 73 |
| abstract_inverted_index.polymerase | 43 |
| abstract_inverted_index.regulation | 156 |
| abstract_inverted_index.suppressor | 149 |
| abstract_inverted_index.association | 29 |
| abstract_inverted_index.conclusion, | 137 |
| abstract_inverted_index.endothelial | 126 |
| abstract_inverted_index.experiments | 111 |
| abstract_inverted_index.hydroxylase | 1 |
| abstract_inverted_index.investigate | 27 |
| abstract_inverted_index.metastasis. | 108 |
| abstract_inverted_index.participate | 132 |
| abstract_inverted_index.suppressor; | 10 |
| abstract_inverted_index.therapeutic | 165 |
| abstract_inverted_index.demonstrated | 112 |
| abstract_inverted_index.factor‑1α | 123 |
| abstract_inverted_index.angiogenesis. | 135 |
| abstract_inverted_index.classification | 101 |
| abstract_inverted_index.controversial. | 21 |
| abstract_inverted_index.overexpression | 88 |
| abstract_inverted_index.non‑cancerous | 78 |
| abstract_inverted_index.clinicopathological | 35 |
| abstract_inverted_index.hypoxia‑inducible | 122 |
| abstract_inverted_index.immunohistochemistry. | 47 |
| abstract_inverted_index.well‑differentiated | 95 |
| abstract_inverted_index.transcription‑quantitative | 42 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6700000166893005 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.55865578 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |