Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes Article Swipe
Rachel A. Botting
,
Kirstie M. Bertram
,
Heeva Baharlou
,
Kerrie J. Sandgren
,
James Fletcher
,
Jake W. Rhodes
,
Hafsa Rana
,
T. Plasto
,
Xin Maggie Wang
,
Jake Lim
,
Laith Barnouti
,
Mark P. Kohout
,
T. Papadopoulos
,
Steve Merten
,
Norman A. Olbourne
,
Anthony L. Cunningham
,
Muzlifah Haniffa
,
Andrew N. Harman
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1189/jlb.4a1116-496r
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1189/jlb.4a1116-496r
Mononuclear phagocytes are present in skin and mucosa and represent one of the first lines of defense against invading pathogens, which they detect via an array of pathogen-binding receptors expressed on their surface. However, their extraction from tissue is difficult, and the isolation technique used has functional consequences on the cells obtained. Here, we compare mononuclear phagocytes isolated from human skin using either enzymatic digestion or spontaneous migration. Cells isolated via enzymatic digestion are in an immature state, and all subsets are easily defined. However, cells isolated by spontaneous migration are in a mature state, and CD141 cross-presenting DCs (cDC1) are more difficult to define. Different pathogen-binding receptors are susceptible to cleavage by blends of collagenase, demonstrating that great care must be taken in choosing the correct enzyme blend to digest tissue if carrying out pathogen-interaction assays. Finally, we have optimized mononuclear phagocyte culture conditions to enhance their survival after liberation from the tissue.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1189/jlb.4a1116-496r
- https://jlb.onlinelibrary.wiley.com/doi/pdfdirect/10.1189/jlb.4A1116-496R
- OA Status
- hybrid
- Cited By
- 49
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2592533921
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2592533921Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1189/jlb.4a1116-496rDigital Object Identifier
- Title
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Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-03-07Full publication date if available
- Authors
-
Rachel A. Botting, Kirstie M. Bertram, Heeva Baharlou, Kerrie J. Sandgren, James Fletcher, Jake W. Rhodes, Hafsa Rana, T. Plasto, Xin Maggie Wang, Jake Lim, Laith Barnouti, Mark P. Kohout, T. Papadopoulos, Steve Merten, Norman A. Olbourne, Anthony L. Cunningham, Muzlifah Haniffa, Andrew N. HarmanList of authors in order
- Landing page
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https://doi.org/10.1189/jlb.4a1116-496rPublisher landing page
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https://jlb.onlinelibrary.wiley.com/doi/pdfdirect/10.1189/jlb.4A1116-496RDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://jlb.onlinelibrary.wiley.com/doi/pdfdirect/10.1189/jlb.4A1116-496RDirect OA link when available
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Biology, Phenotype, Isolation (microbiology), Peripheral blood mononuclear cell, Immunology, Microbiology, Genetics, Gene, In vitroTop concepts (fields/topics) attached by OpenAlex
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49Total citation count in OpenAlex
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2025: 3, 2024: 2, 2023: 5, 2022: 9, 2021: 13Per-year citation counts (last 5 years)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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