Phenotyping nocturnal polyuria: circadian and age-related variations in diuresis rate, free water clearance and sodium clearance Article Swipe
Thomas F. Monaghan
,
Donald L. Bliwise
,
Marie‐Astrid Denys
,
An‐Sofie Goessaert
,
Veerle Decalf
,
Candy Kumps
,
Johan Vande Walle
,
Jeffrey P. Weiss
,
Matthew Epstein
,
Jeremy Weedon
,
Jason Lazar
,
Karel Everaert
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/ageing/afz200
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/ageing/afz200
Background this study compares diuresis rate, sodium clearance and free water clearance (FWC) by age and time of day (nighttime vs. daytime) in subjects with and without nocturnal polyuria (NP) to determine whether these variables affect the phenotype of NP. Methods post hoc analysis of two prospective observational studies. Eight urine samples collected at 3-h intervals and a single blood sample were used to calculate daytime (10a/1p/4p/7p/10p) and nighttime (1a/4a/7a) diuresis rates, sodium clearance and FWC. Three mixed linear models were constructed for diuresis rate, sodium clearance and FWC using four predictor variables: NP status (present [nocturnal urine production >90 ml/h] vs. absent [≤90 ml/h]), time of day, age and study identification. Results subjects with NP experienced higher nighttime versus daytime diuresis rates, sodium clearance and FWC. Regardless of NP status, increased age was accompanied by an increase in the ratio of nighttime/daytime diuresis rate, nighttime sodium clearance and daytime sodium clearance. FWC showed a complex age effect, which was independent of time of day or NP status. Conclusions age-related increases in nighttime/daytime diuresis rate, 24-h sodium clearance and 24-h FWC are not specific to subjects with NP. The age-related surge in either nocturnal sodium clearance or nocturnal FWC may represent the relevant substrate for behavioural or pharmacologic interventions targeting sodium diuresis or free water diuresis, respectively. Increases in FWC in older age groups may reflect impaired circadian rhythmicity of endogenous AVP or changes in responsiveness of the aged nephron to water clearance.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ageing/afz200
- https://academic.oup.com/ageing/article-pdf/49/3/439/33137813/afz200.pdf
- OA Status
- bronze
- Cited By
- 9
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3009977686
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3009977686Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ageing/afz200Digital Object Identifier
- Title
-
Phenotyping nocturnal polyuria: circadian and age-related variations in diuresis rate, free water clearance and sodium clearanceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Thomas F. Monaghan, Donald L. Bliwise, Marie‐Astrid Denys, An‐Sofie Goessaert, Veerle Decalf, Candy Kumps, Johan Vande Walle, Jeffrey P. Weiss, Matthew Epstein, Jeremy Weedon, Jason Lazar, Karel EveraertList of authors in order
- Landing page
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https://doi.org/10.1093/ageing/afz200Publisher landing page
- PDF URL
-
https://academic.oup.com/ageing/article-pdf/49/3/439/33137813/afz200.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/ageing/article-pdf/49/3/439/33137813/afz200.pdfDirect OA link when available
- Concepts
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Diuresis, Medicine, Endocrinology, Internal medicine, Natriuresis, Circadian rhythm, Sodium, Nocturnal, Free water clearance, Urine, Renal function, Chemistry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 3, 2022: 2, 2021: 2, 2020: 2Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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