Phrenic motor neuron loss in aged rats Article Swipe
Matthew J. Fogarty
,
Tanya S. Omar
,
Wen‐Zhi Zhan
,
Carlos B. Mantilla
,
Gary C. Sieck
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1152/jn.00868.2017
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1152/jn.00868.2017
Sarcopenia is the age-related reduction of muscle mass and specific force. In previous studies, we found that sarcopenia of the diaphragm muscle (DIAm) is evident by 24 mo of age in both rats and mice and is associated with selective atrophy of type IIx and IIb muscle fibers and a decrease in maximum specific force. These fiber type-specific effects of sarcopenia resemble those induced by DIAm denervation, leading us to hypothesize that sarcopenia is due to an age-related loss of phrenic motor neurons (PhMNs). To address this hypothesis, we determined the number of PhMNs in young (6 mo old) and old (24 mo old) Fischer 344 rats. Moreover, we determined age-related changes in the size of PhMNs, since larger PhMNs innervate type IIx and IIb DIAm fibers. The PhMN pool was retrogradely labeled and imaged with confocal microscopy to assess the number of PhMNs and the morphometry of PhMN soma and proximal dendrites. In older animals, there were 22% fewer PhMNs, a 19% decrease in somal surface area, and a 21% decrease in dendritic surface area compared with young Fischer 344 rats. The age-associated loss of PhMNs involved predominantly larger PhMNs. These results are consistent with an age-related denervation of larger, more fatigable DIAm motor units, which are required primarily for high-force airway clearance behaviors. NEW & NOTEWORTHY Diaphragm muscle sarcopenia in rodent models is well described in the literature; however, the relationship between sarcopenia and frank phrenic motor neuron (MN) loss is unexplored in these models. We quantify a 22% loss of phrenic MNs in old (24 mo) compared with young (6 mo) Fischer 344 rats. We also report reductions in phrenic MN somal and proximal dendritic morphology that relate to decreased MN heterogeneity in old compared with young Fischer 344 rats.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/jn.00868.2017
- https://www.physiology.org/doi/pdf/10.1152/jn.00868.2017
- OA Status
- bronze
- Cited By
- 72
- References
- 110
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2785337257
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- OpenAlex ID
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https://openalex.org/W2785337257Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1152/jn.00868.2017Digital Object Identifier
- Title
-
Phrenic motor neuron loss in aged ratsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-02-07Full publication date if available
- Authors
-
Matthew J. Fogarty, Tanya S. Omar, Wen‐Zhi Zhan, Carlos B. Mantilla, Gary C. SieckList of authors in order
- Landing page
-
https://doi.org/10.1152/jn.00868.2017Publisher landing page
- PDF URL
-
https://www.physiology.org/doi/pdf/10.1152/jn.00868.2017Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.physiology.org/doi/pdf/10.1152/jn.00868.2017Direct OA link when available
- Concepts
-
Sarcopenia, Denervation, Diaphragm muscle, Atrophy, Diaphragm (acoustics), Motor neuron, Internal medicine, Soma, Ageing, Anatomy, Endocrinology, Respiratory system, Chemistry, Neuroscience, Biology, Medicine, Spinal cord, Physics, Loudspeaker, AcousticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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72Total citation count in OpenAlex
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2025: 6, 2024: 5, 2023: 8, 2022: 11, 2021: 9Per-year citation counts (last 5 years)
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110Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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