pH.Responsive Polyion Complex (PIC) Vesicles Covered with Phosphorylcholine Groups.Containing Shells Article Swipe
pH–responsive polyion complex (PIC) vesicles were prepared, that collapse under acidic conditions such as those inside a lysosome. Furthermore, at acidic conditions, cationic polymer was released from the PIC vesicles to break the lysosome membranes. Diblock copolymers (P20M167 and P20A190) composed of a charge–neutralized water–soluble poly(2–(methacryloyloxy)ethyl phosphorylcholine) (PMPC; P) block and cationic or anionic blocks were synthesized via controlled radical polymerization. Poly(3–(methacrylamidopropyl)trimethylammonium chloride) (PMAPTAC; M) and poly(sodium 6–acrylamidohexanoate) (PAaH; A) were used as the cationic and anionic blocks, respectively. While the pendant fatty acid groups in the PAaH block are ionized in basic water, the fatty acid groups are protonated in acidic water. In basic water PIC vesicles were formed with a stoichiometrically charge neutralized mixture of oppositely charged P20M167 and P20A190. At acidic conditions, the PIC vesicles collapsed, because the charge balance shifted due to protonation of the PAaH block. After collapse of the PIC vesicles, P20A190 formed micelles, while P20M167 was released as unimers. PIC vesicles can encapsulate hydrophilic non–ionic guest molecules. At acidic conditions, the PIC vesicles can release the guest molecules and P20M167. The cationic P20M167 breaks the lysosome membrane to release the guest molecules from the lysosomes to the cytoplasm.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5360/membrane.47.147
- OA Status
- diamond
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285296629
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285296629Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5360/membrane.47.147Digital Object Identifier
- Title
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pH.Responsive Polyion Complex (PIC) Vesicles Covered with Phosphorylcholine Groups.Containing ShellsWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
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Shin‐ichi YusaList of authors in order
- Landing page
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https://doi.org/10.5360/membrane.47.147Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://doi.org/10.5360/membrane.47.147Direct OA link when available
- Concepts
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Cationic polymerization, Vesicle, Chemistry, Protonation, Membrane, Micelle, Polymer chemistry, Polymerization, Phosphorylcholine, Polymer, Organic chemistry, Aqueous solution, Biochemistry, IonTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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