Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation Article Swipe
Weixia Li
,
Liqiong Guo
,
Junkai Fang
,
Lei Zhao
,
Shanjun Song
,
Tao Fang
,
Chenguang Li
,
Lei Wang
,
Penghui Li
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fpubh.2023.1108555
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fpubh.2023.1108555
Background Phthalates (PAEs) are important synthetic substances in plastics, attracting much attention due to their potential effects on the cardiovascular system. Methods In this study, urine and blood samples from 39 individuals were collected in Tianjin, China. Phthalates and phthalate metabolites (mPAEs) were analyzed using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography-mass spectrometry (HPLC-MS), respectively. The polymerase chain reaction (PCR) products from bisulfite-treated mitochondrial DNA ( mtDNA ) samples were analyzed using pyrosequencing technology. Results The detection frequencies for 9 PAEs varied from 2.56 to 92.31%, and those for 10 mPAEs varied from 30.77 to 100%. The estimated daily intakes (EDIs) and cumulative risk of PAEs were calculated based on the experimental statistics of urinary PAEs and mPAEs. For PAEs, the HI RfD (hazard index corresponding to reference doses) values of 10.26% of participants and the HI TDI (hazard index corresponding to tolerable daily intake) values of 30.77% of participants were estimated to exceed 1, suggesting a relatively high exposure risk. The mtDNA methylation levels in the MT-ATP8 and MT-ND5 were observed to be lower than in the MT-ATP6 . Mono-ethyl phthalate (MEP) and MT-ATP8 were positively correlated with triglyceride levels ( p < 0.05). Based on the association of PAEs, mtDNA methylation, and triglycerides, the mediating role of mtDNA methylation between PAEs and cardiovascular diseases (CVDs) was analyzed in this study, but no mediated effect was observed. Conclusion The effects of PAE exposure on cardiovascular diseases (CVDs) should be investigated further.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fpubh.2023.1108555
- OA Status
- gold
- Cited By
- 6
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367054472
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4367054472Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fpubh.2023.1108555Digital Object Identifier
- Title
-
Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-26Full publication date if available
- Authors
-
Weixia Li, Liqiong Guo, Junkai Fang, Lei Zhao, Shanjun Song, Tao Fang, Chenguang Li, Lei Wang, Penghui LiList of authors in order
- Landing page
-
https://doi.org/10.3389/fpubh.2023.1108555Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fpubh.2023.1108555Direct OA link when available
- Concepts
-
Phthalate, Urine, Methylation, DNA methylation, Chemistry, Chromatography, Environmental chemistry, DNA, Biochemistry, Gene, Gene expression, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
55Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4367054472 |
|---|---|
| doi | https://doi.org/10.3389/fpubh.2023.1108555 |
| ids.doi | https://doi.org/10.3389/fpubh.2023.1108555 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37181721 |
| ids.openalex | https://openalex.org/W4367054472 |
| fwci | 1.4018569 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D004781 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Environmental Exposure |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D008745 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Methylation |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D004272 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | DNA, Mitochondrial |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D002318 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cardiovascular Diseases |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D010795 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Phthalic Acids |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D004781 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Environmental Exposure |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008745 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Methylation |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D004272 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | DNA, Mitochondrial |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D002318 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Cardiovascular Diseases |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D010795 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Phthalic Acids |
| type | article |
| title | Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation |
| biblio.issue | |
| biblio.volume | 11 |
| biblio.last_page | 1108555 |
| biblio.first_page | 1108555 |
| grants[0].funder | https://openalex.org/F4320321543 |
| grants[0].award_id | |
| grants[0].funder_display_name | China Postdoctoral Science Foundation |
| topics[0].id | https://openalex.org/T10686 |
| topics[0].field.id | https://openalex.org/fields/23 |
| topics[0].field.display_name | Environmental Science |
| topics[0].score | 0.9958000183105469 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2307 |
| topics[0].subfield.display_name | Health, Toxicology and Mutagenesis |
| topics[0].display_name | Effects and risks of endocrine disrupting chemicals |
| topics[1].id | https://openalex.org/T12267 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9926000237464905 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2737 |
| topics[1].subfield.display_name | Physiology |
| topics[1].display_name | Diet and metabolism studies |
| topics[2].id | https://openalex.org/T10836 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.967199981212616 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Metabolomics and Mass Spectrometry Studies |
| funders[0].id | https://openalex.org/F4320321543 |
| funders[0].ror | https://ror.org/0426zh255 |
| funders[0].display_name | China Postdoctoral Science Foundation |
| is_xpac | False |
| apc_list.value | 2490 |
| apc_list.currency | USD |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2490 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C2781005124 |
| concepts[0].level | 2 |
| concepts[0].score | 0.9376990795135498 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q84483575 |
| concepts[0].display_name | Phthalate |
| concepts[1].id | https://openalex.org/C2780026642 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7221059799194336 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q40924 |
| concepts[1].display_name | Urine |
| concepts[2].id | https://openalex.org/C33288867 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5749791264533997 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q518328 |
| concepts[2].display_name | Methylation |
| concepts[3].id | https://openalex.org/C190727270 |
| concepts[3].level | 4 |
| concepts[3].score | 0.516502320766449 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[3].display_name | DNA methylation |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.500978946685791 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C43617362 |
| concepts[5].level | 1 |
| concepts[5].score | 0.41249412298202515 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[5].display_name | Chromatography |
| concepts[6].id | https://openalex.org/C107872376 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3573160767555237 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q321355 |
| concepts[6].display_name | Environmental chemistry |
| concepts[7].id | https://openalex.org/C552990157 |
| concepts[7].level | 2 |
| concepts[7].score | 0.1736760139465332 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7430 |
| concepts[7].display_name | DNA |
| concepts[8].id | https://openalex.org/C55493867 |
| concepts[8].level | 1 |
| concepts[8].score | 0.1272098422050476 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[8].display_name | Biochemistry |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.06506437063217163 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| concepts[10].id | https://openalex.org/C150194340 |
| concepts[10].level | 3 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[10].display_name | Gene expression |
| concepts[11].id | https://openalex.org/C178790620 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[11].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/phthalate |
| keywords[0].score | 0.9376990795135498 |
| keywords[0].display_name | Phthalate |
| keywords[1].id | https://openalex.org/keywords/urine |
| keywords[1].score | 0.7221059799194336 |
| keywords[1].display_name | Urine |
| keywords[2].id | https://openalex.org/keywords/methylation |
| keywords[2].score | 0.5749791264533997 |
| keywords[2].display_name | Methylation |
| keywords[3].id | https://openalex.org/keywords/dna-methylation |
| keywords[3].score | 0.516502320766449 |
| keywords[3].display_name | DNA methylation |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.500978946685791 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/chromatography |
| keywords[5].score | 0.41249412298202515 |
| keywords[5].display_name | Chromatography |
| keywords[6].id | https://openalex.org/keywords/environmental-chemistry |
| keywords[6].score | 0.3573160767555237 |
| keywords[6].display_name | Environmental chemistry |
| keywords[7].id | https://openalex.org/keywords/dna |
| keywords[7].score | 0.1736760139465332 |
| keywords[7].display_name | DNA |
| keywords[8].id | https://openalex.org/keywords/biochemistry |
| keywords[8].score | 0.1272098422050476 |
| keywords[8].display_name | Biochemistry |
| keywords[9].id | https://openalex.org/keywords/gene |
| keywords[9].score | 0.06506437063217163 |
| keywords[9].display_name | Gene |
| language | en |
| locations[0].id | doi:10.3389/fpubh.2023.1108555 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2595931848 |
| locations[0].source.issn | 2296-2565 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2296-2565 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Public Health |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Public Health |
| locations[0].landing_page_url | https://doi.org/10.3389/fpubh.2023.1108555 |
| locations[1].id | pmid:37181721 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in public health |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37181721 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10169620 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10169620/pdf/fpubh-11-1108555.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Front Public Health |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10169620 |
| locations[3].id | pmh:oai:doaj.org/article:3aad0139a34a45019dc9cc8d44d7b191 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Frontiers in Public Health, Vol 11 (2023) |
| locations[3].landing_page_url | https://doaj.org/article/3aad0139a34a45019dc9cc8d44d7b191 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5107901835 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5945-6350 |
| authorships[0].author.display_name | Weixia Li |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210119864 |
| authorships[0].affiliations[0].raw_affiliation_string | Tianjin Fourth Central Hospital, Tianjin, China |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I136765683 |
| authorships[0].affiliations[1].raw_affiliation_string | School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China |
| authorships[0].affiliations[2].raw_affiliation_string | Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, China |
| authorships[0].institutions[0].id | https://openalex.org/I4210119864 |
| authorships[0].institutions[0].ror | https://ror.org/02m9tqe79 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210119864 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Tianjin Fourth Central Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I136765683 |
| authorships[0].institutions[1].ror | https://ror.org/00zbe0w13 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I136765683 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Tianjin University of Technology |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Weixia Li |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China, Tianjin Fourth Central Hospital, Tianjin, China, Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, China |
| authorships[1].author.id | https://openalex.org/A5058471517 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-1141-9646 |
| authorships[1].author.display_name | Liqiong Guo |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210119864 |
| authorships[1].affiliations[0].raw_affiliation_string | Tianjin Fourth Central Hospital, Tianjin, China |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I162868743 |
| authorships[1].affiliations[1].raw_affiliation_string | Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin University, Tianjin, China |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I146620803, https://openalex.org/I162868743 |
| authorships[1].affiliations[2].raw_affiliation_string | Wenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, China |
| authorships[1].affiliations[3].institution_ids | https://openalex.org/I162868743 |
| authorships[1].affiliations[3].raw_affiliation_string | Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China |
| authorships[1].institutions[0].id | https://openalex.org/I4210119864 |
| authorships[1].institutions[0].ror | https://ror.org/02m9tqe79 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210119864 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Tianjin Fourth Central Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I162868743 |
| authorships[1].institutions[1].ror | https://ror.org/012tb2g32 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I162868743 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Tianjin University |
| authorships[1].institutions[2].id | https://openalex.org/I146620803 |
| authorships[1].institutions[2].ror | https://ror.org/020hxh324 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I146620803 |
| authorships[1].institutions[2].country_code | CN |
| authorships[1].institutions[2].display_name | Wenzhou University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Liqiong Guo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China, Tianjin Fourth Central Hospital, Tianjin, China, Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin University, Tianjin, China, Wenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, China |
| authorships[2].author.id | https://openalex.org/A5070946654 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Junkai Fang |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210105139 |
| authorships[2].affiliations[0].raw_affiliation_string | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin, China |
| authorships[2].institutions[0].id | https://openalex.org/I4210105139 |
| authorships[2].institutions[0].ror | https://ror.org/01g9y2x13 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210105139 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Tianjin Institute of Pharmaceutical Research (China) |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Junkai Fang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin, China |
| authorships[3].author.id | https://openalex.org/A5008914329 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8718-7709 |
| authorships[3].author.display_name | Lei Zhao |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I162868743 |
| authorships[3].affiliations[0].raw_affiliation_string | Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin University, Tianjin, China |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I162868743 |
| authorships[3].affiliations[1].raw_affiliation_string | Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I146620803, https://openalex.org/I162868743 |
| authorships[3].affiliations[2].raw_affiliation_string | Wenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, China |
| authorships[3].institutions[0].id | https://openalex.org/I162868743 |
| authorships[3].institutions[0].ror | https://ror.org/012tb2g32 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I162868743 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Tianjin University |
| authorships[3].institutions[1].id | https://openalex.org/I146620803 |
| authorships[3].institutions[1].ror | https://ror.org/020hxh324 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I146620803 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Wenzhou University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Lei Zhao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China, Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin University, Tianjin, China, Wenzhou Safety (Emergency) Institute, Tianjin University, Wenzhou, China |
| authorships[4].author.id | https://openalex.org/A5085973318 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4125-5179 |
| authorships[4].author.display_name | Shanjun Song |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210162136 |
| authorships[4].affiliations[0].raw_affiliation_string | National Institute of Metrology, Beijing, China |
| authorships[4].institutions[0].id | https://openalex.org/I4210162136 |
| authorships[4].institutions[0].ror | https://ror.org/05dw0p167 |
| authorships[4].institutions[0].type | other |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210162136 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | National Institute of Metrology |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Shanjun Song |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | National Institute of Metrology, Beijing, China |
| authorships[5].author.id | https://openalex.org/A5069150810 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Tao Fang |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210119864 |
| authorships[5].affiliations[0].raw_affiliation_string | Tianjin Fourth Central Hospital, Tianjin, China |
| authorships[5].institutions[0].id | https://openalex.org/I4210119864 |
| authorships[5].institutions[0].ror | https://ror.org/02m9tqe79 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210119864 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Tianjin Fourth Central Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Tao Fang |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Tianjin Fourth Central Hospital, Tianjin, China |
| authorships[6].author.id | https://openalex.org/A5100783273 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4058-2901 |
| authorships[6].author.display_name | Chenguang Li |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I136765683 |
| authorships[6].affiliations[0].raw_affiliation_string | School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China |
| authorships[6].affiliations[1].raw_affiliation_string | Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, China |
| authorships[6].institutions[0].id | https://openalex.org/I136765683 |
| authorships[6].institutions[0].ror | https://ror.org/00zbe0w13 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I136765683 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Tianjin University of Technology |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Chenguang Li |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China, Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, China |
| authorships[7].author.id | https://openalex.org/A5100436021 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8193-9954 |
| authorships[7].author.display_name | Lei Wang |
| authorships[7].affiliations[0].raw_affiliation_string | Hebei Research Center for Geoanalysis, Baoding, Hebei, China |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Lei Wang |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Hebei Research Center for Geoanalysis, Baoding, Hebei, China |
| authorships[8].author.id | https://openalex.org/A5100781840 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7960-1025 |
| authorships[8].author.display_name | Penghui Li |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].raw_affiliation_string | Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, China |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210119864 |
| authorships[8].affiliations[1].raw_affiliation_string | Tianjin Fourth Central Hospital, Tianjin, China |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I136765683 |
| authorships[8].affiliations[2].raw_affiliation_string | School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China |
| authorships[8].institutions[0].id | https://openalex.org/I4210119864 |
| authorships[8].institutions[0].ror | https://ror.org/02m9tqe79 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210119864 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Tianjin Fourth Central Hospital |
| authorships[8].institutions[1].id | https://openalex.org/I136765683 |
| authorships[8].institutions[1].ror | https://ror.org/00zbe0w13 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I136765683 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Tianjin University of Technology |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Penghui Li |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, China, Tianjin Fourth Central Hospital, Tianjin, China, Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, China |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/fpubh.2023.1108555 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10686 |
| primary_topic.field.id | https://openalex.org/fields/23 |
| primary_topic.field.display_name | Environmental Science |
| primary_topic.score | 0.9958000183105469 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2307 |
| primary_topic.subfield.display_name | Health, Toxicology and Mutagenesis |
| primary_topic.display_name | Effects and risks of endocrine disrupting chemicals |
| related_works | https://openalex.org/W2601959191, https://openalex.org/W2902329290, https://openalex.org/W2052355316, https://openalex.org/W2128056428, https://openalex.org/W2046964473, https://openalex.org/W2107880877, https://openalex.org/W2151182744, https://openalex.org/W2024490794, https://openalex.org/W1998349112, https://openalex.org/W2054863651 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fpubh.2023.1108555 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2595931848 |
| best_oa_location.source.issn | 2296-2565 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2296-2565 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Public Health |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Public Health |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fpubh.2023.1108555 |
| primary_location.id | doi:10.3389/fpubh.2023.1108555 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2595931848 |
| primary_location.source.issn | 2296-2565 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2296-2565 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Public Health |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Public Health |
| primary_location.landing_page_url | https://doi.org/10.3389/fpubh.2023.1108555 |
| publication_date | 2023-04-26 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2980974193, https://openalex.org/W3175115288, https://openalex.org/W2806058276, https://openalex.org/W1995847948, https://openalex.org/W2037511493, https://openalex.org/W2947820956, https://openalex.org/W2056768052, https://openalex.org/W2912614840, https://openalex.org/W3004294111, https://openalex.org/W1980615604, https://openalex.org/W2104744942, https://openalex.org/W3205015862, https://openalex.org/W2953014037, https://openalex.org/W3015335149, https://openalex.org/W3186130386, https://openalex.org/W2732477977, https://openalex.org/W4285810185, https://openalex.org/W3122226502, https://openalex.org/W4281978099, https://openalex.org/W3157315627, https://openalex.org/W2907241880, https://openalex.org/W1853227327, https://openalex.org/W2906229866, https://openalex.org/W3012975132, https://openalex.org/W2776177791, https://openalex.org/W4206445246, https://openalex.org/W1828742533, https://openalex.org/W2750992680, https://openalex.org/W3157191180, https://openalex.org/W2589101092, https://openalex.org/W2894054447, https://openalex.org/W2899711892, https://openalex.org/W2902234135, https://openalex.org/W2906982327, https://openalex.org/W4283589119, https://openalex.org/W1988772913, https://openalex.org/W2076216407, https://openalex.org/W2888438269, https://openalex.org/W2318413400, https://openalex.org/W2599042773, https://openalex.org/W2987094057, https://openalex.org/W3041344852, https://openalex.org/W2797886128, https://openalex.org/W3100212526, https://openalex.org/W3206634020, https://openalex.org/W1942061144, https://openalex.org/W2088501367, https://openalex.org/W3016664937, https://openalex.org/W2097127734, https://openalex.org/W2041966702, https://openalex.org/W3132461879, https://openalex.org/W2009970082, https://openalex.org/W1994612860, https://openalex.org/W2147713812, https://openalex.org/W2154393005 |
| referenced_works_count | 55 |
| abstract_inverted_index.( | 66, 192 |
| abstract_inverted_index.) | 68 |
| abstract_inverted_index.. | 180 |
| abstract_inverted_index.9 | 80 |
| abstract_inverted_index.a | 157 |
| abstract_inverted_index.p | 193 |
| abstract_inverted_index.1, | 155 |
| abstract_inverted_index.10 | 90 |
| abstract_inverted_index.39 | 30 |
| abstract_inverted_index.HI | 122, 137 |
| abstract_inverted_index.In | 22 |
| abstract_inverted_index.be | 174, 240 |
| abstract_inverted_index.in | 7, 34, 166, 177, 220 |
| abstract_inverted_index.no | 224 |
| abstract_inverted_index.of | 105, 114, 131, 133, 147, 149, 200, 209, 232 |
| abstract_inverted_index.on | 17, 110, 197, 235 |
| abstract_inverted_index.to | 13, 85, 95, 127, 142, 153, 173 |
| abstract_inverted_index.DNA | 65 |
| abstract_inverted_index.For | 119 |
| abstract_inverted_index.PAE | 233 |
| abstract_inverted_index.RfD | 123 |
| abstract_inverted_index.TDI | 138 |
| abstract_inverted_index.The | 56, 76, 97, 162, 230 |
| abstract_inverted_index.and | 26, 38, 49, 87, 102, 117, 135, 169, 184, 204, 214 |
| abstract_inverted_index.are | 3 |
| abstract_inverted_index.but | 223 |
| abstract_inverted_index.due | 12 |
| abstract_inverted_index.for | 79, 89 |
| abstract_inverted_index.gas | 45 |
| abstract_inverted_index.the | 18, 111, 121, 136, 167, 178, 198, 206 |
| abstract_inverted_index.was | 218, 227 |
| abstract_inverted_index.2.56 | 84 |
| abstract_inverted_index.PAEs | 81, 106, 116, 213 |
| abstract_inverted_index.from | 29, 62, 83, 93 |
| abstract_inverted_index.high | 159 |
| abstract_inverted_index.much | 10 |
| abstract_inverted_index.risk | 104 |
| abstract_inverted_index.role | 208 |
| abstract_inverted_index.than | 176 |
| abstract_inverted_index.this | 23, 221 |
| abstract_inverted_index.were | 32, 42, 70, 107, 151, 171, 186 |
| abstract_inverted_index.with | 189 |
| abstract_inverted_index.(MEP) | 183 |
| abstract_inverted_index.(PCR) | 60 |
| abstract_inverted_index.100%. | 96 |
| abstract_inverted_index.30.77 | 94 |
| abstract_inverted_index.Based | 196 |
| abstract_inverted_index.PAEs, | 120, 201 |
| abstract_inverted_index.based | 109 |
| abstract_inverted_index.blood | 27 |
| abstract_inverted_index.chain | 58 |
| abstract_inverted_index.daily | 99, 144 |
| abstract_inverted_index.index | 125, 140 |
| abstract_inverted_index.lower | 175 |
| abstract_inverted_index.mPAEs | 91 |
| abstract_inverted_index.mtDNA | 67, 163, 202, 210 |
| abstract_inverted_index.risk. | 161 |
| abstract_inverted_index.their | 14 |
| abstract_inverted_index.those | 88 |
| abstract_inverted_index.urine | 25 |
| abstract_inverted_index.using | 44, 72 |
| abstract_inverted_index.(CVDs) | 217, 238 |
| abstract_inverted_index.(EDIs) | 101 |
| abstract_inverted_index.(PAEs) | 2 |
| abstract_inverted_index.0.05). | 195 |
| abstract_inverted_index.10.26% | 132 |
| abstract_inverted_index.30.77% | 148 |
| abstract_inverted_index.China. | 36 |
| abstract_inverted_index.MT-ND5 | 170 |
| abstract_inverted_index.doses) | 129 |
| abstract_inverted_index.effect | 226 |
| abstract_inverted_index.exceed | 154 |
| abstract_inverted_index.levels | 165, 191 |
| abstract_inverted_index.liquid | 51 |
| abstract_inverted_index.mPAEs. | 118 |
| abstract_inverted_index.should | 239 |
| abstract_inverted_index.study, | 24, 222 |
| abstract_inverted_index.values | 130, 146 |
| abstract_inverted_index.varied | 82, 92 |
| abstract_inverted_index.(GC-MS) | 48 |
| abstract_inverted_index.(hazard | 124, 139 |
| abstract_inverted_index.(mPAEs) | 41 |
| abstract_inverted_index.92.31%, | 86 |
| abstract_inverted_index.MT-ATP6 | 179 |
| abstract_inverted_index.MT-ATP8 | 168, 185 |
| abstract_inverted_index.Methods | 21 |
| abstract_inverted_index.Results | 75 |
| abstract_inverted_index.between | 212 |
| abstract_inverted_index.effects | 16, 231 |
| abstract_inverted_index.intake) | 145 |
| abstract_inverted_index.intakes | 100 |
| abstract_inverted_index.samples | 28, 69 |
| abstract_inverted_index.system. | 20 |
| abstract_inverted_index.urinary | 115 |
| abstract_inverted_index.&lt; | 194 |
| abstract_inverted_index.Tianjin, | 35 |
| abstract_inverted_index.analyzed | 43, 71, 219 |
| abstract_inverted_index.diseases | 216, 237 |
| abstract_inverted_index.exposure | 160, 234 |
| abstract_inverted_index.further. | 242 |
| abstract_inverted_index.mediated | 225 |
| abstract_inverted_index.observed | 172 |
| abstract_inverted_index.products | 61 |
| abstract_inverted_index.reaction | 59 |
| abstract_inverted_index.attention | 11 |
| abstract_inverted_index.collected | 33 |
| abstract_inverted_index.detection | 77 |
| abstract_inverted_index.estimated | 98, 152 |
| abstract_inverted_index.important | 4 |
| abstract_inverted_index.mediating | 207 |
| abstract_inverted_index.observed. | 228 |
| abstract_inverted_index.phthalate | 39, 182 |
| abstract_inverted_index.plastics, | 8 |
| abstract_inverted_index.potential | 15 |
| abstract_inverted_index.reference | 128 |
| abstract_inverted_index.synthetic | 5 |
| abstract_inverted_index.tolerable | 143 |
| abstract_inverted_index.(HPLC-MS), | 54 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 229 |
| abstract_inverted_index.Mono-ethyl | 181 |
| abstract_inverted_index.Phthalates | 1, 37 |
| abstract_inverted_index.attracting | 9 |
| abstract_inverted_index.calculated | 108 |
| abstract_inverted_index.correlated | 188 |
| abstract_inverted_index.cumulative | 103 |
| abstract_inverted_index.polymerase | 57 |
| abstract_inverted_index.positively | 187 |
| abstract_inverted_index.relatively | 158 |
| abstract_inverted_index.statistics | 113 |
| abstract_inverted_index.substances | 6 |
| abstract_inverted_index.suggesting | 156 |
| abstract_inverted_index.association | 199 |
| abstract_inverted_index.frequencies | 78 |
| abstract_inverted_index.individuals | 31 |
| abstract_inverted_index.metabolites | 40 |
| abstract_inverted_index.methylation | 164, 211 |
| abstract_inverted_index.technology. | 74 |
| abstract_inverted_index.experimental | 112 |
| abstract_inverted_index.investigated | 241 |
| abstract_inverted_index.methylation, | 203 |
| abstract_inverted_index.participants | 134, 150 |
| abstract_inverted_index.spectrometry | 47, 53 |
| abstract_inverted_index.triglyceride | 190 |
| abstract_inverted_index.corresponding | 126, 141 |
| abstract_inverted_index.mitochondrial | 64 |
| abstract_inverted_index.respectively. | 55 |
| abstract_inverted_index.cardiovascular | 19, 215, 236 |
| abstract_inverted_index.pyrosequencing | 73 |
| abstract_inverted_index.triglycerides, | 205 |
| abstract_inverted_index.high-performance | 50 |
| abstract_inverted_index.bisulfite-treated | 63 |
| abstract_inverted_index.chromatography-mass | 46, 52 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5100436021, https://openalex.org/A5100781840 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I136765683, https://openalex.org/I4210119864 |
| citation_normalized_percentile.value | 0.73803067 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |