Physician approval for pregnancy in patients with SLE showing only serological activity: A vignette survey study Article Swipe
Sakiko Isojima
,
Nobuyuki Yajima
,
Ryo Yanai
,
Yoko Miura
,
Shingo Fukuma
,
Kayoko Kaneko
,
Keishi Fujio
,
Kenji Oku
,
Masakazu Matsushita
,
Takako Miyamae
,
Takashi Wada
,
Yoshiya Tanaka
,
Yuko Kaneko
,
Ayako Nakajima
,
Atsuko Murashima
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2049133/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2049133/v1
Background: The EULAR recommendation requires that the disease activity of systemic lupus erythematosus before pregnancy be stable because pregnancy complications and disease flares increase if pregnancy occurs while systemic lupus erythematosus activity is high. However, some patients have ongoing serological activity even after treatment. Herein, we aimed to investigate how physicians make decisions on the acceptability of pregnancy when patients with systemic lupus erythematosus only have serological activity. Methods: A questionnaire was administered online to physicians from December 2020 to January 2021. It included the characteristics of physicians, facilities, and the allowance for pregnancies for patients with systemic lupus erythematosus using vignette scenarios. Results: The questionnaire was distributed to 4,946 physicians, and 9.4% of physicians responded. The median age of respondents was 46 (range: 38–54) years, and 85% were rheumatologists. Pregnancy allowance was significantly affected by duration of the stable period, and mild or high serological activity, respectively (duration: proportion difference, 11.8 percentage points [p.p.]; p < 0.001; mild: proportion difference, -25.8 p.p; p < 0.001; high: -65.6 p.p.; p < 0.001). Even though patients had a high level of serological activity, 20.5% of physicians allowed pregnancy if there were no clinical symptoms for six months. Conclusions: Serological activity had a significant effect on physician judgment on the acceptability of pregnancy. Conversely, some physicians allowed patients who only had serological activity to become pregnant. Further observational studies are required to clarify the prognosis of such patients.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2049133/v1
- https://www.researchsquare.com/article/rs-2049133/latest.pdf
- OA Status
- green
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4297914233
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4297914233Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-2049133/v1Digital Object Identifier
- Title
-
Physician approval for pregnancy in patients with SLE showing only serological activity: A vignette survey studyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-15Full publication date if available
- Authors
-
Sakiko Isojima, Nobuyuki Yajima, Ryo Yanai, Yoko Miura, Shingo Fukuma, Kayoko Kaneko, Keishi Fujio, Kenji Oku, Masakazu Matsushita, Takako Miyamae, Takashi Wada, Yoshiya Tanaka, Yuko Kaneko, Ayako Nakajima, Atsuko MurashimaList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2049133/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-2049133/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-2049133/latest.pdfDirect OA link when available
- Concepts
-
Medicine, Serology, Pregnancy, Vignette, Observational study, Disease, Internal medicine, Obstetrics, Systemic lupus erythematosus, Pediatrics, Immunology, Antibody, Biology, Genetics, Social psychology, PsychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4297914233 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-2049133/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-2049133/v1 |
| ids.openalex | https://openalex.org/W4297914233 |
| fwci | 0.0 |
| type | preprint |
| title | Physician approval for pregnancy in patients with SLE showing only serological activity: A vignette survey study |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10308 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2745 |
| topics[0].subfield.display_name | Rheumatology |
| topics[0].display_name | Systemic Lupus Erythematosus Research |
| topics[1].id | https://openalex.org/T11964 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9983000159263611 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2739 |
| topics[1].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[1].display_name | Pregnancy and Medication Impact |
| topics[2].id | https://openalex.org/T11510 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9833999872207642 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Reproductive System and Pregnancy |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8700730204582214 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C45189115 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8616467714309692 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q502159 |
| concepts[1].display_name | Serology |
| concepts[2].id | https://openalex.org/C2779234561 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7885329127311707 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11995 |
| concepts[2].display_name | Pregnancy |
| concepts[3].id | https://openalex.org/C9719361 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5321152806282043 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7928967 |
| concepts[3].display_name | Vignette |
| concepts[4].id | https://openalex.org/C23131810 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4811204969882965 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q818574 |
| concepts[4].display_name | Observational study |
| concepts[5].id | https://openalex.org/C2779134260 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4761864244937897 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[5].display_name | Disease |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.45663976669311523 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C131872663 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4364510476589203 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q5284418 |
| concepts[7].display_name | Obstetrics |
| concepts[8].id | https://openalex.org/C2776912625 |
| concepts[8].level | 3 |
| concepts[8].score | 0.42943522334098816 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1485 |
| concepts[8].display_name | Systemic lupus erythematosus |
| concepts[9].id | https://openalex.org/C187212893 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3475918173789978 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q123028 |
| concepts[9].display_name | Pediatrics |
| concepts[10].id | https://openalex.org/C203014093 |
| concepts[10].level | 1 |
| concepts[10].score | 0.25700312852859497 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[10].display_name | Immunology |
| concepts[11].id | https://openalex.org/C159654299 |
| concepts[11].level | 2 |
| concepts[11].score | 0.19998139142990112 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q79460 |
| concepts[11].display_name | Antibody |
| concepts[12].id | https://openalex.org/C86803240 |
| concepts[12].level | 0 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[12].display_name | Biology |
| concepts[13].id | https://openalex.org/C54355233 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[13].display_name | Genetics |
| concepts[14].id | https://openalex.org/C77805123 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q161272 |
| concepts[14].display_name | Social psychology |
| concepts[15].id | https://openalex.org/C15744967 |
| concepts[15].level | 0 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[15].display_name | Psychology |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8700730204582214 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/serology |
| keywords[1].score | 0.8616467714309692 |
| keywords[1].display_name | Serology |
| keywords[2].id | https://openalex.org/keywords/pregnancy |
| keywords[2].score | 0.7885329127311707 |
| keywords[2].display_name | Pregnancy |
| keywords[3].id | https://openalex.org/keywords/vignette |
| keywords[3].score | 0.5321152806282043 |
| keywords[3].display_name | Vignette |
| keywords[4].id | https://openalex.org/keywords/observational-study |
| keywords[4].score | 0.4811204969882965 |
| keywords[4].display_name | Observational study |
| keywords[5].id | https://openalex.org/keywords/disease |
| keywords[5].score | 0.4761864244937897 |
| keywords[5].display_name | Disease |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.45663976669311523 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/obstetrics |
| keywords[7].score | 0.4364510476589203 |
| keywords[7].display_name | Obstetrics |
| keywords[8].id | https://openalex.org/keywords/systemic-lupus-erythematosus |
| keywords[8].score | 0.42943522334098816 |
| keywords[8].display_name | Systemic lupus erythematosus |
| keywords[9].id | https://openalex.org/keywords/pediatrics |
| keywords[9].score | 0.3475918173789978 |
| keywords[9].display_name | Pediatrics |
| keywords[10].id | https://openalex.org/keywords/immunology |
| keywords[10].score | 0.25700312852859497 |
| keywords[10].display_name | Immunology |
| keywords[11].id | https://openalex.org/keywords/antibody |
| keywords[11].score | 0.19998139142990112 |
| keywords[11].display_name | Antibody |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-2049133/v1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402450 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Research Square (Research Square) |
| locations[0].source.host_organization | https://openalex.org/I4210096694 |
| locations[0].source.host_organization_name | Research Square (United States) |
| locations[0].source.host_organization_lineage | https://openalex.org/I4210096694 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-2049133/latest.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-2049133/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5051013445 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7910-4774 |
| authorships[0].author.display_name | Sakiko Isojima |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I119182057 |
| authorships[0].affiliations[0].raw_affiliation_string | Showa University School of Medicine |
| authorships[0].institutions[0].id | https://openalex.org/I119182057 |
| authorships[0].institutions[0].ror | https://ror.org/04mzk4q39 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I119182057 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Showa University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Sakiko Isojima |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Showa University School of Medicine |
| authorships[1].author.id | https://openalex.org/A5073973778 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-8292-3962 |
| authorships[1].author.display_name | Nobuyuki Yajima |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I119182057 |
| authorships[1].affiliations[0].raw_affiliation_string | Showa University School of Medicine |
| authorships[1].institutions[0].id | https://openalex.org/I119182057 |
| authorships[1].institutions[0].ror | https://ror.org/04mzk4q39 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I119182057 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Showa University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Nobuyuki Yajima |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Showa University School of Medicine |
| authorships[2].author.id | https://openalex.org/A5084612102 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3118-7675 |
| authorships[2].author.display_name | Ryo Yanai |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I119182057 |
| authorships[2].affiliations[0].raw_affiliation_string | Showa University School of Medicine |
| authorships[2].institutions[0].id | https://openalex.org/I119182057 |
| authorships[2].institutions[0].ror | https://ror.org/04mzk4q39 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I119182057 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Showa University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ryo Yanai |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Showa University School of Medicine |
| authorships[3].author.id | https://openalex.org/A5102243158 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Yoko Miura |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I119182057 |
| authorships[3].affiliations[0].raw_affiliation_string | Showa University School of Medicine |
| authorships[3].institutions[0].id | https://openalex.org/I119182057 |
| authorships[3].institutions[0].ror | https://ror.org/04mzk4q39 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I119182057 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Showa University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yoko Miura |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Showa University School of Medicine |
| authorships[4].author.id | https://openalex.org/A5057534039 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8379-8761 |
| authorships[4].author.display_name | Shingo Fukuma |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I22299242 |
| authorships[4].affiliations[0].raw_affiliation_string | Kyoto University Graduate School of Medicine and Public Health |
| authorships[4].institutions[0].id | https://openalex.org/I22299242 |
| authorships[4].institutions[0].ror | https://ror.org/02kpeqv85 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I22299242 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Kyoto University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Shingo Fukuma |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Kyoto University Graduate School of Medicine and Public Health |
| authorships[5].author.id | https://openalex.org/A5052940212 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3411-5896 |
| authorships[5].author.display_name | Kayoko Kaneko |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210132193 |
| authorships[5].affiliations[0].raw_affiliation_string | National Center for Child Health and Development |
| authorships[5].institutions[0].id | https://openalex.org/I4210132193 |
| authorships[5].institutions[0].ror | https://ror.org/03fvwxc59 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210132193 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | National Center For Child Health and Development |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Kayoko Kaneko |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | National Center for Child Health and Development |
| authorships[6].author.id | https://openalex.org/A5070397387 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-7276-5254 |
| authorships[6].author.display_name | Keishi Fujio |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I74801974 |
| authorships[6].affiliations[0].raw_affiliation_string | The University of Tokyo |
| authorships[6].institutions[0].id | https://openalex.org/I74801974 |
| authorships[6].institutions[0].ror | https://ror.org/057zh3y96 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I74801974 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | The University of Tokyo |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Keishi Fujio |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | The University of Tokyo |
| authorships[7].author.id | https://openalex.org/A5061443644 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-0790-665X |
| authorships[7].author.display_name | Kenji Oku |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I64189623 |
| authorships[7].affiliations[0].raw_affiliation_string | Kitasato University |
| authorships[7].institutions[0].id | https://openalex.org/I64189623 |
| authorships[7].institutions[0].ror | https://ror.org/00f2txz25 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I64189623 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Kitasato University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Kenji Oku |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Kitasato University |
| authorships[8].author.id | https://openalex.org/A5014930296 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-3058-5778 |
| authorships[8].author.display_name | Masakazu Matsushita |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I34077901 |
| authorships[8].affiliations[0].raw_affiliation_string | Juntendo University School of Medicine |
| authorships[8].institutions[0].id | https://openalex.org/I34077901 |
| authorships[8].institutions[0].ror | https://ror.org/01692sz90 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I34077901 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | Juntendo University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Masakazu Matsushita |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Juntendo University School of Medicine |
| authorships[9].author.id | https://openalex.org/A5022049181 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-0568-1496 |
| authorships[9].author.display_name | Takako Miyamae |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210136522 |
| authorships[9].affiliations[0].raw_affiliation_string | Tokyo Women’s Medical University School of Medicine |
| authorships[9].institutions[0].id | https://openalex.org/I4210136522 |
| authorships[9].institutions[0].ror | https://ror.org/03kjjhe36 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210136522 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Tokyo Women's Medical University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Takako Miyamae |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Tokyo Women’s Medical University School of Medicine |
| authorships[10].author.id | https://openalex.org/A5057566812 |
| authorships[10].author.orcid | https://orcid.org/0009-0006-1586-7530 |
| authorships[10].author.display_name | Takashi Wada |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I10091056 |
| authorships[10].affiliations[0].raw_affiliation_string | Kanazawa University |
| authorships[10].institutions[0].id | https://openalex.org/I10091056 |
| authorships[10].institutions[0].ror | https://ror.org/02hwp6a56 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I10091056 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | Kanazawa University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Takashi Wada |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Kanazawa University |
| authorships[11].author.id | https://openalex.org/A5015953107 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0807-7139 |
| authorships[11].author.display_name | Yoshiya Tanaka |
| authorships[11].countries | JP |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I188700360 |
| authorships[11].affiliations[0].raw_affiliation_string | University of Occupational and Environmental Health |
| authorships[11].institutions[0].id | https://openalex.org/I188700360 |
| authorships[11].institutions[0].ror | https://ror.org/020p3h829 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I188700360 |
| authorships[11].institutions[0].country_code | JP |
| authorships[11].institutions[0].display_name | University of Occupational and Environmental Health Japan |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Yoshiya Tanaka |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | University of Occupational and Environmental Health |
| authorships[12].author.id | https://openalex.org/A5039165431 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-2646-5765 |
| authorships[12].author.display_name | Yuko Kaneko |
| authorships[12].countries | JP |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I203951103 |
| authorships[12].affiliations[0].raw_affiliation_string | Keio University School of Medicine |
| authorships[12].institutions[0].id | https://openalex.org/I203951103 |
| authorships[12].institutions[0].ror | https://ror.org/02kn6nx58 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I203951103 |
| authorships[12].institutions[0].country_code | JP |
| authorships[12].institutions[0].display_name | Keio University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Yuko Kaneko |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Keio University School of Medicine |
| authorships[13].author.id | https://openalex.org/A5102819401 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-6789-1739 |
| authorships[13].author.display_name | Ayako Nakajima |
| authorships[13].countries | JP |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210116542 |
| authorships[13].affiliations[0].raw_affiliation_string | Mie University Hospital |
| authorships[13].institutions[0].id | https://openalex.org/I4210116542 |
| authorships[13].institutions[0].ror | https://ror.org/01v9g9c07 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210116542 |
| authorships[13].institutions[0].country_code | JP |
| authorships[13].institutions[0].display_name | Mie University Hospital |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Ayako Nakajima |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Mie University Hospital |
| authorships[14].author.id | https://openalex.org/A5003153211 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-0569-7172 |
| authorships[14].author.display_name | Atsuko Murashima |
| authorships[14].countries | JP |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210132193 |
| authorships[14].affiliations[0].raw_affiliation_string | National Center for Child Health and Development |
| authorships[14].institutions[0].id | https://openalex.org/I4210132193 |
| authorships[14].institutions[0].ror | https://ror.org/03fvwxc59 |
| authorships[14].institutions[0].type | government |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210132193 |
| authorships[14].institutions[0].country_code | JP |
| authorships[14].institutions[0].display_name | National Center For Child Health and Development |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Atsuko Murashima |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | National Center for Child Health and Development |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-2049133/latest.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Physician approval for pregnancy in patients with SLE showing only serological activity: A vignette survey study |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10308 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2745 |
| primary_topic.subfield.display_name | Rheumatology |
| primary_topic.display_name | Systemic Lupus Erythematosus Research |
| related_works | https://openalex.org/W604999504, https://openalex.org/W582600639, https://openalex.org/W602594002, https://openalex.org/W1540446141, https://openalex.org/W2122528637, https://openalex.org/W2256177951, https://openalex.org/W2025210244, https://openalex.org/W1545219836, https://openalex.org/W2892200929, https://openalex.org/W2594063241 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-2049133/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402450 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Research Square (Research Square) |
| best_oa_location.source.host_organization | https://openalex.org/I4210096694 |
| best_oa_location.source.host_organization_name | Research Square (United States) |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-2049133/latest.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-2049133/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-2049133/v1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402450 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Research Square (Research Square) |
| primary_location.source.host_organization | https://openalex.org/I4210096694 |
| primary_location.source.host_organization_name | Research Square (United States) |
| primary_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-2049133/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-2049133/v1 |
| publication_date | 2022-09-15 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W1512626895, https://openalex.org/W2051192938, https://openalex.org/W2040536950, https://openalex.org/W2006132998, https://openalex.org/W2126550510, https://openalex.org/W2093457665, https://openalex.org/W2098776449, https://openalex.org/W2099437507, https://openalex.org/W2120496963, https://openalex.org/W1978562299, https://openalex.org/W1975250791, https://openalex.org/W1987876062, https://openalex.org/W2121601631, https://openalex.org/W2278093194, https://openalex.org/W2164357464, https://openalex.org/W1816170936, https://openalex.org/W1972663806, https://openalex.org/W2013578576, https://openalex.org/W2292584779, https://openalex.org/W2104729757, https://openalex.org/W2886510557, https://openalex.org/W2905401198, https://openalex.org/W1986056512, https://openalex.org/W2116971494, https://openalex.org/W1968221847 |
| referenced_works_count | 25 |
| abstract_inverted_index.A | 70 |
| abstract_inverted_index.a | 177, 201 |
| abstract_inverted_index.p | 156, 164, 170 |
| abstract_inverted_index.46 | 123 |
| abstract_inverted_index.It | 83 |
| abstract_inverted_index.be | 16 |
| abstract_inverted_index.by | 136 |
| abstract_inverted_index.if | 25, 188 |
| abstract_inverted_index.is | 33 |
| abstract_inverted_index.no | 191 |
| abstract_inverted_index.of | 10, 57, 87, 114, 120, 138, 180, 184, 210, 234 |
| abstract_inverted_index.on | 54, 204, 207 |
| abstract_inverted_index.or | 144 |
| abstract_inverted_index.to | 48, 75, 80, 109, 222, 230 |
| abstract_inverted_index.we | 46 |
| abstract_inverted_index.85% | 128 |
| abstract_inverted_index.The | 2, 105, 117 |
| abstract_inverted_index.age | 119 |
| abstract_inverted_index.and | 21, 90, 112, 127, 142 |
| abstract_inverted_index.are | 228 |
| abstract_inverted_index.for | 93, 95, 194 |
| abstract_inverted_index.had | 176, 200, 219 |
| abstract_inverted_index.how | 50 |
| abstract_inverted_index.six | 195 |
| abstract_inverted_index.the | 7, 55, 85, 91, 139, 208, 232 |
| abstract_inverted_index.was | 72, 107, 122, 133 |
| abstract_inverted_index.who | 217 |
| abstract_inverted_index.< | 157, 165, 171 |
| abstract_inverted_index.11.8 | 152 |
| abstract_inverted_index.2020 | 79 |
| abstract_inverted_index.9.4% | 113 |
| abstract_inverted_index.Even | 173 |
| abstract_inverted_index.even | 42 |
| abstract_inverted_index.from | 77 |
| abstract_inverted_index.have | 38, 66 |
| abstract_inverted_index.high | 145, 178 |
| abstract_inverted_index.make | 52 |
| abstract_inverted_index.mild | 143 |
| abstract_inverted_index.only | 65, 218 |
| abstract_inverted_index.p.p; | 163 |
| abstract_inverted_index.some | 36, 213 |
| abstract_inverted_index.such | 235 |
| abstract_inverted_index.that | 6 |
| abstract_inverted_index.were | 129, 190 |
| abstract_inverted_index.when | 59 |
| abstract_inverted_index.with | 61, 97 |
| abstract_inverted_index.-25.8 | 162 |
| abstract_inverted_index.-65.6 | 168 |
| abstract_inverted_index.20.5% | 183 |
| abstract_inverted_index.2021. | 82 |
| abstract_inverted_index.4,946 | 110 |
| abstract_inverted_index.EULAR | 3 |
| abstract_inverted_index.after | 43 |
| abstract_inverted_index.aimed | 47 |
| abstract_inverted_index.high. | 34 |
| abstract_inverted_index.high: | 167 |
| abstract_inverted_index.level | 179 |
| abstract_inverted_index.lupus | 12, 30, 63, 99 |
| abstract_inverted_index.mild: | 159 |
| abstract_inverted_index.p.p.; | 169 |
| abstract_inverted_index.there | 189 |
| abstract_inverted_index.using | 101 |
| abstract_inverted_index.while | 28 |
| abstract_inverted_index.0.001; | 158, 166 |
| abstract_inverted_index.become | 223 |
| abstract_inverted_index.before | 14 |
| abstract_inverted_index.effect | 203 |
| abstract_inverted_index.flares | 23 |
| abstract_inverted_index.median | 118 |
| abstract_inverted_index.occurs | 27 |
| abstract_inverted_index.online | 74 |
| abstract_inverted_index.points | 154 |
| abstract_inverted_index.stable | 17, 140 |
| abstract_inverted_index.though | 174 |
| abstract_inverted_index.years, | 126 |
| abstract_inverted_index.(range: | 124 |
| abstract_inverted_index.0.001). | 172 |
| abstract_inverted_index.Further | 225 |
| abstract_inverted_index.Herein, | 45 |
| abstract_inverted_index.January | 81 |
| abstract_inverted_index.[p.p.]; | 155 |
| abstract_inverted_index.allowed | 186, 215 |
| abstract_inverted_index.because | 18 |
| abstract_inverted_index.clarify | 231 |
| abstract_inverted_index.disease | 8, 22 |
| abstract_inverted_index.months. | 196 |
| abstract_inverted_index.ongoing | 39 |
| abstract_inverted_index.period, | 141 |
| abstract_inverted_index.studies | 227 |
| abstract_inverted_index.38–54) | 125 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.December | 78 |
| abstract_inverted_index.However, | 35 |
| abstract_inverted_index.Methods: | 69 |
| abstract_inverted_index.Results: | 104 |
| abstract_inverted_index.activity | 9, 32, 41, 199, 221 |
| abstract_inverted_index.affected | 135 |
| abstract_inverted_index.clinical | 192 |
| abstract_inverted_index.duration | 137 |
| abstract_inverted_index.included | 84 |
| abstract_inverted_index.increase | 24 |
| abstract_inverted_index.judgment | 206 |
| abstract_inverted_index.patients | 37, 60, 96, 175, 216 |
| abstract_inverted_index.required | 229 |
| abstract_inverted_index.requires | 5 |
| abstract_inverted_index.symptoms | 193 |
| abstract_inverted_index.systemic | 11, 29, 62, 98 |
| abstract_inverted_index.vignette | 102 |
| abstract_inverted_index.Pregnancy | 131 |
| abstract_inverted_index.activity, | 147, 182 |
| abstract_inverted_index.activity. | 68 |
| abstract_inverted_index.allowance | 92, 132 |
| abstract_inverted_index.decisions | 53 |
| abstract_inverted_index.patients. | 236 |
| abstract_inverted_index.physician | 205 |
| abstract_inverted_index.pregnancy | 15, 19, 26, 58, 187 |
| abstract_inverted_index.pregnant. | 224 |
| abstract_inverted_index.prognosis | 233 |
| abstract_inverted_index.(duration: | 149 |
| abstract_inverted_index.percentage | 153 |
| abstract_inverted_index.physicians | 51, 76, 115, 185, 214 |
| abstract_inverted_index.pregnancy. | 211 |
| abstract_inverted_index.proportion | 150, 160 |
| abstract_inverted_index.responded. | 116 |
| abstract_inverted_index.scenarios. | 103 |
| abstract_inverted_index.treatment. | 44 |
| abstract_inverted_index.Background: | 1 |
| abstract_inverted_index.Conversely, | 212 |
| abstract_inverted_index.Serological | 198 |
| abstract_inverted_index.difference, | 151, 161 |
| abstract_inverted_index.distributed | 108 |
| abstract_inverted_index.facilities, | 89 |
| abstract_inverted_index.investigate | 49 |
| abstract_inverted_index.physicians, | 88, 111 |
| abstract_inverted_index.pregnancies | 94 |
| abstract_inverted_index.respondents | 121 |
| abstract_inverted_index.serological | 40, 67, 146, 181, 220 |
| abstract_inverted_index.significant | 202 |
| abstract_inverted_index.Conclusions: | 197 |
| abstract_inverted_index.administered | 73 |
| abstract_inverted_index.respectively | 148 |
| abstract_inverted_index.acceptability | 56, 209 |
| abstract_inverted_index.complications | 20 |
| abstract_inverted_index.erythematosus | 13, 31, 64, 100 |
| abstract_inverted_index.observational | 226 |
| abstract_inverted_index.questionnaire | 71, 106 |
| abstract_inverted_index.significantly | 134 |
| abstract_inverted_index.recommendation | 4 |
| abstract_inverted_index.characteristics | 86 |
| abstract_inverted_index.rheumatologists. | 130 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.23297984 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |