Physicochemical quality assessment of various brands of paracetamol tablets sold in Freetown Municipality Article Swipe
Ahmed Vandy
,
Eugene BS Conteh
,
Michael Lahai
,
Marie Kolipha-Kamara
,
Mohamed Marah
,
Foday Marah
,
Kadiatu M. Suma
,
Sia C. Mattia
,
Kenneth D.S. Tucker
,
Victor S.E. Wray
,
Adama Koroma
,
Aiah Lebbie
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e25502
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e25502
Paracetamol is a widely used over-the-counter drug for managing fever and pain, but its quality may vary among different brands, especially in low- and middle-income countries, where counterfeit and substandard medicines are prevalent. This study evaluated the physicochemical properties of fifteen brands of 500 mg paracetamol tablets sold in various pharmacies in Freetown, Sierra Leone using identification tests, friability tests, assay, dissolution tests, and mass variation. The results showed that three brands were not registered with the Pharmacy Board of Sierra Leone, and two brands did not meet the requirement for labelling (no manufacturing date). All the brands met the requirement for mass variation, friability tests and assays. The percentage assay of the different brands ranged from 96.17 %w/w to 101.97 %w/w. However, two brands did not meet the specification for dissolution, with P012 releasing about 21.23 % ± 5.76 of the drug within 45min. Most of the paracetamol brands evaluated met the physicochemical test specification. However, two brands failed the dissolution test, two brands did not meet the labelling requirement and three brands were identified as unregistered products with the National Medicines Regulatory Authority in Sierra Leone. This study underscores the necessity of enhancing monitoring and post-market surveillance of pharmaceuticals in Sierra Leone to ensure they comply with regulatory requirements.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.heliyon.2024.e25502
- http://www.cell.com/article/S2405844024015330/pdf
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4391469959Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.heliyon.2024.e25502Digital Object Identifier
- Title
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Physicochemical quality assessment of various brands of paracetamol tablets sold in Freetown MunicipalityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-01Full publication date if available
- Authors
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Ahmed Vandy, Eugene BS Conteh, Michael Lahai, Marie Kolipha-Kamara, Mohamed Marah, Foday Marah, Kadiatu M. Suma, Sia C. Mattia, Kenneth D.S. Tucker, Victor S.E. Wray, Adama Koroma, Aiah LebbieList of authors in order
- Landing page
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https://doi.org/10.1016/j.heliyon.2024.e25502Publisher landing page
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https://www.cell.com/article/S2405844024015330/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.cell.com/article/S2405844024015330/pdfDirect OA link when available
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Quality (philosophy), Sierra leone, Traditional medicine, Business, Medicine, Socioeconomics, Sociology, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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