Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation Article Swipe
Ioana Chelcea
,
Stefan Örn
,
Timo Hamers
,
Jacco Koekkoek
,
Jessica Legradi
,
Carolina Vogs
,
Patrik L. Andersson
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acs.est.2c01292
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acs.est.2c01292
Bisphenol A (BPA) is an industrial chemical, which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogues are less well-studied despite their wide use in consumer products. These analogues have been detected in water and aquatic organisms around the world, with some analogues showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicological relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiologically based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to experimental data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.est.2c01292
- https://pubs.acs.org/doi/pdf/10.1021/acs.est.2c01292
- OA Status
- hybrid
- Cited By
- 33
- References
- 87
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4284892499
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- OpenAlex ID
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https://openalex.org/W4284892499Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.est.2c01292Digital Object Identifier
- Title
-
Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver AccumulationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-07Full publication date if available
- Authors
-
Ioana Chelcea, Stefan Örn, Timo Hamers, Jacco Koekkoek, Jessica Legradi, Carolina Vogs, Patrik L. AnderssonList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.est.2c01292Publisher landing page
- PDF URL
-
https://pubs.acs.org/doi/pdf/10.1021/acs.est.2c01292Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://pubs.acs.org/doi/pdf/10.1021/acs.est.2c01292Direct OA link when available
- Concepts
-
Danio, Zebrafish, Toxicokinetics, Biotransformation, Environmental chemistry, Bioaccumulation, Biology, Pollutant, Bisphenol A, Toxicity, Fish
, Chemistry, Toxicology, Pharmacology, Biochemistry, Ecology, Pharmacokinetics, Fishery, Organic chemistry, Enzyme, Epoxy, Gene Top concepts (fields/topics) attached by OpenAlex - Cited by
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33Total citation count in OpenAlex
- Citations by year (recent)
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2025: 13, 2024: 15, 2023: 5Per-year citation counts (last 5 years)
- References (count)
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87Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.brain | 125 |
| abstract_inverted_index.data, | 140 |
| abstract_inverted_index.error | 135 |
| abstract_inverted_index.fish. | 55 |
| abstract_inverted_index.group | 194 |
| abstract_inverted_index.human | 10 |
| abstract_inverted_index.liver | 151 |
| abstract_inverted_index.model | 106, 179 |
| abstract_inverted_index.novel | 59 |
| abstract_inverted_index.organ | 84 |
| abstract_inverted_index.rates | 94 |
| abstract_inverted_index.their | 26 |
| abstract_inverted_index.these | 112 |
| abstract_inverted_index.toxic | 49 |
| abstract_inverted_index.water | 38 |
| abstract_inverted_index.which | 7, 114 |
| abstract_inverted_index.whole | 130 |
| abstract_inverted_index.(PBTK) | 105 |
| abstract_inverted_index.around | 42 |
| abstract_inverted_index.brain, | 80 |
| abstract_inverted_index.brain. | 177 |
| abstract_inverted_index.female | 69 |
| abstract_inverted_index.gonads | 172 |
| abstract_inverted_index.health | 11 |
| abstract_inverted_index.levels | 119 |
| abstract_inverted_index.liver, | 78, 123 |
| abstract_inverted_index.mainly | 166 |
| abstract_inverted_index.organs | 145 |
| abstract_inverted_index.raised | 9 |
| abstract_inverted_index.rarely | 82 |
| abstract_inverted_index.target | 144 |
| abstract_inverted_index.within | 132 |
| abstract_inverted_index.world, | 44 |
| abstract_inverted_index.adapted | 108 |
| abstract_inverted_index.aquatic | 40 |
| abstract_inverted_index.carcass | 170 |
| abstract_inverted_index.despite | 25 |
| abstract_inverted_index.effects | 50 |
| abstract_inverted_index.gonads, | 122 |
| abstract_inverted_index.models. | 159 |
| abstract_inverted_index.predict | 118 |
| abstract_inverted_index.present | 58 |
| abstract_inverted_index.respect | 137 |
| abstract_inverted_index.sampled | 83 |
| abstract_inverted_index.several | 142 |
| abstract_inverted_index.showing | 48 |
| abstract_inverted_index.species | 53 |
| abstract_inverted_index.studied | 164 |
| abstract_inverted_index.various | 52 |
| abstract_inverted_index.2-5-fold | 134 |
| abstract_inverted_index.compared | 154 |
| abstract_inverted_index.concerns | 14 |
| abstract_inverted_index.consumer | 30 |
| abstract_inverted_index.covering | 141 |
| abstract_inverted_index.detected | 36 |
| abstract_inverted_index.emerging | 196 |
| abstract_inverted_index.improved | 153 |
| abstract_inverted_index.increase | 184 |
| abstract_inverted_index.indicate | 162 |
| abstract_inverted_index.kinetics | 191 |
| abstract_inverted_index.ovaries, | 77 |
| abstract_inverted_index.provides | 180 |
| abstract_inverted_index.selected | 99 |
| abstract_inverted_index.(<i>Danio | 71 |
| abstract_inverted_index.Bisphenol | 0 |
| abstract_inverted_index.Predicted | 160 |
| abstract_inverted_index.analogues | 21, 33, 47 |
| abstract_inverted_index.available | 157 |
| abstract_inverted_index.bisphenol | 65 |
| abstract_inverted_index.chemical, | 6 |
| abstract_inverted_index.currently | 156 |
| abstract_inverted_index.important | 143 |
| abstract_inverted_index.including | 54, 73 |
| abstract_inverted_index.organisms | 41 |
| abstract_inverted_index.predicted | 150 |
| abstract_inverted_index.products. | 31 |
| abstract_inverted_index.toxicity. | 147 |
| abstract_inverted_index.vitro</i> | 92 |
| abstract_inverted_index.zebrafish | 70 |
| abstract_inverted_index.bisphenols | 165 |
| abstract_inverted_index.determined | 96 |
| abstract_inverted_index.distribute | 167 |
| abstract_inverted_index.industrial | 5 |
| abstract_inverted_index.relevance. | 88 |
| abstract_inverted_index.bisphenols, | 113 |
| abstract_inverted_index.bisphenols. | 100 |
| abstract_inverted_index.particular, | 149 |
| abstract_inverted_index.pollutants. | 197 |
| abstract_inverted_index.properties. | 19 |
| abstract_inverted_index.rerio</i>), | 72 |
| abstract_inverted_index.time-course | 61 |
| abstract_inverted_index.Furthermore, | 89 |
| abstract_inverted_index.distribution | 62, 189 |
| abstract_inverted_index.experimental | 139 |
| abstract_inverted_index.well-studied | 24 |
| abstract_inverted_index.environmental | 13 |
| abstract_inverted_index.fish-specific | 90 |
| abstract_inverted_index.toxicokinetic | 104 |
| abstract_inverted_index.toxicological | 87 |
| abstract_inverted_index.understanding | 186 |
| abstract_inverted_index.concentrations | 74, 152 |
| abstract_inverted_index.organ-specific | 60 |
| abstract_inverted_index.physiologically | 102 |
| abstract_inverted_index.biotransformation | 93 |
| abstract_inverted_index.endocrine-disrupting | 18 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5023275578 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I90267481 |
| citation_normalized_percentile.value | 0.94024999 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |