Phytochemical Profiling and Toxicity Assessment of Aqueous Extract From Bitter Apricot Kernels Cultivated in Morocco Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.1155/sci5/5757744
Apricot kernels contain amygdalin, a cyanogenic glycoside that degrades to cyanide upon chewing or crushing, posing a potential toxicity risk to humans. The present study aimed to determine the phenolic compounds and to evaluate the subacute and acute toxicity of the aqueous extract of bitter apricot kernels (BAKs) in Swiss albino mice. The chemical characterization was carried out with HPLC‐DAD analyses, and acute toxicity was done by extract’s oral administration once for 72‐h period at doses of 500–6000 mg/kg body weight (bw). For the subacute toxicity, mice were administrated orally by repeated doses of 100, 500, and 1000 mg/kg bw for 28 days. The hematological, biochemical parameters and the histological examinations of vital organs (kidney, liver, and spleen) were done by sacrificing the animals after the subacute toxicity period. The results revealed 11 phenolic compounds with a total of 61 mg/g of extract. In the acute toxicity study, no signs of toxicity or mortality were observed during the experiment period, and the LD 50 value was higher than 6000 mg/kg bw. In the subacute toxicity, only the group treated with the greatest dose (1000 mg/kg bw) exhibited a significant decrease in the hematocrit and slight increase in urea, and creatinine. The results of this study indicate that the aqueous extract of BAK was not toxic to mice at the tested concentrations. This provides valuable information regarding its toxicity profile.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/sci5/5757744
- OA Status
- gold
- Cited By
- 2
- References
- 41
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4407670905Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/sci5/5757744Digital Object Identifier
- Title
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Phytochemical Profiling and Toxicity Assessment of Aqueous Extract From Bitter Apricot Kernels Cultivated in MoroccoWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
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Mohamed Amine El-Hajjaji, Ghizlane Nouioura, Kawtar Fikri-Benbrahim, Najoua Soulo, Mohammed El Ouassete, Badiâa Lyoussi, Zineb Benziane OuaritiniList of authors in order
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https://doi.org/10.1155/sci5/5757744Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1155/sci5/5757744Direct OA link when available
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Phytochemical, Profiling (computer programming), Traditional medicine, Toxicity, Chemistry, Biology, Botany, Computer science, Medicine, Organic chemistry, Operating systemTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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