Phytochemical prospection of <em>Azadirachta indica</em> stem bark ethanolic extract and evaluation of its toxicity against <em>Drosophila melanogaster</em> Article Swipe
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· 2018
· Open Access
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· DOI: https://doi.org/10.3390/mol2net-04-05555
Azadirachta indica is a plant of the family Meliaceae, originating in India, whose secondary metabolites are used for medicinal and insect purposes. The fruit fly - Drosophila melanogater is widely cited in the literature as a model for toxicity testing, especially since it presents rapid development and low maintenance cost. The aim of the present work was to carry out a phytochemical prospection of the ethanolic extract of A. indica stem bark (EECAi) and analyze its toxicity against D. melanogaster. The Colorimetric Method performed the chemical gait. The flies were submitted to different concentrations of the EECAi (5 mg / mL, 10 mg / mL and 20 mg / mL), being readings of 3 h, 6 h, 12 h, 24 h and 48 h, with light / dark cycles of 12 hours. Mortality rates and damage to the locomotor apparatus were analyzed by negative geotaxia test. Phytochemical prospecting of EECAi indicated the presence of tannins, flavones, flavonols, flavonones, flavononols, xanthones, chalcones, aurones and leocoantocyanidins. This extract did not present significant toxicity when compared to the control. The damage to the locomotor system was more significant at concentrations of 10 mg / mL and 20 mg / mL, in the 24 h and 48 h readings. The results of the mortality rate showed that the EECAi showed no significant toxicity at the concentrations and the model tested, diverging from other studies suggesting a bioinsecticity of this plant. Further studies need to test compounds isolated from this plant. .
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/mol2net-04-05555
- https://sciforum.net/paper/download/5555/slides
- OA Status
- hybrid
- References
- 4
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- OpenAlex ID
- https://openalex.org/W2921651726
Raw OpenAlex JSON
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https://openalex.org/W2921651726Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/mol2net-04-05555Digital Object Identifier
- Title
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Phytochemical prospection of <em>Azadirachta indica</em> stem bark ethanolic extract and evaluation of its toxicity against <em>Drosophila melanogaster</em>Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-10-25Full publication date if available
- Authors
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Paula Patrícia Marques Cordeiro, Dárcio Luiz de Sousa Júnior, Joycy Francely Sampaio dos Santos, Larissa da Silva, Luiz Jardelino de Lacerda Neto, Maria Apoliana Costa dos Santos, Francisco Assis Bezerra da Cunha, Henrique Douglas Melo CoutinhoList of authors in order
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https://doi.org/10.3390/mol2net-04-05555Publisher landing page
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https://sciforum.net/paper/download/5555/slidesDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://sciforum.net/paper/download/5555/slidesDirect OA link when available
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Phytochemical, Azadirachta, Toxicity, Acute toxicity, Traditional medicine, Biology, Flavones, Toxicology, Meliaceae, Botany, Horticulture, Chemistry, Medicine, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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4Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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