PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions Article Swipe
Karina Sánchez‐Alegría
,
Manuel Flores‐León
,
Evangelina Ávila-Muñoz
,
Nelly Rodríguez-Corona
,
Clorinda Arias
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/ijms19123725
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/ijms19123725
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. Less is known regarding its critical role in neuronal physiology, neuronal metabolism, tissue homeostasis, and the control of gene expression in the central nervous system in healthy and diseased states. The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms19123725
- https://www.mdpi.com/1422-0067/19/12/3725/pdf
- OA Status
- gold
- Cited By
- 178
- References
- 117
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W2901671636Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms19123725Digital Object Identifier
- Title
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PI3K Signaling in Neurons: A Central Node for the Control of Multiple FunctionsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
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2018Year of publication
- Publication date
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2018-11-23Full publication date if available
- Authors
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Karina Sánchez‐Alegría, Manuel Flores‐León, Evangelina Ávila-Muñoz, Nelly Rodríguez-Corona, Clorinda AriasList of authors in order
- Landing page
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https://doi.org/10.3390/ijms19123725Publisher landing page
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https://www.mdpi.com/1422-0067/19/12/3725/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/19/12/3725/pdfDirect OA link when available
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Biology, PI3K/AKT/mTOR pathway, Neurodegeneration, Neuroscience, Anabolism, Cell biology, Signal transduction, Endocrinology, Internal medicine, Medicine, DiseaseTop concepts (fields/topics) attached by OpenAlex
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178Total citation count in OpenAlex
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2025: 34, 2024: 31, 2023: 25, 2022: 31, 2021: 29Per-year citation counts (last 5 years)
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117Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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