PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice Article Swipe
Mouin Nasr
,
Alexis Fay
,
Adrien Lupieri
,
Nicole Malet
,
Anne Darmon
,
Rana Zahreddine
,
Audrey Swiader
,
Amandine Wahart
,
Julien Viaud
,
Anne Nègre‐Salvayre
,
Emilio Hirsch
,
Daniel Monteyne
,
David Pérez‐Morga
,
Nicolas Dupont
,
Patrice Codogno
,
Damien Ramel
,
Étienne Morel
,
Muriel Laffargue
,
Stéphanie Gayral
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1161/atvbaha.123.319978
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1161/atvbaha.123.319978
BACKGROUND: The ability to respond to mechanical forces is a basic requirement for maintaining endothelial cell (ECs) homeostasis, which is continuously subjected to low shear stress (LSS) and high shear stress (HSS). In arteries, LSS and HSS have a differential impact on EC autophagy processes. However, it is still unclear whether LSS and HSS differently tune unique autophagic machinery or trigger specific autophagic responses in ECs. METHODS: Using fluid flow system to generate forces on EC and multiscale imaging analyses on ApoE −/− mice whole arteries, we studied the cellular and molecular mechanism involved in autophagic response to LSS or HSS on the endothelium. RESULTS: We found that LSS and HSS trigger autophagy activation by mobilizing specific autophagic signaling modules. Indeed, LSS-induced autophagy in endothelium was independent of the class III PI3K (phosphoinositide 3-kinase) VPS34 (vacuolar sorting protein 34) but controlled by the α isoform of class II PI3K (phosphoinositide 3-kinase class II α [PI3KCIIα]). Accordingly, reduced PI3KCIIα expression in ApoE −/− mice (ApoE −/− PI3KCIIα +/− ) led to EC dysfunctions associated with increased plaque deposition in the LSS regions. Mechanistically, we revealed that PI3KCIIα inhibits mTORC1 (mammalian target of rapamycin complex 1) activation and that rapamycin treatment in ApoE −/− PI3KCIIα +/− mice specifically rescue autophagy in arterial LSS regions. Finally, we demonstrated that absence of PI3KCIIα led to decreased endothelial primary cilium biogenesis in response to LSS and that ablation of primary cilium mimics PI3KCIIα-decreased expression in EC dysfunction, suggesting that this organelle could be the mechanosensor linking PI3KCIIα and EC homeostasis. CONCLUSIONS: Our data reveal that mechanical forces variability within the arterial system determines EC autophagic response and supports a central role of PI3KCIIα/mTORC1 axis to prevent EC dysfunction in LSS regions.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/atvbaha.123.319978
- OA Status
- green
- Cited By
- 8
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390344713
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390344713Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/atvbaha.123.319978Digital Object Identifier
- Title
-
PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in MiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-28Full publication date if available
- Authors
-
Mouin Nasr, Alexis Fay, Adrien Lupieri, Nicole Malet, Anne Darmon, Rana Zahreddine, Audrey Swiader, Amandine Wahart, Julien Viaud, Anne Nègre‐Salvayre, Emilio Hirsch, Daniel Monteyne, David Pérez‐Morga, Nicolas Dupont, Patrice Codogno, Damien Ramel, Étienne Morel, Muriel Laffargue, Stéphanie GayralList of authors in order
- Landing page
-
https://doi.org/10.1161/atvbaha.123.319978Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://hal.science/hal-04520255Direct OA link when available
- Concepts
-
Autophagy, Cell biology, PI3K/AKT/mTOR pathway, Unfolded protein response, Endothelium, Biology, Chemistry, Signal transduction, Apoptosis, Endocrinology, Endoplasmic reticulum, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4390344713 |
|---|---|
| doi | https://doi.org/10.1161/atvbaha.123.319978 |
| ids.doi | https://doi.org/10.1161/atvbaha.123.319978 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38152888 |
| ids.openalex | https://openalex.org/W4390344713 |
| fwci | 2.82443517 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D051379 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Mice |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D006801 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Humans |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D002478 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Cells, Cultured |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D019869 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Phosphatidylinositol 3-Kinases |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D050197 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Atherosclerosis |
| mesh[6].qualifier_ui | Q000517 |
| mesh[6].descriptor_ui | D050197 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | prevention & control |
| mesh[6].descriptor_name | Atherosclerosis |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D050197 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Atherosclerosis |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D000076222 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Mechanistic Target of Rapamycin Complex 1 |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D001343 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Autophagy |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D058539 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Phosphatidylinositol 3-Kinase |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D001057 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Apolipoproteins E |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D001057 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Apolipoproteins E |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D013314 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Stress, Mechanical |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D061307 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Human Umbilical Vein Endothelial Cells |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D008322 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Mammals |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D000818 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Animals |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D006801 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Humans |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D051379 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Mice |
| mesh[19].qualifier_ui | Q000235 |
| mesh[19].descriptor_ui | D001057 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | genetics |
| mesh[19].descriptor_name | Apolipoproteins E |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D001057 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Apolipoproteins E |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D050197 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | Atherosclerosis |
| mesh[22].qualifier_ui | Q000517 |
| mesh[22].descriptor_ui | D050197 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | prevention & control |
| mesh[22].descriptor_name | Atherosclerosis |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D050197 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Atherosclerosis |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D001343 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Autophagy |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D002478 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Cells, Cultured |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D061307 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Human Umbilical Vein Endothelial Cells |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008322 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Mammals |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D000076222 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Mechanistic Target of Rapamycin Complex 1 |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D013314 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Stress, Mechanical |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D058534 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Class I Phosphatidylinositol 3-Kinases |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D000818 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Animals |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D006801 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Humans |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D051379 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Mice |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D001057 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | Apolipoproteins E |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D001057 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Apolipoproteins E |
| mesh[36].qualifier_ui | Q000235 |
| mesh[36].descriptor_ui | D050197 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | genetics |
| mesh[36].descriptor_name | Atherosclerosis |
| mesh[37].qualifier_ui | Q000517 |
| mesh[37].descriptor_ui | D050197 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | prevention & control |
| mesh[37].descriptor_name | Atherosclerosis |
| mesh[38].qualifier_ui | Q000378 |
| mesh[38].descriptor_ui | D050197 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | metabolism |
| mesh[38].descriptor_name | Atherosclerosis |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D001343 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Autophagy |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D002478 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Cells, Cultured |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D061307 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Human Umbilical Vein Endothelial Cells |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D008322 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Mammals |
| mesh[43].qualifier_ui | Q000378 |
| mesh[43].descriptor_ui | D000076222 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | metabolism |
| mesh[43].descriptor_name | Mechanistic Target of Rapamycin Complex 1 |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D013314 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Stress, Mechanical |
| mesh[45].qualifier_ui | Q000378 |
| mesh[45].descriptor_ui | D058534 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | metabolism |
| mesh[45].descriptor_name | Class I Phosphatidylinositol 3-Kinases |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D051379 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Mice |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D000818 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Animals |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D006801 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Humans |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D002478 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Cells, Cultured |
| type | article |
| title | PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice |
| biblio.issue | 3 |
| biblio.volume | 44 |
| biblio.last_page | 634 |
| biblio.first_page | 620 |
| topics[0].id | https://openalex.org/T10587 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Autophagy in Disease and Therapy |
| topics[1].id | https://openalex.org/T12065 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9587000012397766 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Hippo pathway signaling and YAP/TAZ |
| topics[2].id | https://openalex.org/T12672 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.942300021648407 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Phagocytosis and Immune Regulation |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C203522944 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8843684792518616 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q288322 |
| concepts[0].display_name | Autophagy |
| concepts[1].id | https://openalex.org/C95444343 |
| concepts[1].level | 1 |
| concepts[1].score | 0.6987495422363281 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[1].display_name | Cell biology |
| concepts[2].id | https://openalex.org/C86554907 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5540112257003784 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q285613 |
| concepts[2].display_name | PI3K/AKT/mTOR pathway |
| concepts[3].id | https://openalex.org/C139447449 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5194522738456726 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q14633900 |
| concepts[3].display_name | Unfolded protein response |
| concepts[4].id | https://openalex.org/C2776992346 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4719756543636322 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q111140 |
| concepts[4].display_name | Endothelium |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4240502119064331 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.35030311346054077 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C62478195 |
| concepts[7].level | 2 |
| concepts[7].score | 0.28761419653892517 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[7].display_name | Signal transduction |
| concepts[8].id | https://openalex.org/C190283241 |
| concepts[8].level | 2 |
| concepts[8].score | 0.193646639585495 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[8].display_name | Apoptosis |
| concepts[9].id | https://openalex.org/C134018914 |
| concepts[9].level | 1 |
| concepts[9].score | 0.16835373640060425 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[9].display_name | Endocrinology |
| concepts[10].id | https://openalex.org/C158617107 |
| concepts[10].level | 2 |
| concepts[10].score | 0.14792069792747498 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q79927 |
| concepts[10].display_name | Endoplasmic reticulum |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.09396705031394958 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/autophagy |
| keywords[0].score | 0.8843684792518616 |
| keywords[0].display_name | Autophagy |
| keywords[1].id | https://openalex.org/keywords/cell-biology |
| keywords[1].score | 0.6987495422363281 |
| keywords[1].display_name | Cell biology |
| keywords[2].id | https://openalex.org/keywords/pi3k/akt/mtor-pathway |
| keywords[2].score | 0.5540112257003784 |
| keywords[2].display_name | PI3K/AKT/mTOR pathway |
| keywords[3].id | https://openalex.org/keywords/unfolded-protein-response |
| keywords[3].score | 0.5194522738456726 |
| keywords[3].display_name | Unfolded protein response |
| keywords[4].id | https://openalex.org/keywords/endothelium |
| keywords[4].score | 0.4719756543636322 |
| keywords[4].display_name | Endothelium |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4240502119064331 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.35030311346054077 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/signal-transduction |
| keywords[7].score | 0.28761419653892517 |
| keywords[7].display_name | Signal transduction |
| keywords[8].id | https://openalex.org/keywords/apoptosis |
| keywords[8].score | 0.193646639585495 |
| keywords[8].display_name | Apoptosis |
| keywords[9].id | https://openalex.org/keywords/endocrinology |
| keywords[9].score | 0.16835373640060425 |
| keywords[9].display_name | Endocrinology |
| keywords[10].id | https://openalex.org/keywords/endoplasmic-reticulum |
| keywords[10].score | 0.14792069792747498 |
| keywords[10].display_name | Endoplasmic reticulum |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.09396705031394958 |
| keywords[11].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1161/atvbaha.123.319978 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S3485792 |
| locations[0].source.issn | 1079-5642, 1524-4636 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1079-5642 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Arteriosclerosis Thrombosis and Vascular Biology |
| locations[0].source.host_organization | https://openalex.org/P4310315671 |
| locations[0].source.host_organization_name | Lippincott Williams & Wilkins |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315671 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Arteriosclerosis, Thrombosis, and Vascular Biology |
| locations[0].landing_page_url | https://doi.org/10.1161/atvbaha.123.319978 |
| locations[1].id | pmid:38152888 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Arteriosclerosis, thrombosis, and vascular biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38152888 |
| locations[2].id | pmh:oai:HAL:hal-04520255v1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Arteriosclerosis, Thrombosis, and Vascular Biology, 2024, 44 (3), pp.620-634. ⟨10.1161/ATVBAHA.123.319978⟩ |
| locations[2].landing_page_url | https://hal.science/hal-04520255 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5024617856 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Mouin Nasr |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[0].institutions[0].id | https://openalex.org/I154526488 |
| authorships[0].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Inserm |
| authorships[0].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[0].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Mouin Nasr |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[1].author.id | https://openalex.org/A5011217086 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Alexis Fay |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[1].institutions[0].id | https://openalex.org/I154526488 |
| authorships[1].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Inserm |
| authorships[1].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[1].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[1].institutions[1].type | facility |
| authorships[1].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Alexis Fay |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[2].author.id | https://openalex.org/A5064177299 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9245-0169 |
| authorships[2].author.display_name | Adrien Lupieri |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[2].institutions[0].id | https://openalex.org/I154526488 |
| authorships[2].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Inserm |
| authorships[2].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[2].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Adrien Lupieri |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[3].author.id | https://openalex.org/A5077342266 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Nicole Malet |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[3].institutions[0].id | https://openalex.org/I154526488 |
| authorships[3].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Inserm |
| authorships[3].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[3].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nicole Malet |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[4].author.id | https://openalex.org/A5109398148 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Anne Darmon |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[4].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[4].institutions[0].id | https://openalex.org/I154526488 |
| authorships[4].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Inserm |
| authorships[4].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[4].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[4].institutions[1].type | facility |
| authorships[4].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Anne Darmon |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[5].author.id | https://openalex.org/A5050242901 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1291-6879 |
| authorships[5].author.display_name | Rana Zahreddine |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[5].institutions[0].id | https://openalex.org/I154526488 |
| authorships[5].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Inserm |
| authorships[5].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[5].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[5].institutions[1].type | facility |
| authorships[5].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[5].institutions[1].country_code | FR |
| authorships[5].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Rana Zahreddine |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[6].author.id | https://openalex.org/A5050599133 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6050-4337 |
| authorships[6].author.display_name | Audrey Swiader |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[6].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[6].institutions[0].id | https://openalex.org/I154526488 |
| authorships[6].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Inserm |
| authorships[6].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[6].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Audrey Swiader |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[7].author.id | https://openalex.org/A5012424074 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-7035-665X |
| authorships[7].author.display_name | Amandine Wahart |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[7].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[7].institutions[0].id | https://openalex.org/I154526488 |
| authorships[7].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | Inserm |
| authorships[7].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[7].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[7].institutions[1].type | facility |
| authorships[7].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[7].institutions[1].country_code | FR |
| authorships[7].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Amandine Wahart |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[8].author.id | https://openalex.org/A5039799636 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-4406-5642 |
| authorships[8].author.display_name | Julien Viaud |
| authorships[8].countries | FR |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[8].institutions[0].id | https://openalex.org/I154526488 |
| authorships[8].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[8].institutions[0].country_code | FR |
| authorships[8].institutions[0].display_name | Inserm |
| authorships[8].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[8].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[8].institutions[1].country_code | FR |
| authorships[8].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Julien Viaud |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[9].author.id | https://openalex.org/A5041960151 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-2136-5706 |
| authorships[9].author.display_name | Anne Nègre‐Salvayre |
| authorships[9].countries | FR |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[9].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[9].institutions[0].id | https://openalex.org/I154526488 |
| authorships[9].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[9].institutions[0].country_code | FR |
| authorships[9].institutions[0].display_name | Inserm |
| authorships[9].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[9].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[9].institutions[1].type | facility |
| authorships[9].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[9].institutions[1].country_code | FR |
| authorships[9].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Anne Nègre-Salvayre |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[10].author.id | https://openalex.org/A5085452501 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9073-6024 |
| authorships[10].author.display_name | Emilio Hirsch |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I55143463 |
| authorships[10].affiliations[0].raw_affiliation_string | Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy (E.H.). |
| authorships[10].institutions[0].id | https://openalex.org/I55143463 |
| authorships[10].institutions[0].ror | https://ror.org/048tbm396 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I55143463 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | University of Turin |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Emilio Hirsch |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy (E.H.). |
| authorships[11].author.id | https://openalex.org/A5033434561 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-2529-2455 |
| authorships[11].author.display_name | Daniel Monteyne |
| authorships[11].affiliations[0].raw_affiliation_string | IBMM-DBM - IBMM-DBM, Department of Molecular Parasitology, University of Brussels, Gosselies, Belgium (Belgium) |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Daniel Monteyne |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | IBMM-DBM - IBMM-DBM, Department of Molecular Parasitology, University of Brussels, Gosselies, Belgium (Belgium) |
| authorships[12].author.id | https://openalex.org/A5029142611 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-7168-1865 |
| authorships[12].author.display_name | David Pérez‐Morga |
| authorships[12].affiliations[0].raw_affiliation_string | IBMM-DBM - IBMM-DBM, Department of Molecular Parasitology, University of Brussels, Gosselies, Belgium (Belgium) |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | David Perez-Morgà |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | IBMM-DBM - IBMM-DBM, Department of Molecular Parasitology, University of Brussels, Gosselies, Belgium (Belgium) |
| authorships[13].author.id | https://openalex.org/A5076945285 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-3056-9906 |
| authorships[13].author.display_name | Nicolas Dupont |
| authorships[13].countries | FR |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210091437 |
| authorships[13].affiliations[0].raw_affiliation_string | Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, France (N.D., P.C., E.M.). |
| authorships[13].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[13].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[13].institutions[0].type | government |
| authorships[13].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[13].institutions[0].country_code | FR |
| authorships[13].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[13].institutions[1].id | https://openalex.org/I154526488 |
| authorships[13].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[13].institutions[1].type | government |
| authorships[13].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[13].institutions[1].country_code | FR |
| authorships[13].institutions[1].display_name | Inserm |
| authorships[13].institutions[2].id | https://openalex.org/I4210086369 |
| authorships[13].institutions[2].ror | https://ror.org/000nhq538 |
| authorships[13].institutions[2].type | facility |
| authorships[13].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[13].institutions[2].country_code | FR |
| authorships[13].institutions[2].display_name | Institut Necker Enfants Malades |
| authorships[13].institutions[3].id | https://openalex.org/I4210091437 |
| authorships[13].institutions[3].ror | https://ror.org/001z21q04 |
| authorships[13].institutions[3].type | other |
| authorships[13].institutions[3].lineage | https://openalex.org/I4210091437 |
| authorships[13].institutions[3].country_code | FR |
| authorships[13].institutions[3].display_name | Sorbonne Paris Cité |
| authorships[13].institutions[4].id | https://openalex.org/I204730241 |
| authorships[13].institutions[4].ror | https://ror.org/05f82e368 |
| authorships[13].institutions[4].type | education |
| authorships[13].institutions[4].lineage | https://openalex.org/I204730241 |
| authorships[13].institutions[4].country_code | FR |
| authorships[13].institutions[4].display_name | Université Paris Cité |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Nicolas Dupont |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, France (N.D., P.C., E.M.). |
| authorships[14].author.id | https://openalex.org/A5051700932 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-5492-3180 |
| authorships[14].author.display_name | Patrice Codogno |
| authorships[14].countries | FR |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210091437 |
| authorships[14].affiliations[0].raw_affiliation_string | Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, France (N.D., P.C., E.M.). |
| authorships[14].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[14].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[14].institutions[0].type | government |
| authorships[14].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[14].institutions[0].country_code | FR |
| authorships[14].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[14].institutions[1].id | https://openalex.org/I154526488 |
| authorships[14].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[14].institutions[1].type | government |
| authorships[14].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[14].institutions[1].country_code | FR |
| authorships[14].institutions[1].display_name | Inserm |
| authorships[14].institutions[2].id | https://openalex.org/I4210086369 |
| authorships[14].institutions[2].ror | https://ror.org/000nhq538 |
| authorships[14].institutions[2].type | facility |
| authorships[14].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[14].institutions[2].country_code | FR |
| authorships[14].institutions[2].display_name | Institut Necker Enfants Malades |
| authorships[14].institutions[3].id | https://openalex.org/I4210091437 |
| authorships[14].institutions[3].ror | https://ror.org/001z21q04 |
| authorships[14].institutions[3].type | other |
| authorships[14].institutions[3].lineage | https://openalex.org/I4210091437 |
| authorships[14].institutions[3].country_code | FR |
| authorships[14].institutions[3].display_name | Sorbonne Paris Cité |
| authorships[14].institutions[4].id | https://openalex.org/I204730241 |
| authorships[14].institutions[4].ror | https://ror.org/05f82e368 |
| authorships[14].institutions[4].type | education |
| authorships[14].institutions[4].lineage | https://openalex.org/I204730241 |
| authorships[14].institutions[4].country_code | FR |
| authorships[14].institutions[4].display_name | Université Paris Cité |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Patrice Codogno |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, France (N.D., P.C., E.M.). |
| authorships[15].author.id | https://openalex.org/A5052579243 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-9089-1497 |
| authorships[15].author.display_name | Damien Ramel |
| authorships[15].countries | FR |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[15].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[15].institutions[0].id | https://openalex.org/I154526488 |
| authorships[15].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[15].institutions[0].type | government |
| authorships[15].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[15].institutions[0].country_code | FR |
| authorships[15].institutions[0].display_name | Inserm |
| authorships[15].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[15].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[15].institutions[1].type | facility |
| authorships[15].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[15].institutions[1].country_code | FR |
| authorships[15].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Damien Ramel |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[16].author.id | https://openalex.org/A5066716504 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-4763-4954 |
| authorships[16].author.display_name | Étienne Morel |
| authorships[16].countries | FR |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210091437 |
| authorships[16].affiliations[0].raw_affiliation_string | Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, France (N.D., P.C., E.M.). |
| authorships[16].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[16].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[16].institutions[0].type | government |
| authorships[16].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[16].institutions[0].country_code | FR |
| authorships[16].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[16].institutions[1].id | https://openalex.org/I154526488 |
| authorships[16].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[16].institutions[1].type | government |
| authorships[16].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[16].institutions[1].country_code | FR |
| authorships[16].institutions[1].display_name | Inserm |
| authorships[16].institutions[2].id | https://openalex.org/I4210086369 |
| authorships[16].institutions[2].ror | https://ror.org/000nhq538 |
| authorships[16].institutions[2].type | facility |
| authorships[16].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210086369, https://openalex.org/I4210096427 |
| authorships[16].institutions[2].country_code | FR |
| authorships[16].institutions[2].display_name | Institut Necker Enfants Malades |
| authorships[16].institutions[3].id | https://openalex.org/I4210091437 |
| authorships[16].institutions[3].ror | https://ror.org/001z21q04 |
| authorships[16].institutions[3].type | other |
| authorships[16].institutions[3].lineage | https://openalex.org/I4210091437 |
| authorships[16].institutions[3].country_code | FR |
| authorships[16].institutions[3].display_name | Sorbonne Paris Cité |
| authorships[16].institutions[4].id | https://openalex.org/I204730241 |
| authorships[16].institutions[4].ror | https://ror.org/05f82e368 |
| authorships[16].institutions[4].type | education |
| authorships[16].institutions[4].lineage | https://openalex.org/I204730241 |
| authorships[16].institutions[4].country_code | FR |
| authorships[16].institutions[4].display_name | Université Paris Cité |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Etienne Morel |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, France (N.D., P.C., E.M.). |
| authorships[17].author.id | https://openalex.org/A5055194734 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-1833-639X |
| authorships[17].author.display_name | Muriel Laffargue |
| authorships[17].countries | FR |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[17].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[17].institutions[0].id | https://openalex.org/I154526488 |
| authorships[17].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[17].institutions[0].type | government |
| authorships[17].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[17].institutions[0].country_code | FR |
| authorships[17].institutions[0].display_name | Inserm |
| authorships[17].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[17].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[17].institutions[1].type | facility |
| authorships[17].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[17].institutions[1].country_code | FR |
| authorships[17].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Muriel Laffargue |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[18].author.id | https://openalex.org/A5011334246 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-6276-3917 |
| authorships[18].author.display_name | Stéphanie Gayral |
| authorships[18].countries | FR |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I154526488, https://openalex.org/I4210147779 |
| authorships[18].affiliations[0].raw_affiliation_string | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| authorships[18].institutions[0].id | https://openalex.org/I154526488 |
| authorships[18].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[18].institutions[0].type | government |
| authorships[18].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[18].institutions[0].country_code | FR |
| authorships[18].institutions[0].display_name | Inserm |
| authorships[18].institutions[1].id | https://openalex.org/I4210147779 |
| authorships[18].institutions[1].ror | https://ror.org/04d73z393 |
| authorships[18].institutions[1].type | facility |
| authorships[18].institutions[1].lineage | https://openalex.org/I134560555, https://openalex.org/I154526488, https://openalex.org/I4210147779, https://openalex.org/I4412460029 |
| authorships[18].institutions[1].country_code | FR |
| authorships[18].institutions[1].display_name | Institut des Maladies Métaboliques et Cardiovasculaires |
| authorships[18].author_position | last |
| authorships[18].raw_author_name | Stephanie Gayral |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut national de la Santé et de la Recherche (INSERM) 1297, University of Toulouse 3, France (M.N., A.F., A.L., N.M., A.D., R.Z., A.S., A.W., J.V., A.N.-S., D.R., M.L., S.G.). |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://hal.science/hal-04520255 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10587 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Autophagy in Disease and Therapy |
| related_works | https://openalex.org/W3150996080, https://openalex.org/W214686084, https://openalex.org/W2001675597, https://openalex.org/W2390710048, https://openalex.org/W1986011996, https://openalex.org/W2999142289, https://openalex.org/W2517018060, https://openalex.org/W2903290256, https://openalex.org/W4211180001, https://openalex.org/W2913409922 |
| cited_by_count | 8 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 6 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:HAL:hal-04520255v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402512 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| best_oa_location.source.host_organization | https://openalex.org/I1294671590 |
| best_oa_location.source.host_organization_name | Centre National de la Recherche Scientifique |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1294671590 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Journal articles |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Arteriosclerosis, Thrombosis, and Vascular Biology, 2024, 44 (3), pp.620-634. ⟨10.1161/ATVBAHA.123.319978⟩ |
| best_oa_location.landing_page_url | https://hal.science/hal-04520255 |
| primary_location.id | doi:10.1161/atvbaha.123.319978 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S3485792 |
| primary_location.source.issn | 1079-5642, 1524-4636 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1079-5642 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Arteriosclerosis Thrombosis and Vascular Biology |
| primary_location.source.host_organization | https://openalex.org/P4310315671 |
| primary_location.source.host_organization_name | Lippincott Williams & Wilkins |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315671 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Arteriosclerosis, Thrombosis, and Vascular Biology |
| primary_location.landing_page_url | https://doi.org/10.1161/atvbaha.123.319978 |
| publication_date | 2023-12-28 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2966654380, https://openalex.org/W2275204317, https://openalex.org/W2084621368, https://openalex.org/W3195247524, https://openalex.org/W2109034822, https://openalex.org/W1968444524, https://openalex.org/W2089230333, https://openalex.org/W1994823455, https://openalex.org/W2565318436, https://openalex.org/W2745425348, https://openalex.org/W1990138203, https://openalex.org/W2727058701, https://openalex.org/W2207791419, https://openalex.org/W2179361784, https://openalex.org/W2761789568, https://openalex.org/W1572032866, https://openalex.org/W2173450677, https://openalex.org/W2790526907, https://openalex.org/W3000175340, https://openalex.org/W2063145866, https://openalex.org/W2150782716, https://openalex.org/W2239521416, https://openalex.org/W1825060430, https://openalex.org/W2945654734, https://openalex.org/W1974279922, https://openalex.org/W2113892331, https://openalex.org/W2913155102, https://openalex.org/W1524785967, https://openalex.org/W1979237890, https://openalex.org/W2059348339, https://openalex.org/W2754367256, https://openalex.org/W2166219550, https://openalex.org/W2015224519, https://openalex.org/W2045616300, https://openalex.org/W1978201430, https://openalex.org/W2108972925, https://openalex.org/W994781960, https://openalex.org/W2028707469, https://openalex.org/W1990450608, https://openalex.org/W2911928150, https://openalex.org/W2116660526, https://openalex.org/W2158711047, https://openalex.org/W2790064807, https://openalex.org/W3007427066, https://openalex.org/W2942368772, https://openalex.org/W1580381879, https://openalex.org/W4288459132, https://openalex.org/W1988850210, https://openalex.org/W2135503869, https://openalex.org/W116871394 |
| referenced_works_count | 50 |
| abstract_inverted_index.) | 167 |
| abstract_inverted_index.a | 9, 38, 273 |
| abstract_inverted_index.1) | 193 |
| abstract_inverted_index.EC | 42, 75, 170, 240, 253, 268, 281 |
| abstract_inverted_index.II | 147, 152 |
| abstract_inverted_index.In | 32 |
| abstract_inverted_index.We | 105 |
| abstract_inverted_index.be | 247 |
| abstract_inverted_index.by | 114, 141 |
| abstract_inverted_index.in | 64, 94, 123, 159, 177, 199, 208, 226, 239, 283 |
| abstract_inverted_index.is | 8, 19, 47 |
| abstract_inverted_index.it | 46 |
| abstract_inverted_index.of | 127, 145, 190, 217, 233, 276 |
| abstract_inverted_index.on | 41, 74, 80, 101 |
| abstract_inverted_index.or | 59, 99 |
| abstract_inverted_index.to | 3, 5, 22, 71, 97, 169, 220, 228, 279 |
| abstract_inverted_index.we | 86, 182, 213 |
| abstract_inverted_index.α | 143, 153 |
| abstract_inverted_index.34) | 138 |
| abstract_inverted_index.HSS | 36, 53, 100, 110 |
| abstract_inverted_index.III | 130 |
| abstract_inverted_index.LSS | 34, 51, 98, 108, 179, 210, 229, 284 |
| abstract_inverted_index.Our | 256 |
| abstract_inverted_index.The | 1 |
| abstract_inverted_index.and | 27, 35, 52, 76, 90, 109, 195, 230, 252, 271 |
| abstract_inverted_index.but | 139 |
| abstract_inverted_index.for | 12 |
| abstract_inverted_index.led | 168, 219 |
| abstract_inverted_index.low | 23 |
| abstract_inverted_index.the | 88, 102, 128, 142, 178, 248, 264 |
| abstract_inverted_index.was | 125 |
| abstract_inverted_index.ApoE | 81, 160, 200 |
| abstract_inverted_index.ECs. | 65 |
| abstract_inverted_index.PI3K | 131, 148 |
| abstract_inverted_index.axis | 278 |
| abstract_inverted_index.cell | 15 |
| abstract_inverted_index.data | 257 |
| abstract_inverted_index.flow | 69 |
| abstract_inverted_index.have | 37 |
| abstract_inverted_index.high | 28 |
| abstract_inverted_index.mice | 83, 162, 204 |
| abstract_inverted_index.role | 275 |
| abstract_inverted_index.that | 107, 184, 196, 215, 231, 243, 259 |
| abstract_inverted_index.this | 244 |
| abstract_inverted_index.tune | 55 |
| abstract_inverted_index.with | 173 |
| abstract_inverted_index.(ApoE | 163 |
| abstract_inverted_index.(ECs) | 16 |
| abstract_inverted_index.(LSS) | 26 |
| abstract_inverted_index.+/− | 166, 203 |
| abstract_inverted_index.Using | 67 |
| abstract_inverted_index.VPS34 | 134 |
| abstract_inverted_index.basic | 10 |
| abstract_inverted_index.class | 129, 146, 151 |
| abstract_inverted_index.could | 246 |
| abstract_inverted_index.fluid | 68 |
| abstract_inverted_index.found | 106 |
| abstract_inverted_index.shear | 24, 29 |
| abstract_inverted_index.still | 48 |
| abstract_inverted_index.which | 18 |
| abstract_inverted_index.whole | 84 |
| abstract_inverted_index.(HSS). | 31 |
| abstract_inverted_index.cilium | 224, 235 |
| abstract_inverted_index.forces | 7, 73, 261 |
| abstract_inverted_index.impact | 40 |
| abstract_inverted_index.mTORC1 | 187 |
| abstract_inverted_index.mimics | 236 |
| abstract_inverted_index.plaque | 175 |
| abstract_inverted_index.rescue | 206 |
| abstract_inverted_index.reveal | 258 |
| abstract_inverted_index.stress | 25, 30 |
| abstract_inverted_index.system | 70, 266 |
| abstract_inverted_index.target | 189 |
| abstract_inverted_index.unique | 56 |
| abstract_inverted_index.within | 263 |
| abstract_inverted_index.Indeed, | 120 |
| abstract_inverted_index.ability | 2 |
| abstract_inverted_index.absence | 216 |
| abstract_inverted_index.central | 274 |
| abstract_inverted_index.complex | 192 |
| abstract_inverted_index.imaging | 78 |
| abstract_inverted_index.isoform | 144 |
| abstract_inverted_index.linking | 250 |
| abstract_inverted_index.prevent | 280 |
| abstract_inverted_index.primary | 223, 234 |
| abstract_inverted_index.protein | 137 |
| abstract_inverted_index.reduced | 156 |
| abstract_inverted_index.respond | 4 |
| abstract_inverted_index.sorting | 136 |
| abstract_inverted_index.studied | 87 |
| abstract_inverted_index.trigger | 60, 111 |
| abstract_inverted_index.unclear | 49 |
| abstract_inverted_index.whether | 50 |
| abstract_inverted_index.−/− | 82, 161, 164, 201 |
| abstract_inverted_index.3-kinase | 150 |
| abstract_inverted_index.Finally, | 212 |
| abstract_inverted_index.However, | 45 |
| abstract_inverted_index.METHODS: | 66 |
| abstract_inverted_index.RESULTS: | 104 |
| abstract_inverted_index.ablation | 232 |
| abstract_inverted_index.analyses | 79 |
| abstract_inverted_index.arterial | 209, 265 |
| abstract_inverted_index.cellular | 89 |
| abstract_inverted_index.generate | 72 |
| abstract_inverted_index.inhibits | 186 |
| abstract_inverted_index.involved | 93 |
| abstract_inverted_index.modules. | 119 |
| abstract_inverted_index.regions. | 180, 211, 285 |
| abstract_inverted_index.response | 96, 227, 270 |
| abstract_inverted_index.revealed | 183 |
| abstract_inverted_index.specific | 61, 116 |
| abstract_inverted_index.supports | 272 |
| abstract_inverted_index.(vacuolar | 135 |
| abstract_inverted_index.3-kinase) | 133 |
| abstract_inverted_index.PI3KCIIα | 157, 165, 185, 202, 218, 251 |
| abstract_inverted_index.arteries, | 33, 85 |
| abstract_inverted_index.autophagy | 43, 112, 122, 207 |
| abstract_inverted_index.decreased | 221 |
| abstract_inverted_index.increased | 174 |
| abstract_inverted_index.machinery | 58 |
| abstract_inverted_index.mechanism | 92 |
| abstract_inverted_index.molecular | 91 |
| abstract_inverted_index.organelle | 245 |
| abstract_inverted_index.rapamycin | 191, 197 |
| abstract_inverted_index.responses | 63 |
| abstract_inverted_index.signaling | 118 |
| abstract_inverted_index.subjected | 21 |
| abstract_inverted_index.treatment | 198 |
| abstract_inverted_index.(mammalian | 188 |
| abstract_inverted_index.activation | 113, 194 |
| abstract_inverted_index.associated | 172 |
| abstract_inverted_index.autophagic | 57, 62, 95, 117, 269 |
| abstract_inverted_index.biogenesis | 225 |
| abstract_inverted_index.controlled | 140 |
| abstract_inverted_index.deposition | 176 |
| abstract_inverted_index.determines | 267 |
| abstract_inverted_index.expression | 158, 238 |
| abstract_inverted_index.mechanical | 6, 260 |
| abstract_inverted_index.mobilizing | 115 |
| abstract_inverted_index.multiscale | 77 |
| abstract_inverted_index.processes. | 44 |
| abstract_inverted_index.suggesting | 242 |
| abstract_inverted_index.BACKGROUND: | 0 |
| abstract_inverted_index.LSS-induced | 121 |
| abstract_inverted_index.differently | 54 |
| abstract_inverted_index.dysfunction | 282 |
| abstract_inverted_index.endothelial | 14, 222 |
| abstract_inverted_index.endothelium | 124 |
| abstract_inverted_index.independent | 126 |
| abstract_inverted_index.maintaining | 13 |
| abstract_inverted_index.requirement | 11 |
| abstract_inverted_index.variability | 262 |
| abstract_inverted_index.Accordingly, | 155 |
| abstract_inverted_index.CONCLUSIONS: | 255 |
| abstract_inverted_index.continuously | 20 |
| abstract_inverted_index.demonstrated | 214 |
| abstract_inverted_index.differential | 39 |
| abstract_inverted_index.dysfunction, | 241 |
| abstract_inverted_index.dysfunctions | 171 |
| abstract_inverted_index.endothelium. | 103 |
| abstract_inverted_index.homeostasis, | 17 |
| abstract_inverted_index.homeostasis. | 254 |
| abstract_inverted_index.specifically | 205 |
| abstract_inverted_index.[PI3KCIIα]). | 154 |
| abstract_inverted_index.mechanosensor | 249 |
| abstract_inverted_index.Mechanistically, | 181 |
| abstract_inverted_index.PI3KCIIα/mTORC1 | 277 |
| abstract_inverted_index.(phosphoinositide | 132, 149 |
| abstract_inverted_index.PI3KCIIα-decreased | 237 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 19 |
| citation_normalized_percentile.value | 0.88213682 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |