PIEZO2‐dependent rapid pain system in humans and mice Article Swipe
Otmane Bouchatta
,
Marek Brodzki
,
Houria Manouze
,
Gabriela B. Carballo
,
Emma Kindström
,
Felipe Meira de‐Faria
,
Huasheng Yu
,
Anika R. Kao
,
Oumie Thorell
,
Jaquette Liljencrantz
,
Kevin K. W. Ng
,
Eleni Frangos
,
Bengt Ragnemalm
,
Dimah Saade
,
Diana Bharucha‐Goebel
,
Ilona Szczot
,
Warren Moore
,
Katarzyna Terejko
,
Jonathan Cole
,
Carsten G. Bönnemann
,
Wenquin Luo
,
David A. Mahns
,
Max Larsson
,
Gregory J. Gerling
,
Andrew Marshall
,
Alexander T. Chesler
,
Håkan Olausson
,
Saad S. Nagi
,
Marcin Szczot
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.01.569650
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.01.569650
Summary The PIEZO2 ion channel is critical for transducing light touch into neural signals but is not considered necessary for transducing acute pain in humans. Here, we discovered an exception – a form of mechanical pain evoked by hair pulling. Based on observations in a rare group of individuals with PIEZO2 deficiency syndrome, we demonstrated that hair-pull pain is dependent on PIEZO2 transduction. Studies in control participants showed that hair-pull pain triggered a distinct nocifensive response, including a nociceptive reflex. Observations in rare Aβ deafferented individuals and nerve conduction block studies in control participants revealed that hair-pull pain perception is dependent on Aβ input. Single-unit axonal recordings revealed that a class of cooling-responsive myelinated nociceptors in human skin is selectively tuned to painful hair-pull stimuli. Further, we pharmacologically mapped these nociceptors to a specific transcriptomic class. Finally, using functional imaging in mice, we demonstrated that in a homologous nociceptor, Piezo2 is necessary for high-sensitivity, robust activation by hair-pull stimuli. Together, we have demonstrated that hair-pulling evokes a distinct type of pain with conserved behavioral, neural, and molecular features across humans and mice.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.12.01.569650
- https://www.biorxiv.org/content/biorxiv/early/2023/12/02/2023.12.01.569650.full.pdf
- OA Status
- green
- Cited By
- 9
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389271555
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389271555Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.12.01.569650Digital Object Identifier
- Title
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PIEZO2‐dependent rapid pain system in humans and miceWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-02Full publication date if available
- Authors
-
Otmane Bouchatta, Marek Brodzki, Houria Manouze, Gabriela B. Carballo, Emma Kindström, Felipe Meira de‐Faria, Huasheng Yu, Anika R. Kao, Oumie Thorell, Jaquette Liljencrantz, Kevin K. W. Ng, Eleni Frangos, Bengt Ragnemalm, Dimah Saade, Diana Bharucha‐Goebel, Ilona Szczot, Warren Moore, Katarzyna Terejko, Jonathan Cole, Carsten G. Bönnemann, Wenquin Luo, David A. Mahns, Max Larsson, Gregory J. Gerling, Andrew Marshall, Alexander T. Chesler, Håkan Olausson, Saad S. Nagi, Marcin SzczotList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.12.01.569650Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/12/02/2023.12.01.569650.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/12/02/2023.12.01.569650.full.pdfDirect OA link when available
- Concepts
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Nociceptor, Nociception, Neuroscience, Transduction (biophysics), Reflex, Medicine, Perception, Psychology, Biology, Receptor, Internal medicine, BiophysicsTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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