Plasma Betatrophin Levels and Carotid Atherosclerosis Article Swipe
Hanako Niki
,
Yoshimi Kishimoto
,
Emi Saita
,
Reiko Ohmori
,
Kazuo Kondo
,
Yukihiko Momiyama
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1155/2019/4214650
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1155/2019/4214650
Aims. Betatrophin is a recently identified circulating adipokine that may affect lipid and glucose metabolism. However, the association between plasma betatrophin levels and carotid atherosclerosis has not been elucidated. Methods. We investigated plasma betatrophin levels in 153 subjects undergoing carotid ultrasonography. The severity of plaque was evaluated as plaque score. Results. Of the 153 subjects, plaque was found in 63 (41%). Plasma betatrophin levels were higher in 63 subjects with plaque than in 90 without plaque (median 906 vs. 729 pg/mL, ). A stepwise increase in betatrophin levels was found depending on the plaque score: 729 pg/mL in (), 802 pg/mL in (), and 978 pg/mL in () (). In particular, betatrophin levels in subjects with were higher than in those with (). Moreover, betatrophin levels correlated with plaque score (, ), but no significant correlation was found between betatrophin levels and triglyceride or HbA1c levels. The percentage of subjects with was higher in subjects with plaque than in those without plaque (65% vs. 44%) and was highest in (78%) (). In the multivariate analysis, betatrophin level was not a significant factor for the presence of plaque but was a significant factor for plaque , independent of atherosclerotic risk factors. The odds ratio for was 4.9 (95% -12.8) for . Conclusions. Plasma betatrophin levels were found to be high in subjects with carotid plaque and to be associated with the severity of plaque. Betatrophin may play a role in the progression of carotid atherosclerosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2019/4214650
- https://downloads.hindawi.com/journals/dm/2019/4214650.pdf
- OA Status
- hybrid
- Cited By
- 7
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2980398988
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2980398988Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/2019/4214650Digital Object Identifier
- Title
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Plasma Betatrophin Levels and Carotid AtherosclerosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-10-17Full publication date if available
- Authors
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Hanako Niki, Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko MomiyamaList of authors in order
- Landing page
-
https://doi.org/10.1155/2019/4214650Publisher landing page
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https://downloads.hindawi.com/journals/dm/2019/4214650.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://downloads.hindawi.com/journals/dm/2019/4214650.pdfDirect OA link when available
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Internal medicine, Medicine, Cardiology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 1, 2024: 1, 2021: 4, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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