Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition Decline Article Swipe
Lifang Wang
,
Hefu Zhen
,
Yuzhe Sun
,
Shuang Rong
,
Benchao Li
,
Zhijie Song
,
Zhili Liu
,
Ruidong Guo
,
Zhiming Li
,
Jiahong Ding
,
Huanming Yang
,
Xun Xu
,
Xiuqing Zhang
,
Hai‐Xi Sun
,
Chao Nie
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1052464/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1052464/v1
Numerous studies have investigated the risk factors of Alzheimer’s disease (AD), however, AD- risk factors related miRNAs were rarely reported. In this study, AD- risk factor related miRNAs of 119 Chinese individuals (47 AD patients and 62 cognitively normal controls) were investigated. The results showed that education, tea consumption, leisure activity, and social connection were low Body Mass Index (BMI), depression, and smoking were potentially risk factors for AD patients. Moreover, we screened exosome microRNAs (miRNAs) for the aforementioned lifestyle-related factors. Canonical correlation analyses revealed that our clinical observations were correlated with the miRNA expression profile for education, depression, leisure activity, and social connection. Furthermore, we predicted the targets of differentially expressed miRNAs and found that many of them were reported to be involved in the generation and clearance of Amyloid-beta (Aβ), important molecules related to cognition, and disease-activated microglia response to AD. Our results indicated that certain education and depression factors can contribute to AD progression by modulating miRNA expression, implying that preventive interventions might alter AD progression in Chinese patients.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1052464/v1
- https://www.researchsquare.com/article/rs-1052464/latest.pdf
- OA Status
- green
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3214750600
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3214750600Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-1052464/v1Digital Object Identifier
- Title
-
Plasma Exo-miRNAs Correlated with AD-Related Factors of Chinese Individuals Involved in Aβ Accumulation and Cognition DeclineWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-11-18Full publication date if available
- Authors
-
Lifang Wang, Hefu Zhen, Yuzhe Sun, Shuang Rong, Benchao Li, Zhijie Song, Zhili Liu, Ruidong Guo, Zhiming Li, Jiahong Ding, Huanming Yang, Xun Xu, Xiuqing Zhang, Hai‐Xi Sun, Chao NieList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-1052464/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-1052464/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-1052464/latest.pdfDirect OA link when available
- Concepts
-
Cognition, microRNA, Psychology, Cognitive decline, Developmental psychology, Biology, Neuroscience, Medicine, Genetics, Dementia, Internal medicine, Gene, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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71Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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