Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS Article Swipe
Moemen Eltobgy
,
Brett Klamer
,
Daniela Farkas
,
J.D. Londino
,
Joshua A. Englert
,
Jeffrey C. Horowitz
,
Rama K. Mallampalli
,
Guy Brock
,
Joseph S. Bednash
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.70300
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.70300
Severe COVID‐19 is often complicated by hypoxemic respiratory failure and acute respiratory distress syndrome (ARDS). Mechanisms governing lung injury and repair in ARDS remain poorly understood. We hypothesized that plasma proteomics may uncover protein biomarkers correlated with COVID‐19 ARDS severity. We analyzed the plasma proteome from 32 patients with ARDS and COVID‐19 using an aptamer‐based platform of 7289 proteins, and correlated protein measurements with sequential organ failure assessment (SOFA) scores at days 1 and 7 of ICU admission. We identified 184 differentially abundant proteins correlated with SOFA at day 1 and 46 proteins at day 7. In a longitudinal analysis, we correlated dynamic changes in protein abundance and SOFA between days 1 and 7 and identified 40 significant proteins. Pathway analysis of significant proteins identified increased ephrin signaling and acute phase response signaling correlated with increased SOFA scores between days 1 and 7, while pathways related to pulmonary fibrosis signaling and wound healing had a negative correlation. These findings suggest that persistent inflammation may drive disease severity, while repair processes correlate with improvements in organ dysfunction. This approach is generalizable to future ARDS cohorts for identification of biomarkers and disease mechanisms as we strive towards targeted therapies in ARDS.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14814/phy2.70300
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.70300
- OA Status
- gold
- References
- 97
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409119042
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409119042Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.14814/phy2.70300Digital Object Identifier
- Title
-
Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDSWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-01Full publication date if available
- Authors
-
Moemen Eltobgy, Brett Klamer, Daniela Farkas, J.D. Londino, Joshua A. Englert, Jeffrey C. Horowitz, Rama K. Mallampalli, Guy Brock, Joseph S. BednashList of authors in order
- Landing page
-
https://doi.org/10.14814/phy2.70300Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.70300Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.70300Direct OA link when available
- Concepts
-
ARDS, Medicine, Proteome, Proteomics, SOFA score, Bioinformatics, Inflammation, Lung, Internal medicine, Sepsis, Biology, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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97Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.7, | 143 |
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| abstract_inverted_index.proteins. | 119 |
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