Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population Article Swipe
Charlie G.Y. Lim
,
Bige Özkan
,
Yujian Liang
,
Jingsha Chen
,
Jiali Yao
,
Nang Ei Ei Khaing
,
Mary R. Rooney
,
Chiadi E. Ndumele
,
E Shyong Tai
,
Josef Coresh
,
Xueling Sim
,
Rob M. van Dam
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2337/db24-0184
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2337/db24-0184
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to 1) evaluate the associations between BMI, waist circumference (WC), and ∼5,000 plasma proteins (SomaScan V4), 2) identify protein signatures of BMI and WC, and 3) evaluate the associations between the protein signatures and cardiometabolic health, including metabolically unhealthy obesity and type 2 diabetes incidence in the Singapore Multi-Ethnic Cohort Phase 1 (MEC1). Among 410 BMI-associated and 385 WC-associated proteins, we identified protein signatures of BMI and WC and validated them in an independent data set across two time points and externally in the Atherosclerosis Risk in Communities (ARIC) study. The BMI and WC protein signatures were highly correlated with total and visceral body fat, respectively. Furthermore, the protein signatures were significantly associated with cardiometabolic risk factors and metabolically unhealthy obesity. In prospective analyses, the protein signatures were strongly associated with type 2 diabetes risk in MEC1 (odds ratio per SD increment in WC protein signature 2.84; 95% CI 2.47–3.25) and ARIC (hazard ratio 1.98; 95% CI 1.88–2.08). Our protein signatures have potential uses in the monitoring of metabolically unhealthy obesity. Article Highlights We evaluated the associations between ∼5,000 plasma proteins and BMI and waist circumference (WC) in a multiethnic Asian population. We identified 410 proteins associated with BMI and 385 proteins associated with WC and derived protein signatures of BMI and WC, which we validated externally in a U.S. cohort. Both the BMI and WC protein signatures were strongly associated with cardiometabolic risk factors, metabolically unhealthy obesity, and risk of obesity, metabolic syndrome, and type 2 diabetes. Our protein signatures have potential uses in monitoring metabolically unhealthy obesity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2337/db24-0184
- https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db24-0184/791098/db240184.pdf
- OA Status
- bronze
- Cited By
- 2
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404906629
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4404906629Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2337/db24-0184Digital Object Identifier
- Title
-
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian PopulationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-02Full publication date if available
- Authors
-
Charlie G.Y. Lim, Bige Özkan, Yujian Liang, Jingsha Chen, Jiali Yao, Nang Ei Ei Khaing, Mary R. Rooney, Chiadi E. Ndumele, E Shyong Tai, Josef Coresh, Xueling Sim, Rob M. van DamList of authors in order
- Landing page
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https://doi.org/10.2337/db24-0184Publisher landing page
- PDF URL
-
https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db24-0184/791098/db240184.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db24-0184/791098/db240184.pdfDirect OA link when available
- Concepts
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Medicine, Body mass index, Type 2 diabetes, Waist, Obesity, Internal medicine, Hazard ratio, Diabetes mellitus, Odds ratio, Population, Cohort, Endocrinology, Confidence interval, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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