Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies Article Swipe

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Hannah F. Bradford , Christophe J. Lalaurie , Jayesh Gor , Xin Gao , Charis Pericleous , Stephen J. Perkins , Hannah M. Britt , Konstantinos Thalassinos , Ian Giles , Anisur Rahman , Mihaela Delcea , Paul A. Dalby , Thomas McDonnell ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.jtha.2025.02.015

Cleavage of β2GPI by plasmin results in the production of a unique S-shaped structural conformation and higher patient antibody binding. This novel structure may increase the production of antibodies and explain the loss of binding to phospholipids described previously for plasmin-clipped β2GPI.

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Plasmin Glycoprotein Antibody Chemistry Cleavage (geology) BETA (programming language) Biochemistry Molecular biology Cell biology Immunology Medicine Biology Computer science Enzyme Fracture (geology) Paleontology Programming language

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.jtha.2025.02.015
OA Status: hybrid
Cited By: 1
References: 54
Related Works: 10
OpenAlex ID: https://openalex.org/W4407870505

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DOI: https://doi.org/10.1016/j.jtha.2025.02.015

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Title: Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies

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Language: en

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Publication year: 2025

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Publication date: 2025-02-24

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Authors: Hannah F. Bradford, Christophe J. Lalaurie, Jayesh Gor, Xin Gao, Charis Pericleous, Stephen J. Perkins, Hannah M. Britt, Konstantinos Thalassinos, Ian Giles, Anisur Rahman, Mihaela Delcea, Paul A. Dalby, Thomas McDonnell

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Landing page: https://doi.org/10.1016/j.jtha.2025.02.015

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Concepts: Plasmin, Glycoprotein, Antibody, Chemistry, Cleavage (geology), BETA (programming language), Biochemistry, Molecular biology, Cell biology, Immunology, Medicine, Biology, Computer science, Enzyme, Fracture (geology), Paleontology, Programming language

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Cited by: 1

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