Platelet, a key regulator of innate and adaptive immunity Article Swipe
Cheng Yan
,
Haojie Wu
,
Xianchun Fang
,
Junji He
,
Feng Zhu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2023.1074878
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2023.1074878
Platelets, anucleate blood components, represent the major cell type involved in the regulation of hemostasis and thrombosis. In addition to performing haemostatic roles, platelets can influence both innate and adaptive immune responses. In this review, we summarize the development of platelets and their functions in hemostasis. We also discuss the interactions between platelet products and innate or adaptive immune cells, including neutrophils, monocytes, macrophages, T cells, B cells and dendritic cells. Activated platelets and released molecules regulate the differentiation and function of these cells via platelet-derived receptors or secreting molecules. Platelets have dual effects on nearly all immune cells. Understanding the exact mechanisms underlying these effects will enable further application of platelet transfusion.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmed.2023.1074878
- https://www.frontiersin.org/articles/10.3389/fmed.2023.1074878/pdf
- OA Status
- gold
- Cited By
- 24
- References
- 166
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323857493
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4323857493Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmed.2023.1074878Digital Object Identifier
- Title
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Platelet, a key regulator of innate and adaptive immunityWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-10Full publication date if available
- Authors
-
Cheng Yan, Haojie Wu, Xianchun Fang, Junji He, Feng ZhuList of authors in order
- Landing page
-
https://doi.org/10.3389/fmed.2023.1074878Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmed.2023.1074878/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmed.2023.1074878/pdfDirect OA link when available
- Concepts
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Platelet, Innate immune system, Hemostasis, Acquired immune system, Cell biology, Immune system, Immunology, Regulator, Biology, Receptor, Platelet activation, Medicine, Internal medicine, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
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2025: 11, 2024: 11, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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166Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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