Platelet bioenergetics correlate with skeletal muscle respiration in a murine model of type II diabetes Article Swipe
Mia S. Wilkinson
,
Emily J. Ferguson
,
Justin Bureau
,
Roan A. L. Haggerty-Goede
,
Dalia M. Miller
,
Michelle Kuriakose
,
Jennifer L. M. H. Veeneman
,
Patricia D.A. Lima
,
Patricia D.A. Lima
,
Chris McGlory
,
Chris McGlory
,
Kimberly J. Dunham‐Snary
,
Kimberly J. Dunham‐Snary
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2025.1639882
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2025.1639882
Mitochondrial bioenergetic research in skeletal muscle is limited by the need for biopsies. We executed a proof-of-concept study to evaluate whether blood platelets could serve as a minimally invasive surrogate for skeletal muscle mitochondrial respiration in mice. Using Seahorse extracellular flux analysis, platelet respiration was measured in healthy C57BL/6J and leptin receptor-null db/db mice, while high-resolution respirometry (Oroboros O2k) assessed mitochondrial function in white gastrocnemius muscle of the same animals. A critical component of this study was extensive methodological optimization for platelet bioenergetics analysis in mice. We provide comprehensive methodological details and guiding principles for performing Seahorse bioenergetic assays on mouse platelets. Our foundational findings also suggest platelet mitochondria can reflect tissue-level mitochondrial health, pointing to a potential “liquid biopsy” approach for assessing metabolic status. Multiple key metrics of respiration showed significant correlations between platelets and muscle in the same animals, indicating that platelet bioenergetic profiles mirror the metabolic status of skeletal muscle in healthy and genetically diabetic mice. This work lays the conceptual and methodological foundation for future studies in human metabolic diseases where muscle bioenergetic dysfunction is implicated but current methods are not implementable for clinical surveillance. This study provides foundational proof-of-concept in healthy and diabetic mice, motivating validation in human studies as the next step toward biomarker development and precision medicine strategies.
Related Topics
Concepts
Bioenergetics
Skeletal muscle
Mitochondrion
Platelet
Biology
Endocrinology
Internal medicine
Respiration
Oxidative phosphorylation
Respirometry
Flux (metallurgy)
Biomarker
Cellular respiration
Gastrocnemius muscle
Diabetes mellitus
Energy metabolism
Type 2 diabetes
Sarcopenia
Leptin
Metabolome
Extracellular
Glycolysis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2025.1639882
- https://public-pages-files-2025.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1639882/pdf
- OA Status
- gold
- References
- 83
- OpenAlex ID
- https://openalex.org/W7105685866
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7105685866Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fmolb.2025.1639882Digital Object Identifier
- Title
-
Platelet bioenergetics correlate with skeletal muscle respiration in a murine model of type II diabetesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-14Full publication date if available
- Authors
-
Mia S. Wilkinson, Emily J. Ferguson, Justin Bureau, Roan A. L. Haggerty-Goede, Dalia M. Miller, Michelle Kuriakose, Jennifer L. M. H. Veeneman, Patricia D.A. Lima, Patricia D.A. Lima, Chris McGlory, Chris McGlory, Kimberly J. Dunham‐Snary, Kimberly J. Dunham‐SnaryList of authors in order
- Landing page
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https://doi.org/10.3389/fmolb.2025.1639882Publisher landing page
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https://public-pages-files-2025.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1639882/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://public-pages-files-2025.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1639882/pdfDirect OA link when available
- Concepts
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Bioenergetics, Skeletal muscle, Mitochondrion, Platelet, Biology, Endocrinology, Internal medicine, Respiration, Oxidative phosphorylation, Respirometry, Flux (metallurgy), Biomarker, Cellular respiration, Gastrocnemius muscle, Diabetes mellitus, Energy metabolism, Type 2 diabetes, Sarcopenia, Leptin, Metabolome, Extracellular, GlycolysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
83Number of works referenced by this work
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