Platelet Quiescence in Patients With Acute Coronary Syndrome Undergoing Coronary Artery Bypass Graft Surgery Article Swipe
Kiran Sarathy
,
George A. Wells
,
Kuljit Singh
,
Étienne Couture
,
Aun‐Yeong Chong
,
Fraser D. Rubens
,
Marie Lordkipanidzé
,
Jean‐François Tanguay
,
Derek So
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.120.016602
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.120.016602
Background The optimal antiplatelet strategy for patients with acute coronary syndromes who require coronary artery bypass surgery remains unclear. While a more potent antiplatelet regimen will predispose to perioperative bleeding, it is hypothesized that through “platelet quiescence,” ischemic protection conferred by such therapy may provide a net clinical benefit. Methods and Results We compared patients undergoing coronary artery bypass surgery who were treated with a more potent antiplatelet inhibition strategy with those with a less potent inhibition through a meta‐analysis. The primary outcome was all‐cause mortality after bypass surgery. The analysis identified 4 studies in which the antiplatelet regimen was randomized and 6 studies that were nonrandomized. Combining all studies, there was an overall higher mortality with weaker strategies compared with more potent strategies (odds ratio, 1.38; 95% CI, 1.03–1.85; P =0.03). Conclusions Our findings support the concept of platelet quiescence, in reducing mortality for patients with acute coronary syndrome requiring coronary artery bypass surgery. This suggests the routine up‐front use of potent antiplatelet regimens in acute coronary syndrome, irrespective of likelihood of coronary artery bypass graft.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1161/jaha.120.016602
- https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.016602
- OA Status
- gold
- Cited By
- 2
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3129578382
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3129578382Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/jaha.120.016602Digital Object Identifier
- Title
-
Platelet Quiescence in Patients With Acute Coronary Syndrome Undergoing Coronary Artery Bypass Graft SurgeryWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-18Full publication date if available
- Authors
-
Kiran Sarathy, George A. Wells, Kuljit Singh, Étienne Couture, Aun‐Yeong Chong, Fraser D. Rubens, Marie Lordkipanidzé, Jean‐François Tanguay, Derek SoList of authors in order
- Landing page
-
https://doi.org/10.1161/jaha.120.016602Publisher landing page
- PDF URL
-
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.016602Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.016602Direct OA link when available
- Concepts
-
Medicine, Acute coronary syndrome, Perioperative, Coronary artery bypass surgery, Internal medicine, Cardiology, Artery, Regimen, Myocardial infarction, Bypass surgery, Platelet aggregation inhibitor, Odds ratio, Platelet, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
12Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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