Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub‐study of the PLOT‐ICU cohort
Article Swipe
Carl Thomas Anthon
,
Frédéric Pène
,
Anders Perner
,
Élie Azoulay
,
Kathryn Puxty
,
Andry Van De Louw
,
Sanjay Chawla
,
Pedro Castro
,
Pedro Póvoa
,
Luís Coelho
,
Victoria Metaxa
,
Matthias Kochanek
,
Tobias Liebregts
,
Thomas Kander
,
Mirka Sivula
,
Morten Hylander Møller
,
Lene Russell
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/aas.14365
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/aas.14365
Introduction Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia. Methods This is a protocol and statistical analysis plan for a post hoc sub‐study of 504 thrombocytopenic patients from the ‘Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT‐ICU)’. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis‐derived versus pooled whole‐blood‐derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight‐based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell‐ and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow‐up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively. Conclusions The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT‐ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/aas.14365
- OA Status
- green
- Cited By
- 1
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390012924
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390012924Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/aas.14365Digital Object Identifier
- Title
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Platelet transfusions in adult thrombocytopenic
ICU patients: Protocol for a sub‐study of thePLOT‐ICU cohortWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-12-19Full publication date if available
- Authors
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Carl Thomas Anthon, Frédéric Pène, Anders Perner, Élie Azoulay, Kathryn Puxty, Andry Van De Louw, Sanjay Chawla, Pedro Castro, Pedro Póvoa, Luís Coelho, Victoria Metaxa, Matthias Kochanek, Tobias Liebregts, Thomas Kander, Mirka Sivula, Morten Hylander Møller, Lene RussellList of authors in order
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https://doi.org/10.1111/aas.14365Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/11638841Direct OA link when available
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Medicine, Platelet, Platelet transfusion, Cohort, Emergency medicine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.‘Thrombocytopenia | 58 |
| abstract_inverted_index.(apheresis‐derived | 94 |
| abstract_inverted_index.whole‐blood‐derived | 97 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5019245976 |
| countries_distinct_count | 9 |
| institutions_distinct_count | 17 |
| corresponding_institution_ids | https://openalex.org/I2802567020, https://openalex.org/I2802709434 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.41510751 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |