Pneumococcal Carriage in Infants Post-PCV10 Introduction in Pakistan: Results from Serial Cross-Sectional Surveys Article Swipe
YOU?
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· 2022
· Open Access
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· DOI: https://doi.org/10.20944/preprints202205.0321.v1
The 10-valent pneumococcal vaccine was introduced in Pakistan’s Expanded Program on Immunization (EPI) in 2013 as a 3+0 schedule without catchup. We conducted three annual cross-sectional surveys from 2014-2016 to measure vaccine-type (VT) carriage in infants from a rural part of Pakistan. Nasopharyngeal specimens were collected by random sampling of infants from 2 union councils of Matiari. Samples were then transported to Infectious Disease Research Laboratory (IDRL) at the Aga Khan University within 6-8 hours of collection. Serotypes were established using sequential multiplex PCR. Of the 665 children enrolled across three surveys, 547 were culture positive for pneumococcus. VT carriage decreased from 21·8% in 2014 to 12·7% in 2016 (p-value for trend <0·001). Those who were not vaccinated or partially vaccinated were found to be at higher risk of carrying a VT serotype (aOR 2·53, 95% CI 1·39, 4·63 for non-vaccinated) and (aOR 3·35, 95% CI 1·82, 6·16 for partially vaccinated). On the other hand, being enrolled in the most recent survey was negatively associated with VT-carriage (aOR 0·51, 95% CI 0·28, 0·93). We found that PCV10 was effective in decreasing the carriage of vaccine-type serotypes in Pakistani infants.
Related Topics
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202205.0321.v1
- https://www.preprints.org/manuscript/202205.0321/v1/download
- OA Status
- green
- Cited By
- 2
- References
- 29
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4293062318Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.20944/preprints202205.0321.v1Digital Object Identifier
- Title
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Pneumococcal Carriage in Infants Post-PCV10 Introduction in Pakistan: Results from Serial Cross-Sectional SurveysWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-24Full publication date if available
- Authors
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Amala Khan, Shahira Shahid, Muhammad Imran Nisar, Farah Khalid, Muhammad Farrukh Qazi, Sheraz Ahmed, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Asad Ali, Cynthia G. Whitney, Anita K. M. Zaidi, Fyezah JehanList of authors in order
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https://doi.org/10.20944/preprints202205.0321.v1Publisher landing page
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https://www.preprints.org/manuscript/202205.0321/v1/downloadDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.preprints.org/manuscript/202205.0321/v1/downloadDirect OA link when available
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Carriage, Serotype, Medicine, Cross-sectional study, Internal medicine, Pediatrics, Veterinary medicine, Virology, PathologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2024: 1, 2022: 1Per-year citation counts (last 5 years)
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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