Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2) Article Swipe

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Jason W. Ashley , William Hancock , Alex Nelson , Robert N. Bone , Hubert M. Tse , Mary Wohltmann , John Turk , Sasanka Ramanadham ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1074/jbc.m116.754945

Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways. Activation of group VIA phospholipase A₂ (iPLA₂β) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote inflammation and pathologic states. We examined the role of iPLA₂β in peritoneal macrophage immune function by comparing wild type (WT) and iPLA₂β^-/- mouse macrophages. Compared with WT, iPLA₂β^-/- macrophages exhibited reduced proinflammatory M1 markers when classically activated. In contrast, anti-inflammatory M2 markers were elevated under naïve conditions and induced to higher levels by alternative activation in iPLA₂β^-/- macrophages compared with WT. Induction of eicosanoid (12-lipoxygenase (12-LO) and cyclooxygenase 2 (COX2))- and reactive oxygen species (NADPH oxidase 4 (NOX4))-generating enzymes by classical activation pathways was also blunted in iPLA₂β^-/- macrophages compared with WT. The effects of inhibitors of iPLA₂β, COX2, or 12-LO to reduce M1 polarization were greater than those to enhance M2 polarization. Certain lipids (lysophosphatidylcholine, lysophosphatidic acid, and prostaglandin E₂) recapitulated M1 phenotype in iPLA₂β^-/- macrophages, but none tested promoted M2 phenotype. These findings suggest that (a) lipids generated by iPLA₂β and subsequently oxidized by cyclooxygenase and 12-LO favor macrophage inflammatory M1 polarization, and (b) the absence of iPLA₂β promotes macrophage M2 polarization. Reducing macrophage iPLA₂β activity and thereby attenuating macrophage M1 polarization might cause a shift from an inflammatory to a recovery/repair milieu.

Related Topics

Reactive Oxygen Species

Concepts

Lysophosphatidylcholine Macrophage polarization NADPH oxidase Proinflammatory cytokine Innate immune system Inflammation Cell biology Phospholipase A2 Macrophage Eicosanoid Lysophosphatidic acid M2 Macrophage Arachidonic acid Chemistry NOX4 Biology Reactive oxygen species Immune system Biochemistry Immunology Phosphatidylcholine Enzyme Phospholipid In vitro Receptor Membrane

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Type: article
Language: en
Landing Page: https://doi.org/10.1074/jbc.m116.754945
PDF: http://www.jbc.org/article/S0021925820356969/pdf
OA Status: hybrid
Cited By: 44
References: 82
Related Works: 10
OpenAlex ID: https://openalex.org/W2539750952

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OpenAlex ID: https://openalex.org/W2539750952

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DOI: https://doi.org/10.1074/jbc.m116.754945

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Title: Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)

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Type: article

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Language: en

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Publication year: 2016

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Publication date: 2016-09-21

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Authors: Jason W. Ashley, William Hancock, Alex Nelson, Robert N. Bone, Hubert M. Tse, Mary Wohltmann, John Turk, Sasanka Ramanadham

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Landing page: https://doi.org/10.1074/jbc.m116.754945

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PDF URL: https://www.jbc.org/article/S0021925820356969/pdf

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OA status: hybrid

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OA URL: https://www.jbc.org/article/S0021925820356969/pdf

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Concepts: Lysophosphatidylcholine, Macrophage polarization, NADPH oxidase, Proinflammatory cytokine, Innate immune system, Inflammation, Cell biology, Phospholipase A2, Macrophage, Eicosanoid, Lysophosphatidic acid, M2 Macrophage, Arachidonic acid, Chemistry, NOX4, Biology, Reactive oxygen species, Immune system, Biochemistry, Immunology, Phosphatidylcholine, Enzyme, Phospholipid, In vitro, Receptor, Membrane

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Cited by: 44

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Citations by year (recent): 2025: 2, 2024: 4, 2023: 8, 2022: 5, 2021: 4

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References (count): 82

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Related works (count): 10

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title	Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)
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