Journal of Biological Chemistry • Vol 291 • No 44
Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)
September 2016 • Jason W. Ashley, William Hancock, Alex Nelson, Robert N. Bone, Hubert M. Tse, Mary Wohltmann, John Turk, Sasanka Ramanadham
Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways. Activation of group VIA phospholipase A<sub>2</sub> (iPLA<sub>2</sub>β) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote inflammation and pathologic states. We examined the role of iPLA<sub>2</sub>β in peritoneal macrophage immune function by comparing wild type (…