Polydopamine-based Nanoadjuvants Promote a Positive Feedback Loop for Cancer Immunotherapy via Overcoming Photothermally Boosted T Cell Exhaustion Article Swipe
Xiao-Kai Chi
,
Hairui Zhang
,
Jingjing Gao
,
Jin Su
,
Yongzhong Du
,
Xiaoling Xu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.34133/bmr.0166
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.34133/bmr.0166
Immunogenic cell death, triggered by photothermal therapy or specific chemotherapy, strives to establish a positive feedback loop in cancer immunotherapy. This loop is characterized by the rapid release of antigens and adenosine triphosphate (ATP), ultimately leading to accelerated T cell infiltration. However, this loop is hindered by T cell exhaustion caused by adenosine originating from ATP and glucose deprivation in the immunosuppressive microenvironment. To overcome this challenge, we developed a pH-low insertion peptide-functionalized mesoporous-polydopamine-based nanoadjuvant that incorporates adenosine deaminase and doxorubicin (termed as PPMAD). PPMAD aimed to overcome T cell exhaustion by reducing adenosine consumption and providing an alternative carbon source for CD8 + T cell function during glucose starvation. First, PPMAD triggered the burst release of antigens and ATP through photothermal therapy and doxorubicin-induced immunogenic cell death, culminating in the expedited infiltration of T cells. Second, adenosine deaminase depleted adenosine, reducing immunosuppressive agents and generating abundant inosine, which served as an alternative carbon source for CD8 + T cells. By implementing this “reducing suppression and broadening sources” strategy, we successfully overcome T cell exhaustion, greatly enhancing the effectiveness of cancer immunotherapy both in vitro and in vivo. Our findings highlighted the positive feedback loop between on-demand photothermal therapy, chemotherapy immunotherapy, and achieving complete tumor response.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.34133/bmr.0166
- https://spj.science.org/doi/pdf/10.34133/bmr.0166
- OA Status
- gold
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408217225
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408217225Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.34133/bmr.0166Digital Object Identifier
- Title
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Polydopamine-based Nanoadjuvants Promote a Positive Feedback Loop for Cancer Immunotherapy via Overcoming Photothermally Boosted T Cell ExhaustionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
-
Xiao-Kai Chi, Hairui Zhang, Jingjing Gao, Jin Su, Yongzhong Du, Xiaoling XuList of authors in order
- Landing page
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https://doi.org/10.34133/bmr.0166Publisher landing page
- PDF URL
-
https://spj.science.org/doi/pdf/10.34133/bmr.0166Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://spj.science.org/doi/pdf/10.34133/bmr.0166Direct OA link when available
- Concepts
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Immunotherapy, Cancer immunotherapy, Positive feedback, Loop (graph theory), Feedback loop, Cancer research, Materials science, Cancer, Medicine, Internal medicine, Computer science, Engineering, Mathematics, Combinatorics, Computer security, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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