Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression Article Swipe
Marloes Grobben
,
Margreet Bakker
,
Angela I. Schriek
,
Lonneke Levels
,
Jeffrey C. Umotoy
,
Khadija Tejjani
,
Mariëlle J. van Breemen
,
Ryan N. Lin
,
Steven W. de Taeye
,
Gabriel Ozorowski
,
Neeltje A. Kootstra
,
Andrew B. Ward
,
Stephen J. Kent
,
P. Mark Hogarth
,
Bruce D. Wines
,
Rogier W. Sanders
,
Amy W. Chung
,
Marit J. van Gils
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.ppat.1012739
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.ppat.1012739
HIV-1 infection leads to chronic disease requiring life-long treatment and therefore alternative therapeutics, a cure and/or a protective vaccine are needed. Antibody-mediated effector functions could have a role in the fight against HIV-1. However, the properties underlying the potential beneficial effects of antibodies during HIV-1 infection are poorly understood. To identify a specific profile of antibody features associated with delayed disease progression, we studied antibody polyfunctionality during untreated HIV-1 infection in the well-documented Amsterdam Cohort Studies. Serum samples were analyzed from untreated individuals with HIV-1 at approximately 6 months (n = 166) and 3 years (n = 382) post-seroconversion (post-SC). A Luminex antibody Fc array was used to profile 15 different Fc features for serum antibodies against 20 different HIV-1 envelope glycoprotein antigens and the resulting data was also compared with data on neutralization breadth. We found that high HIV-1 specific IgG1 levels and low IgG2 and IgG4 levels at 3 years post-SC were associated with delayed disease progression. Moreover, delayed disease progression was associated with a broad and polyfunctional antibody response. Specifically, the capacity to interact with all Fc γ receptors (FcγRs) and C1q, and in particular with FcγRIIa, correlated positively with delayed disease progression. There were strong correlations between antibody Fc features and neutralization breadth and several antibody features that were associated with delayed disease progression were also associated with the development of broad and potent antibody neutralization. In summary, we identified a strong association between broad, polyfunctional antibodies and delayed disease progression. These findings contribute new information for the fight against HIV-1, especially for new antibody-based therapy and cure strategies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.ppat.1012739
- https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012739&type=printable
- OA Status
- gold
- Cited By
- 3
- References
- 95
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405281014
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405281014Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.ppat.1012739Digital Object Identifier
- Title
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Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progressionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-11Full publication date if available
- Authors
-
Marloes Grobben, Margreet Bakker, Angela I. Schriek, Lonneke Levels, Jeffrey C. Umotoy, Khadija Tejjani, Mariëlle J. van Breemen, Ryan N. Lin, Steven W. de Taeye, Gabriel Ozorowski, Neeltje A. Kootstra, Andrew B. Ward, Stephen J. Kent, P. Mark Hogarth, Bruce D. Wines, Rogier W. Sanders, Amy W. Chung, Marit J. van GilsList of authors in order
- Landing page
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https://doi.org/10.1371/journal.ppat.1012739Publisher landing page
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012739&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012739&type=printableDirect OA link when available
- Concepts
-
Antibody, Immunology, Seroconversion, Neutralization, Disease, Medicine, Immune system, Antigen, Virology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
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95Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.However, | 33 |
| abstract_inverted_index.Studies. | 75 |
| abstract_inverted_index.analyzed | 79 |
| abstract_inverted_index.antibody | 55, 64, 102, 170, 201, 209, 228 |
| abstract_inverted_index.antigens | 122 |
| abstract_inverted_index.breadth. | 134 |
| abstract_inverted_index.capacity | 174 |
| abstract_inverted_index.compared | 129 |
| abstract_inverted_index.effector | 22 |
| abstract_inverted_index.envelope | 120 |
| abstract_inverted_index.features | 56, 112, 203, 210 |
| abstract_inverted_index.findings | 246 |
| abstract_inverted_index.identify | 50 |
| abstract_inverted_index.interact | 176 |
| abstract_inverted_index.specific | 52, 140 |
| abstract_inverted_index.summary, | 231 |
| abstract_inverted_index.Amsterdam | 73 |
| abstract_inverted_index.FcγRIIa, | 189 |
| abstract_inverted_index.Moreover, | 159 |
| abstract_inverted_index.different | 110, 118 |
| abstract_inverted_index.functions | 23 |
| abstract_inverted_index.infection | 1, 45, 69 |
| abstract_inverted_index.life-long | 7 |
| abstract_inverted_index.potential | 38 |
| abstract_inverted_index.receptors | 181 |
| abstract_inverted_index.requiring | 6 |
| abstract_inverted_index.response. | 171 |
| abstract_inverted_index.resulting | 125 |
| abstract_inverted_index.therefore | 10 |
| abstract_inverted_index.treatment | 8 |
| abstract_inverted_index.untreated | 67, 81 |
| abstract_inverted_index.(post-SC). | 99 |
| abstract_inverted_index.antibodies | 42, 115, 240 |
| abstract_inverted_index.associated | 57, 154, 164, 213, 220 |
| abstract_inverted_index.beneficial | 39 |
| abstract_inverted_index.contribute | 247 |
| abstract_inverted_index.correlated | 190 |
| abstract_inverted_index.especially | 255 |
| abstract_inverted_index.identified | 233 |
| abstract_inverted_index.particular | 187 |
| abstract_inverted_index.positively | 191 |
| abstract_inverted_index.properties | 35 |
| abstract_inverted_index.protective | 17 |
| abstract_inverted_index.underlying | 36 |
| abstract_inverted_index.alternative | 11 |
| abstract_inverted_index.association | 236 |
| abstract_inverted_index.development | 223 |
| abstract_inverted_index.individuals | 82 |
| abstract_inverted_index.information | 249 |
| abstract_inverted_index.progression | 162, 217 |
| abstract_inverted_index.strategies. | 262 |
| abstract_inverted_index.understood. | 48 |
| abstract_inverted_index.correlations | 199 |
| abstract_inverted_index.glycoprotein | 121 |
| abstract_inverted_index.progression, | 61 |
| abstract_inverted_index.progression. | 158, 195, 244 |
| abstract_inverted_index.Specifically, | 172 |
| abstract_inverted_index.approximately | 86 |
| abstract_inverted_index.therapeutics, | 12 |
| abstract_inverted_index.antibody-based | 258 |
| abstract_inverted_index.neutralization | 133, 205 |
| abstract_inverted_index.polyfunctional | 169, 239 |
| abstract_inverted_index.neutralization. | 229 |
| abstract_inverted_index.well-documented | 72 |
| abstract_inverted_index.Antibody-mediated | 21 |
| abstract_inverted_index.polyfunctionality | 65 |
| abstract_inverted_index.post-seroconversion | 98 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5040038561, https://openalex.org/A5001063223, https://openalex.org/A5017311188, https://openalex.org/A5048376079, https://openalex.org/A5046934232, https://openalex.org/A5055319253, https://openalex.org/A5067119119, https://openalex.org/A5033878006, https://openalex.org/A5076840670, https://openalex.org/A5101862520, https://openalex.org/A5054025307, https://openalex.org/A5066523822, https://openalex.org/A5017089987, https://openalex.org/A5087473572, https://openalex.org/A5016322668, https://openalex.org/A5069128652, https://openalex.org/A5065522081, https://openalex.org/A5089950087 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I123431417, https://openalex.org/I145902186, https://openalex.org/I165779595, https://openalex.org/I205783295, https://openalex.org/I4210099671, https://openalex.org/I4210105123, https://openalex.org/I4210151833, https://openalex.org/I56590836, https://openalex.org/I887064364 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.80149477 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |