Polymer Nanomedicines with pH-Triggered Pirarubicin Release: Revealing the Role of Carrier Hydrophilicity and Release Kinetics in Anticancer Performance Article Swipe
Sára Pytlíková
,
Benchun Jiang
,
Lucie Woldřichová
,
Kevin Kotalík
,
Ladislav Androvič
,
Shanghui Gao
,
Vladimír Šubr
,
Anna Rumlerová
,
Robert Pola
,
Natália Podhorská
,
Marcela Filipová
,
Mingjie Zhang
,
Michal Pechar
,
Jun Fang
,
Richard Laga
,
Tomáš Etrych
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.biomac.5c01344
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.biomac.5c01344
The therapeutic efficacy of antitumor nanomedicines is influenced by numerous factors, with the most critical being the selection of an appropriate biomaterial and the use of suitable stimulus-responsive linkers. The chosen biomaterial must be biocompatible and capable of binding the drug via a linker that facilitates selective release and activation of the therapeutic effect, specifically within tumor tissue. In this study, we designed, synthesized, and compared the physicochemical and biological properties of various polymer nanomedicines, each bearing pirarubicin conjugated to water-soluble and biocompatible methacrylamide-based copolymers through pH-sensitive hydrazone bonds. Our findings indicate that the hydrophobicity and length of the linker near the hydrazone bond are crucial factors influencing the treatment efficacy of the nanomedicines. Conjugates with aminohexanoyl linkers exhibited superior drug release and enhanced antitumor activity compared with those with shorter linkers. Overall, our study highlights that the rate of drug release, governed by the linker structure, plays a pivotal role in therapeutic efficacy, while the hydrophilicity of the polymer backbone has a lesser impact.
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- article
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- en
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- https://doi.org/10.1021/acs.biomac.5c01344
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- 28
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- https://openalex.org/W4414167659
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- OpenAlex ID
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https://openalex.org/W4414167659Canonical identifier for this work in OpenAlex
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https://doi.org/10.1021/acs.biomac.5c01344Digital Object Identifier
- Title
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Polymer Nanomedicines with pH-Triggered Pirarubicin Release: Revealing the Role of Carrier Hydrophilicity and Release Kinetics in Anticancer PerformanceWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-09-15Full publication date if available
- Authors
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Sára Pytlíková, Benchun Jiang, Lucie Woldřichová, Kevin Kotalík, Ladislav Androvič, Shanghui Gao, Vladimír Šubr, Anna Rumlerová, Robert Pola, Natália Podhorská, Marcela Filipová, Mingjie Zhang, Michal Pechar, Jun Fang, Richard Laga, Tomáš EtrychList of authors in order
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https://doi.org/10.1021/acs.biomac.5c01344Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acs.biomac.5c01344Direct OA link when available
- Cited by
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0Total citation count in OpenAlex
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28Number of works referenced by this work
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| abstract_inverted_index.numerous | 9 |
| abstract_inverted_index.release, | 141 |
| abstract_inverted_index.suitable | 26 |
| abstract_inverted_index.superior | 119 |
| abstract_inverted_index.antitumor | 4, 124 |
| abstract_inverted_index.designed, | 62 |
| abstract_inverted_index.efficacy, | 153 |
| abstract_inverted_index.exhibited | 118 |
| abstract_inverted_index.hydrazone | 87, 102 |
| abstract_inverted_index.selection | 17 |
| abstract_inverted_index.selective | 46 |
| abstract_inverted_index.treatment | 109 |
| abstract_inverted_index.Conjugates | 114 |
| abstract_inverted_index.activation | 49 |
| abstract_inverted_index.biological | 69 |
| abstract_inverted_index.conjugated | 78 |
| abstract_inverted_index.copolymers | 84 |
| abstract_inverted_index.highlights | 135 |
| abstract_inverted_index.influenced | 7 |
| abstract_inverted_index.properties | 70 |
| abstract_inverted_index.structure, | 146 |
| abstract_inverted_index.appropriate | 20 |
| abstract_inverted_index.biomaterial | 21, 31 |
| abstract_inverted_index.facilitates | 45 |
| abstract_inverted_index.influencing | 107 |
| abstract_inverted_index.pirarubicin | 77 |
| abstract_inverted_index.therapeutic | 1, 52, 152 |
| abstract_inverted_index.pH-sensitive | 86 |
| abstract_inverted_index.specifically | 54 |
| abstract_inverted_index.synthesized, | 63 |
| abstract_inverted_index.aminohexanoyl | 116 |
| abstract_inverted_index.biocompatible | 34, 82 |
| abstract_inverted_index.nanomedicines | 5 |
| abstract_inverted_index.water-soluble | 80 |
| abstract_inverted_index.hydrophilicity | 156 |
| abstract_inverted_index.hydrophobicity | 94 |
| abstract_inverted_index.nanomedicines, | 74 |
| abstract_inverted_index.nanomedicines. | 113 |
| abstract_inverted_index.physicochemical | 67 |
| abstract_inverted_index.stimulus-responsive | 27 |
| abstract_inverted_index.methacrylamide-based | 83 |
| cited_by_percentile_year | |
| countries_distinct_count | 3 |
| institutions_distinct_count | 16 |
| citation_normalized_percentile.value | 0.32761065 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |