Poor Sensitivity of Fecal Gluten Immunogenic Peptides and Serum Antibodies to Detect Duodenal Mucosal Damage in Celiac Disease Monitoring Article Swipe
Emilio J. Laserna‐Mendieta
,
María José Casanova
,
Ángel Arias
,
Laura Arias‐González
,
Pedro Majano
,
Luis Alberto Mate
,
C H Gordillo-Vélez
,
Mirella Jiménez
,
Teresa Angueira
,
Emilia Tébar-Romero
,
María Jesús Carrillo-Ramos
,
María Ángeles Tejero-Bustos
,
Javier P. Gisbert
,
Cecílio Santander
,
Alfredo J. Lucendo
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/nu13010098
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/nu13010098
A lifelong gluten-free diet (GFD) is the only current treatment for celiac disease (CD), but strict compliance is complicated. Duodenal biopsies are the “gold standard” method for diagnosing CD, but they are not generally recommended for disease monitoring. We evaluated the sensitivity and specificity of fecal gluten immunogenic peptides (GIPs) to detect duodenal lesions in CD patients on a GFD and compared them with serum anti-tissue transglutaminase (tTG) IgA antibodies. A prospective study was conducted at two tertiary centers in Spain on a consecutive series of adolescents and adults with CD who maintained a long-lasting GFD. Adherence to a GFD and health-related quality of life were scored with validated questionnaires. Mucosal damage graded according to the Marsh–Oberhüber classification (Marsh 1/2/3) was used as the reference standard. Of the 97 patients included, 27 presented duodenal mucosal damage and 70 had normal biopsies (Marsh 0). The sensitivity (33%) and specificity (81%) of GIPs were similar to those provided by the two assays used to measure anti-tTG antibodies. Scores in questionnaires showed no association with GIP, but an association between GIPs and patients’ self-reported gluten consumption was found (p = 0.003). GIP displayed low sensitivity but acceptable specificity for the detection of mucosal damage in CD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu13010098
- https://www.mdpi.com/2072-6643/13/1/98/pdf?version=1609900787
- OA Status
- gold
- Cited By
- 22
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3118151945
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3118151945Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu13010098Digital Object Identifier
- Title
-
Poor Sensitivity of Fecal Gluten Immunogenic Peptides and Serum Antibodies to Detect Duodenal Mucosal Damage in Celiac Disease MonitoringWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-30Full publication date if available
- Authors
-
Emilio J. Laserna‐Mendieta, María José Casanova, Ángel Arias, Laura Arias‐González, Pedro Majano, Luis Alberto Mate, C H Gordillo-Vélez, Mirella Jiménez, Teresa Angueira, Emilia Tébar-Romero, María Jesús Carrillo-Ramos, María Ángeles Tejero-Bustos, Javier P. Gisbert, Cecílio Santander, Alfredo J. LucendoList of authors in order
- Landing page
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https://doi.org/10.3390/nu13010098Publisher landing page
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-
https://www.mdpi.com/2072-6643/13/1/98/pdf?version=1609900787Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6643/13/1/98/pdf?version=1609900787Direct OA link when available
- Concepts
-
Medicine, Tissue transglutaminase, Gold standard (test), Gastroenterology, Antibody, Internal medicine, Gluten free, Gluten, Disease, Feces, Immunology, Pathology, Biology, Microbiology, Enzyme, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 4, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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