Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity Article Swipe
Naïm Bouazza
,
Michaëla Semeraro
,
Gabrielle Lui
,
Léo Froelicher Bournaud
,
Laure Choupeaux
,
Jean‐Marc Tréluyer
,
Sihem Benaboud
,
Joelle Terzic
,
Eric Hachulla
,
Philippe Rémy
,
Jérôme Harambat
,
Alexandre Karras
,
Caroline Rousset‐Rouvière
,
Anne Jolivot
,
Zahir Amoura
,
Éric Daugas
,
Aurélie Hummel
,
Rémi Salomon
,
Jean‐Christophe Lega
,
Stéphane Decramer
,
Alexandre Bélot
,
Delphine Gobert
,
N. Costedoat‐Chalumeau
,
Stanislas Faguer
,
Isabelle Melki
,
Noémie Jourde‐Chiche
,
Brigitte Bader‐Meunier
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/bcp.70103
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/bcp.70103
Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE) to forecast free prednisolone concentrations and its association with disease activity. Methods A total of 66 active SLE patients (adults and children) were included, and followed up prospectively (242 observations available). Plasma prednisolone concentrations were assessed using liquid chromatography‐mass spectrometry, and the data were analysed using Monolix software. The pharmacokinetic model was a one‐compartment open model with absorption lag time representing the delay for both absorption and metabolism from inactive (prednisone) to active form (prednisolone). This model predicted free concentrations, which were then used to calculate total concentrations based on established binding constants. Results Free prednisolone clearance (CLu/F) and volume of distribution (Vu/F) were scaled allometrically to body weight. The typical population estimates (95% confidence interval) were 54 (48–62) L/h/70 kg and 235 (203–274) L/70 kg, respectively. Additionally, the bioavailability parameter was found to decrease non‐linearly with the dose. Prednisolone cumulative exposure was not different between patients who responded at 3 months and those who did not. Conclusions Robust pharmacokinetic targets are not yet clearly defined regarding toxicity or efficacy and are warranted in order to make a valuable contribution to prednisolone therapeutic drug monitoring in the context of SLE.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/bcp.70103
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bcp.70103
- OA Status
- hybrid
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410693120
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410693120Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/bcp.70103Digital Object Identifier
- Title
-
Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-05-23Full publication date if available
- Authors
-
Naïm Bouazza, Michaëla Semeraro, Gabrielle Lui, Léo Froelicher Bournaud, Laure Choupeaux, Jean‐Marc Tréluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Rémy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouvière, Anne Jolivot, Zahir Amoura, Éric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Bélot, Delphine Gobert, N. Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐MeunierList of authors in order
- Landing page
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https://doi.org/10.1002/bcp.70103Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bcp.70103Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bcp.70103Direct OA link when available
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Prednisolone, Prednisone, Volume of distribution, Pharmacokinetics, Medicine, Population, Pharmacology, Internal medicine, Context (archaeology), Biology, Paleontology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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